Guntur

22 March 2013

DEVELOPMENT AND VALIDATION OF A REVERSED-PHASE HPLC METHOD FOR ASSAY OF AZITHROMYCIN IN POWDER FOR ORAL SUSPENSION

About Author:
Swapna.G*
Department of pharmaceutical Pharmaceutical & Quality Assurance,
Nirmala College of Pharmacy, Mangalagiri, Atmakuru, Guntur -522 203.
*swapna.goday.gs@gmail.com

Abstract
A simple, precise and accurate reversed phase liquid chromatographic method has been developed for the assay of azithromycin in powder for oral suspension. The chromatographic separation was achieved on a Asahipak ODP 40 E(250 mm × 4.6 mm, 5 μm) analytical column. A mixture of methanol–ammonium dihydrogen phosphate (0.05M) (30:70, v/v) (pH 9.0) was used as the mobile phase, at a flow rate of 1.5 mLmin^-1 and detector wavelength at 210 nm. The retention time of azithromycin was found to be at 8.0 min. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, robustness and stability indicating assay. The linear dynamic range is from 382–1208 μgmL^-1 for azithromycin. The percentage recovery obtained for azithromycin is 101.0%. The developed method can be used for pharmaceutical dosage form and in process testing.
24 January 2013

ENHANCEMENT OF DISSOLUTION RATE OF CEFIXIME TRIHYDRATE BY USING VARIOUS SOLID DISPERSION TECHNIQUES

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.
14 January 2013

Andhra Pradesh State AIDS Control Society invites Staff Nurse, Pharmacist, HIV Research Fellow (Non clinical) | 12 Posts

Applications are invited from qualified and suitable candidates to work at ART Centre in various districts of A.P. Interested Candidates can send their biodata duly specify the Name and Post applied, along with copies of their qualification and experience certificates to the address of Concerned Medical Superintendent, of the respective Hospitals (RIMS/District Hospital /Area Hospital/Government General Hospital.)
20 September 2012

CHRONOPHARMACOKINETICS: THE CIRCADIAN RHYTHM OF DRUGS AND ITS IMPLICATIONS

About Authors:
N Allamneni*, CH Ajay Babu, AVS Madhulatha, C Anusha, P Sowjanya, BV Komali, M Kalyani, Syed M
*Department of Pharmaceutical Technology,
Narasaraopeta Institute of Pharmaceutical Sciences,
Narasaraopeta, Guntur, India.
*yaswanthallamneni@gmail.com

ABSTRACT
Chronopharmacokinetics involves the study of temporal changes in drug absorption, distribution, metabolism and excretion with respect to time of administration. Drug Absorption, distribution, metabolism and elimination are influenced by many different physiological functions of the body, which may vary, with time of day. Thus, the pharmacokinetic parameters characterizing these different steps, conventionally considered to be constant in time, depend on the moment of drug administration. Chronokinetic studies have been reported for many drugs in an attempt to explain chronopharmacodynamic phenomena and demonstrate that the time of administration is a possible factor of variation in the kinetics of a drug. However, the time of day has to be regarded as an additional variable influencing the kinetics of a drug since many drugs are affected by time of administration and the activity or rest period of the human or animal.
18 September 2012

NEWER ANTILEPTICS- NECESSITY OF LIMITED DOSAGE

About Authors:
A.Prameela Rani¹, V.Hema^2*
¹University college of pharmaceutical sciences,
Acharya nagarjuna University, Guntur.
^2*KVSR Siddhartha college of pharmaceutical sciences, Vijayawada.
*hemav_pharma@rediffmail.com

ABSTRACT:
Epilepsy is a disorder of CNS characterized by paroxysmal cerebral dysrhytmia, manifesting as brief episodes of loss or disturbance of consciousness with or without characteristic body movements, sensory or psychiatric phenomenon.
Some drugs such as felbamate, oxcarbazepine, gabapentin, zonisamide, topiramate and pregabalin before consumption their dose and dosage should be checked. All the drugs should be adjusted surely for their dosage especially in renal impairment patients. The present review is on serious effects due to overdosage of various newer anticonvulsants.
3 May 2012

QUALITY OF WATER FOR PHARMACEUTICAL USE: AN OVERVIEW

About Authors:
YASWANTH ALLAMNENI^1*, NAVYA ALLAMNENI², P DAYANANDA CHARY¹, G VIJAY KUMAR³, ARUN KUMAR KALEKAR¹, PAVAN KUMAR POTTURI¹
¹Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh – 509228.
²Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur, India.
³Principal, A.K.R.G college of Pharmacy, Nallagerla, West Godavari, Andhra Pradesh.
*yaswanthallamneni@gmail.com

