Guntur

Job as Asst. Professors at K C Reddy Institute of Pharmaceutical Sciences

K.C.REDDY college was established in the year 2007, and sponsored by NRI'S K.C.REDDY COLLEGE, the parent educational organisation of is a Balaji Educational Society, established in the year 2007 to contribute and serve the educational field by establishing schools, colleges and technological institutions to impart quality oriented, merit-targeted education. K.C.REDDY COLLEGE was established in August 2007 with the approval of AICTE, New Delhi and is affiliated to ANU,Guntur Andhra Pradesh

Post: Asst. Professors-01

EVLUATION OF EFFECTS OF COMMIPHORA WIGHTII IN DEHYDROEPIANDROSTERONE (DHEA) INDUCED POLYCYSTIC OVARY SYNDROME (PCOS) IN RATS

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ABOUT AUTHORS:
Kavitha.A*, Narendra Babu.A, Sathish Kumar M, Veena Kiran.S

Department of pharmacology
Chalapathi institute of pharmaceutical sciences,
Lam, Guntur-522034, Andhra Pradesh
andugulakavitha@gmail.com

ABSTRACT
Background:

Hyperandrogenism and insulin resistance are the main manifestations of polycystic ovary syndrome (PCOS), which appears to be caused by exposure to androgenized models have developed and investigated to study the etiology of polycystic ovary syndrome.
Objective:

To evaluate the modulatory effects of Commiphora wightii (C.wightii) resins in response to hyperandrogenism in polycystic ovary syndrome.
Method:

The animals were divided 18 adult (5-6 months old) wistar rats in to 4 groups the PCOS model was induced by daily administration of dehydroepiandrosterone (DHEA) 6mg/Kg in sesame oil p.o., up to 15 days and the rescue groups were take daily with metformin and C.wightii resin ethanolic extract 100mg/ kg in addition to DHEA. Serum glucose levels measured and steroid hormone levels were measured by fully automated bidirectionally interfaced chemi luminescent immunoassay. Samples were stained with hematoxylin and eosin for histological morphology.
Results:

The obtained results related to DHEA induced PCOS a significant (P<0.05) increase in hormone profile (estradiol, testosterone, progesterone, luteinizing hormone, follicle stimulated hormone) in PCOS rats in adult rats than the rescue groups. Furthermore glucose levels significantly (<0.05) elevated in PCOS rats compared with the other groups. The test treated ovaries had lower number of follicles compared to DHEA control group and similar to that of the control group than the standard.
Conclusion:

Commiphora wightii
resin has a potential role in reducing DHEA induced PCOS by reducing the morphological abnormalities of the ovarian follicles and normal hormone levels in adult rats.

A.M. Reddy Memorial College of Pharmacy requires Faculty position | Specialization of Pharmaceutics, Analysis, Pharmaceutical Chemistry, Pharmacology, Pharmacognosy & Pharm.D

A.M. Reddy Memorial College of Pharmacy was founded in 2003 by NRIs Sri. Atluri Srinivasa Reddy and Mrs. Atluri Santhi under Atluri Mastan Reddy Educational Society, which is situated at Petlurivaripalem, Narasaraopet. The college is housed independently pollution free, picturesque lush green environment with a well-equipped with the state of art facilities. It is approved by AICTE(All India Council for Technical Education), New Delhi and PCI(Pharmacy Council of India), New Delhi. The college has been ever-driven by the greater aspirations to provide the finest quality of Pharmacy Education, richly implanted in its brilliant infrastructure and ultra modern resources to ultimately mould every student with academic excellence.

Post: Professors/ Associate Professors/ Assistant Professors

Need of B.Pharm as Executive- Training & Development (3 posts) from Andhra Pradesh in Apollo Pharmacy

Apollo Pharmacy is a leading retail chain of pharmacy and is a unit of - Apollo Hospitals Enterprise Ltd. - Asia's largest healthcare group.
Our growing Retail Pharmacy network touches lives across the length and breadth of India and we serve 150000+ customers a day. With over 30 years of retailing experience, customer-focused service and brand value our network spans out to 1550+ retail pharmacies through which we have been serving our customers for their healthcare needs 24x7.

