• PharmaTutor
    7 October 2012

    EFFECT OF ALCOHOLIC EXTRACT OF ALOE VERA ON DRUG INDUCED MODEL OF COLITIS

    About Authors:
    A.D.Taranalli, Dilip Patoliya*, Sonal Chanchlani, Vishal Patel, Keyur Makadiya
    Department of Pharmacology and Pharmacokinetics,
    K.L.E. University’s College of Pharmacy, Belgaum.
    *Dilip_patoliya@yahoo.com

    ABSTRACT:
    Ulcerative colitis is a chronically recurrent inflammatory bowel disease of unknown origin in which oxidative stress has been implicated. The main aim of the present study was to evaluate possible protective effect of alcoholic extract of Aloe Vera against the drug induced model of colitis in rats. Induction of colitis by colonic administration of drugs(Acetic acid, Indomethacin and TNBS) cause severe microscopic inflammation of colon after 24 hrs of administration of one of any above  inducing agent, as assessed by the macroscopically. Microscopically colonic tissue showed ulceration, oedema and inflammatory cell infiltration. Biochemical estimation studies revealed decrease in serum levels of lactate Dehydrogenase (LDH) may be due to increase in Colonic concentration of tumor necrosis factor α (TNF- α) and neutrophill infiltration index. Oxidative stress was indicated by reduced glutathione concentration (GSH) as well as increase in levels of lipid peroxidase (LPO) and myeloperoxidase (MPO) activity in colonic tissue. Pretreatment with Aloe Vera extract at a dose of (400mg/kg/day, orally),10 days before induction of colitis increase level of serum LDH and GHS, while colonic concentration of LPO and MPO was increased. It also showed decrease in macroscopic score. The findings of the present study provide evidence that Aloe Vera extract may be beneficial in inflammatory bowel disease.

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  • 27 September 2012
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  • 27 September 2012
    Career for Clinical Studies Head/Clinical Pharmacologist in Manipal Acunova - alp consulting

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  • 25 September 2012
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  • 18 September 2012
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  • 30 August 2012
    A GENERAL OVERVIEW ON: STRESS AND ADAPTOGENS

    About Author:
    Sachin Kaushik
    P.G. Department of Pharmacology,
    B.L.D.E.A.’s college of Pharmacy,
    Bijapur- 586103, Karnataka,India.
    sachin_2004_kaushik@yahoo.com

    ABSTRACT
    In this general overview, we discussed about stress, types of stress, mechanism and its management. According to the report of WHO, approximately 450 million people suffer from mental or behavioral disorders like stress. This amounts to 12.3% of the global burden of disease and predicted to rise up to 15% by 2020. Therefore there is a need of an effective management to control stress and stress induced disorders.

  • 24 August 2012
    Pharmacist Trainee required in Hindustan Aeronautics Limited - 2 Posts | Freshers may apply - Govt Job

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  • 20 August 2012
    A STUDY ON ANTI-DIARRHOEAL ACTIVITY OF FRUIT EXTRACTS OF CARICA PAPAYA (CARICACEAE) LINN. IN RATS

    About Authors:
    S. Mahboob Ahmad, T.S Gouda
    V.L. College of pharmacy,
    Raichur, Karnataka-58410
    *syed.ahmad007@yahoo.com

    Abstract:
    The alcoholic and aqueous extracts of fruit of Carica papaya (Caricaceae)was investigated for anti-diarrhoealactivity in albino Wistar rats. The alcoholic and aqueous extracts was administered by the oral route at a concentration of 100, 200 and 400 mg/kg showed the significant dose dependent anti-diarrhoeal activity in Castor oil induced diarrhea and Magnesium sulphate induced diarrhea. Anti-diarrhoeal activity of the tested extracts was comparable with that of the standard drug Loperamide 3 mg/kg. The results lend support to the traditional use of C.  papaya in the treatment of diarrhoeal diseases.

  • 17 August 2012
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  • 17 August 2012
    Work as Medical Representatives / Marketing executives in Nano Life sciences, Bangalore

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    Post: Medical representatives/ Marketing Executives

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    Job Description:
    PROMOTE PRODUCTS THRO DOCTORS
    Qualification & Experience: +2 and above with good communication skills

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