ABSTRACT
Water is widely used as a raw material, ingredient, and solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, compendial articles, and analytical reagents. This review discusses, primarily from a microbiological aspect, the review and evaluation of high purity water systems that are used for the manufacture of drug products and drug substances. It also includes a review of the design of the various types of systems and some of the problems that have been associated with these systems. As with other guides, it is not all-inclusive, but provides background and guidance for the review and evaluation of high purity water systems. The main objective of this review was to provide guidance to the industry on the pharmaceutical use of different grades of water in the manufacture of active pharmaceutical ingredients and medicinal products for human and veterinary use. This guidance is not intended to cover situations where, for example, medicinal products are prepared extemporaneously or where preparations are reconstituted or diluted with water prior to use by pharmacist (eg. Oral antibiotic mixtures) or in the case of veterinary products by the user (eg. Sheep dips).
27 January 2012

Community survey on Rural women health

About Authors:
M.sandhya sree*, Sowmya**
*Assistant Professor ,
Department of pharmacology,
BA&KR pharmacy college,
JNTUK, Andhra Pradesh.
**MBBS,GMC,
Guntur, Andhra Pradesh.

Abstract:
The study was conducted in two villages of Guntur district (Andra Pradesh) to determine the nature and extent of health problems of rural women. The data were collected from one hundred randomly selected rural ladies by interviewing them with the help of an interview schedule developed for the purpose.
The identified health problems were classified. The findings of the study indicated the prevalence of a number of health problems among rural women and a need was felt for their education on health aspects. A sizeable number of them were found to have suffered from bronchitis, coryza, indigestion, constipation, diarrhea , conjunctivitis, dandruff, tartar deposits on teeth, skin diseases, gynecological diseases and some other diseases like rheumatism, arthritis, etc.
The existence of a government hospital in village had no association of significant level with the health problems of rural women. Majority of the respondents perceived the treatment given in government hospital to be not effective and several other constraints in availing of the treatment facilities.
26 December 2011

Concepts and philosophy of ICH

About Authors:
Sahithya Bitragunta, Ponnuru Venkata Suresh, Nadendla RamaRao
Chalapathi institute of pharmaceutical sciences,
Lam,Guntur,
India.

Abstract:
In 1960’s, different countries used to have different set of guidelines and laws for the registration and marketing of pharmaceuticals. But tragedies like Thalidomide disaster made harmonization of all technical requirements which are required for the registration of pharmaceuticals for the human use. Thus ICH has been launched in 1990 by drug regulatory authorities and pharmaceutical industrial members of Europe, Japan and US with an objective of providing guidelines to ensure the registration and marketing of safe, effective and high quality medicines.

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28 October 2011

QUALITATIVE AND QUANTITATIVE ANALYSIS OF DNA BY SPECTROPHOTOMETRY

ABOUT AUTHORS:
Amar Nagesh Kumar¹, Reena jose², Praswetha Reddy³
1 Lecturer, Department of Biochemistry, SSR Medical College, Mauritius
2 M. Sc Biotechnology, Yogi Vemana University
3 M. Sc Biochemistry, Mahatma Gandhi P.G College, Guntur

OBJECTIVE:To estimate the given samples of DNA qualitatively and quantitatively and know its purity and concentration.

BACKGROUND
Quantification of nucleic acids is commonly used in molecular Biology to determine the concentration of DNA and RNA present in the mixture As subsequent reaction or protocols using the nucleic acids sample of a required particular amount of optical performance. Both DNA and RNA exhibit strong absorbance of UV due to the presence of conjugated double bonds of the constant purine and pyramidine bases and these have characteristics of OD (optical density)of absorbance maximum at 260nm which is linearly related with the concentration of the DNA in the solution up to the OD value of 2 . The spectroscopic method is used to check the purity of DNA. Proteins are the major contaminants in the nucleic acid extracts and these have the maximum absorbance at 280nm. Value less than 1.8 signifies the presence of proteins as impurities.
31 August 2011

Requirement of Pharmacists in Razi Clinics - Fresher

The Razi Advantage comes from linking the entrepreneurial energy of their doctors to a brand that patients can trust. With the Razi Clinics brand, they offer a patient-centred approach to health care with a guarantee of affordability.

Post: Pharmacits