Post: Executive- Training & Development(Technical Trainer), 3 Nos

FORMULATION DEVELOPMENT AND IN VITRO CHARACTERIZATION OF SUSTAINED RELEASE PELLETS OF VENLAFAXINE HCl

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About Author:
Anitha Nidadavolu
Department of Industrial Pharmacy
Chalapathi Institute of Pharmceutical Sciences
Chalapathi Nagar, Lam, Guntur-522034,
Andhra Pradesh, India.
anitha058@gmail.com

Abstract:
In the present study, an attempt was made to develop and characterize once dailysustained release pellets of highly water soluble drug Venlafaxine Hydrochloride, which is an antidepressant of serotonin-nor epinephrine reuptake inhibitor (SNRI). Compatibility studies by FTIR spectroscopy observed Venlafaxine HCl was compatible with all the excipients used. These pellets were prepared in three stages. In drug loading stage (powder layering technique with pan coater), drug was loaded on non-pareil sugar spheres by using Mannitol, Microcrystalline powder (MCCP) as diluents and PVP K30 as binder. The concentration of Venlafaxine HCl was kept constant. Four preliminary batches of drug loaded pellets prepared by varying concentrations of disintegrant Crospovidone INF-10 (D1- D4) i.e. 1.5%, 3%, 4.5%, 6%. Optimized formulation was selected based on percentage yield, drug content (assay) and found D3- 4.5% as best. In barrier coating stage(wurster process with fluidized bed coater) drug loaded pellets of D3 were coated by different concentrations of film former HPMC E3 (B1- B3) i.e.4%, 6%, 8%. Among them, B2- 6% found as best. In SR coating stage (wurster process with fluidized bed coater) barrier pellets of B2 were coated by varying concentrations of release rate retarding polymer Ethyl cellulose EC 7 cps (S1- S4) i.e. 2%, 5%, 6%, 8%. These EC (S1- S4) formulations were characterized fordrug content (assay), particle size distribution, friability,flow properties, surface morphology (SEM) and dissolution profile.In vitro dissolution studies were carried out by USP dissolution apparatus Type-II and compared with innovator Effexor XR®. Among all formulations S4(8%) was best, followed first order kinetics and found to release the drug over a sustained period of time up to 24 hrs. The release exponent (n values) for all found in the range of n > 1, indicated that the drug transport mechanism by super case-II transport. The optimized S4 formulation was found as pharmaceutically equivalent to innovatordue to similarity (f2 =77.77) in drug release profile. As per ICH guidelines, accelerated stability studies conducted and there was no significant difference in physicochemical parameters (p < 0.05), indicated that the optimized S4 formulation was stable.

ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY

About Authors:
Jasinth. Danda*, Dr. P.Venkateswara Rao, P.Rama Bharathi, B.Madhavi, T.Swathi, Satya Lakshmi. Balla
A.M Reddy Memorial College of Pharmacy,
Department of Pharmaceutical Analysis
Narasaraopet, ANU University, Guntur.
Jasinthdanda18@gmail.com

1. Introduction
Chromatography is relatively a new technique which was first invented by M.Tsweet, a botanist in 1906 in Warsaw. He was successful in doing the separation of chlorophyll, xanthophylls and several other coloured substances by percolating vegetable extracts through a calcium carbonate. The calcium carbonate acts as absorbent and the different substances got adsorbed to different extents and this gives rise to coloured bands at different positions on the column. Tsweet termed this coloured bands as chromatogram and the method as chromatography after the Greek words chroma and graphos  meaning colour and writing respectively.

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND EPERISONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS

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About Authors:
Venkata Anil Kumar Sistla*, Dr.P.Venkateshwara Rao, P.Rajavel
Department of Pharmaceutical Analysis
A.M.Reddy Memorial College of Pharmacy,
Narasaraopeta - 522601,
Guntur Dt, India.
*anilkumar5831@gmail.com

Abstract
A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Paracetamol and Eperisone Hydrochloride in pharmaceutical Tablet dosage form. The mobile phase consisted of 60:40 % (v/v) of Methanol & 0.1% v/v orthophosphoric acid operated on isocratic mode. The flow rate is 1.0 ml/min. Chromatographic separation of Paracetamol and Eperisone Hydrochloride was performed on PHENOMENEX C18 column (150 X 4.6 cm, ODS, 5µm). The wavelength of detection is 270 nm. The injection volume is 20µL. The retention time of Paracetamol and Eperisone Hydrochloride are 2.21 ± 0.10 minutes and 2.74 ± 0.10 respectively. The run time of analysis is 6 minutes. The developed method was validated for parameters such as accuracy, precision, linearity, limit of detection, limit of quantitation. The influence of acid, alkaline, oxidative Stress and photolytic stress conditions on both the drugs was studied. Results indicated partial degradation in alkaline medium for Paracetamol and Eperisone Hydrochloride. The proposed method has been successfully used for the estimation in tablet dosage forms.

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