Gujarat

Simultaneous Spectrophotometric Determination of Cefixime and Moxifloxacin in Bulk Drug and Drug Formulation by Absorption Ratio Method

About Authors:
Shah Chirag K.*, Umalkar Deepak, Dr. Rajesh KS.
Parul Institute of Pharmacy, Gujarat University,
Waghodia-391760, Dist. Vadodara,
Gujarat, India.
*cks2484@gmail.com

Abstract:
The present manuscript described the simple, rapid, accurate, sensitive, precise and economical Q- absorption ratio method for simultaneous determination of Cefixime and Moxifloxacin in combined tablet dosage form. Absorption ratio method uses the ratio of absorbances at selected wavelengths, one which is isoabsorptive point and other being the λmax of the one of the components. Cefixime and Moxifloxacin shows isoabsorptive point at 275nm in 0.1N HCl. The second wavelength used is 295nm, which is λmax of Moxifloxacin. The concentrations of the drugs were determined by using ratio of absorances at isoabsorptive point and at λmax of Moxifloxacin. The method successfully applied to the Pharmaceutical formulation because no interference from the tablet formulation excipients was found. The results of analysis have been validated statistically and by recovery studies.

To Evaluate Anti-inflammatory Activity of leaves of Lawsonia inermis in rats

About Authors:
ATUL KABARA*, RUCHI THAKKAR, NITIN PATEL
Department of Pharmacology
G.H.B Pharmacy college,
Aniyad,Gujarat
*atul.kbr@gmail.com

ABSTRACT:
Lawsonia inermiscommonly known as Henna is a perineal herbaceous plant belonging to family Lauraceae. Traditionally it has been used to treat skin disease, dysentery, bronchitis, anemia and inflammation . The aim of present study was to investigate the anti-inflammatory activity of aqueous extract of Lawsonia leaves in rats. Aqueous extract was administered at a dose of 250mg/kg and 500mg/kg.

CORTICOSTEROIDS USE IN PREGNANCY

About Authors:
Patel Brilina M*, Yadav Nisha D, Maheta Payal, Arora Bhoomi
Institute of clinical research India,
Ahmedabad,
Gujarat, India
*patelbrilina@gmail.com

Abstract:
Corticosteroids, often referred to as steroid medications, contain man-made versions of the hormone cortisol. Corticosteroids are mainly used to relieve inflammation. Inflammation occurs when the immune system causes part of the body to become swollen, red and filled with fluid in response to an infection. The immune system is the body’s natural defence against infection and illness. Steroids form an important component in pregnancy to reduce the inflammation and are used since very long time for different conditions in different forms. Though very few molecules are used since very long time. Now increase knowledge in uses of corticosteroids in pregnant women who suffer from asthma, skin diseases, rheumatoid arthritis etc.

Filling up of posts of Technical/ Scientific services of Food Safety and Standards Authority of India - 32 posts

The Food Safety and Standards Authority of India (FSSAI) is an autonomous statutory Authority set up under the Food Safety and Standards Act, 2006 for laying down science based standards for articles of food and to regulate their manufacture, storage, distribution, sale and import to ensure availability of safe and wholesome food for human consumption.

SUPERPOROUS HYDROGEL: A SUPREME APPROACH FOR GASTRIC RETENTION

About Authors:
Jigar Modi*1, Dr. Jayvadan Patel1, Dr. Hitesh chavda2

1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
2Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

PHARMACODYNAMIC INTERACTION OF FENUGREEK LEAVES EXTRACT WITH FLUVASTATIN IN DIABETES INDUCED VASCULAR DYSFUNCTION

About Authors:
ATUL KABRA* , PREMAL KAPADIA
Department of Pharmacology,
G.H.B Pharmacy college,
Aniyad, Gujarat

* atul.kbr@gmail.com

ABSTRACT:
The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

Sorbead India invites B.Pharm, B.Sc fresher or experience to work as Business Development Manager / Executive, Product Managers - 8 posts

Sorbead India is an ISO 9001 accredited fast growing organization engaged in manufacturing & exports of "Adsorbents & Desiccants" The company is in explosive growth phase and is looking for personnel for its various divisions. We are looking for dynamic & result oriented achievers who have abilities to take challenges. Following are recent openings for our Vadodara Office:

Require M.Sc./M.Pharm for Stem Cell Research at Department of Cell and Molecular Biology, B. V. Patel PERD Centre

In October 1990 the B. V. Patel Education Trust in conjuncture with the Indian Pharmaceutical Association established B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, in the memory of late Mr. B. V. Patel, the first Drug Controller of Gujarat.

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