Bathinda

INDOLE BASED ALKALOID IN CANCER: AN OVERVIEW

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About Authors:
Ramit Singla1, Arvind Negi1*, Virendra Singh2
1Centre for Chemical and pharmaceutical sciences, Central university of Punjab, Bathinda, India
2Department of Chemistry, National institute of technology, Jalandhar, India
*arvindnegi2301@gmail.com

Abstract:
Indole alkaloids are well characterized for diverse activities. Meanwhile, the present scenarioof disease depicting a different story, urge a call for novel scaffolds and pharmacophores. In recent years, indole based alkaloids gain significant importance in cancer chemotherapy and used as an adjuvant especiallyin case of Vinca alkaloids. These reports encourage the researchers for new finding related to indole based alkaloids to retrieve better scaffold for designing and synthesis of anticancer agents. However we tried to compile the literature which cover the recent reports and updates of indole based alkaloids targeting incancer. Moreover this review paperbrings new dimension and interface between the indole based alkaloids and their valuable commitment towards cancer targeting.

Walk in for M.Pharm or M.Sc in DST sponsored project as Junior Research Fellow in Central University of Punjab

The Central University of Punjab, Bathinda (Punjab) has been established through the Central Universities Act 2009 which received the assent of the President of India on 20th March 2009. Its territorial jurisdiction extends to the whole State of Punjab. This newly set up Central University of Punjab (CUP) at Bathinda is poised to write new alphabet on the academic horizon of India. This University is one of the important links in the recently set up chain of Central Universities created in the educationally backward areas of India. Going to be an upwardly mobile organization, it is destined to emerge as a quality provider of teaching and research, knowledge and skills, products and services, attitudes and ethics. It is gearing up to provide proper institutional leadership to the emerging demands of access, equity, relevance and quality in the mainstream University system. It has already flexed its muscles and initiated its first academic session.

Applications are invited for the post of Junior Research Fellow for DST sponsored project:

Post: Junior Research Fellow - 1 Post (Centre for Chemical and Pharmaceutical Sciences)

SUCCESS STORIES OF ENOLATE FORM OF DRUGS

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About Authors:
Arvind Negi1*, Balraj Singh Gill2
1Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
2Centre for Biosciences, Central University of Punjab, Bathinda-151001
*arvindnegi2301@gmail.com

Abstract
Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enol form ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!

ANAPHYLACTIC SHOCK: SHOCKING ERROR OF IMMUNE SYSTEM!

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About Author:
Arvind Negi
Centre for Chemical and Pharmaceutical Sciences
Central University of Punjab, Bathinda-151001
arvindnegi2301@gmail.com

Abstract
Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!

Area Sales Manager require in Synergy Diagnostics | All India Level

Synergy Diagnostics pvt Ltd, a Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.

Work as Area sales Executive/Medical representative in Synergy Diagnostics - Freshers may apply

Synergy Diagnostics pvt Ltd, a Leading Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.

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