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  • THE INDIVIDUAL EFFECT OF SURFACTANTS ON THE PENETRATION OF GLIMEPIRIDE TRANSDERMAL PATCHES USING DIBUTYLPTHALATE AS A PLASTICIZER

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    ABOUT AUTHORS
    P.Mounika,
    Dr Rinku mathappan, Sukriti Vishwas
    Gautham College of Pharmacy, Bangalore – 560032

    ABSTRACT

    Objective
    Glimepiride is an anti-diabetic drug with shorter half-life of 5 hrs. Glimepiride penetration into skin is difficulty. To study effects the penetration of glimepiride using different surfactants using dibutylpthalate.

    Methods
    Glimepiride transdermal Patches are prepared by using solvent casting method.  Eudragit E -100, Polysorbate 80, Polysorbate 60 are used as a penetration enhancers. Dibutylpthalate acts as a plasticizer for the penetration enhancement.

    Results
    The present study was to formulate and evaluate transdermal drug delivery system of Glimepiride. Results were evaluated for Thickness, Tensile strength, Folding endurance, and Drug content and In vitro penetration study was performed by using Franz diffusion cell. The drug content in transdermal patch F-1 shows 98,F-2 shows 93, F-3 shows 92.the drug permeation through matrix membrane shows good release with Eudragit E-100 copolymer and surfactant SLS. In comparison with three surfactants SLS gives good release for glimepiride with Eudragit E-100 matrix membrane.

    Conclusion
    From the results glimepiride with SLS anionic surfactant shows good penetration. Dibutylpthalate acts a plasticizer which improves the penetration of glimepiride.

  • ADMISSION OPEN FOR B.PHARM, D.PHARM AND M.PHARM AT LLOYD INSTITUTE

    Admission in Pharmacy college for B.Pharm, D.Pharm, M.Pharm

    Lloyd is a 15 years old Institute located in Greater Noida (Uttar Pradesh) and over the years it has gained prestige for its academic quality and the holistic learning experience gained by students on the campus. We offer the following Pharmacy programs:
    • B. Pharm
    • D. Pharm
    • M. Pharm. (Pharmaceutics)
    • M. Pharm. (Quality Assurance)

     

    The B.Pharm. program of Lloyd is accredited by the National Board of Accreditation (NBA), MHRD, Govt. of India which is responsible for “Promoting International Quality Standards for Technical Education in India”

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    Out of more than 600 pharmacy colleges in Uttar Pradesh, only 4 are NBA accredited and Lloyd is one of them.

    We are the only Institute in all over India to have collaboration with Delhi Pharmaceutical Sciences & Research University, (DPSRU), New Delhi.

    What sets up apart from other institutions-
    • Placements – we find jobs for pharmacy students from other colleges as well from all over India
    • Collaboration with Delhi Pharmaceutical Sciences & Research University, ( DPSRU)
    • NBA Accredited B.Pharm.
    • Industry linked program
    • Overall personality grooming
    • Foreign language training

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    For further details call: 9821394572, 9821394573, 9990571481, 9899578978

    Lloyd Institute of Management & Technology
    Plot No. 11, Knowledge Park-2
    Greater Noida-201306
    http://www.lloydpharmacy.edu.in
    lloyd.pharmacy@gmail.com

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