Gujarat

ABOUT AUTHORS:
Dipal Patel^*1, Dr. Kamal Singh Rathore¹, Dr. O.P.Mahatma¹, Twinkal Patel^2
1B.N. Institute of Pharmaceutical Sciences, Udaipur (Rajasthan), 313001
²Shree Sarvajanik College of Pharmacy, Mahesana (Gujarat).
*dipalpatel786@gmail.com

ABSTRACT:
Asthma is a respiratory disease that affects both adults and children and asthma is today one of the most common chronic childhood ailments. There is no scientifically proven cure for asthma but it can be controlled and regulated. Natural treatments for asthma are meant to complement, or as an addition, to your existing medication but never as a replacement. Before using an herbal asthma remedy keep in mind that medicinal herbs can be as powerful as pharmaceutical drugs and should be treated as such so it is important to seek the support of your health care provider as some natural herbs for asthma treatment may conflict with pharmaceuticals commonly prescribed for asthma.

ABOUT AUTHORS:
Ketan M. Parmar*, Ritesh N. Sharma
S.K.Patel College of Pharmaceutical Education & research,
Department of Pharmaceutical chemistry, GANPAT UNIVERSITY.
*brave_student_90@yahoo.com

ABSTRACT
With the development of technologies to look at the expression levels of hundreds of miRNAs at a time and the clear role of miRNAs in cancers, groups began looking at miRNAs profiles of different cancers,especially the circulating miRNAs. We intended to make sure whether circulating miRNAs could be a promising biomarker of human cancers. Method: We comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Nov 2009 for the following terms: (“miRNA” or “microRNA”) and (“tumor” or “carcinoma”) and (“plasma” or “serum” or “circulating”). Detailed information was extracted from studies that met the inclusion criteria: blood-based miRNAs in human cancers and studies published in the English literature. Results: The current review show that different researches use different measurement methods which might impact the results;Cancers treatment might have an effect on circulating miRNAs; some miRNAs are multi-faceted RNA; small sample size might produce selection bias. Furthermore, because of the lack of randomized controlled trials and the heterogeneous nature of the available data, no attempt was made to perform quantitativemeta-analyses.
In this review, based on those researches, circulating miRNAs are promising and difficulties for their future application for diagnosing human cancers.

ABOUT AUTHORS:
Rima M. Bankar*, Dipti B. Patel
Department of Pharmaceutical Analysis,
Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University,
Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
*rima.banker@yahoo.com

ABSTRACT
A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for  simultaneous determination of Montelukast Sodium and Desloratadine. The method showed adequate separation for Montelukast Sodium and Desloratadine  and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Methanol-Water (15:80:5, v/v) as a mobile phase at a flow rate of 1.0 ml/min and wavelength of 283 nm. The calibration curves were linear over the concentration ranges of 5-50 μg/ml for Montelukast Sodium and Desloratadine. The limit of detection (LOD) and limit of quantification (LOQ) for Montelukast Sodium were 0.33 and 1.01 μg/ml while for Desloratadine were 0.10 and 0.31 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Montelukast Sodium and Desloratadine in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

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