Anup Megotia*, Meenu Nagpal, Upendra K Jain, Varun
Dept. of Pharmaceutics, Chandigarh College of Pharmacy,
While rapidly disintegrating tablets do not necessarily ensure fast bioavailability, slowly disintegrating tablets almost always assure slow bioavailability. Drug release from a solid dosage form can be enhanced by addition of suitable disintegrants. Super disintegrants are effective in lower concentrations when compared to conventional disintegrants offer significant improvements over them. The disintegrants may employ any of the following mode for disintegration or a combination of them: by capillary action or wicking, by swelling or due to deformation. The disintegrant activity may be affected by several factors like molecular structure, compression force, excipient activity etc. The major superdisintegrants used today include sodium starch glycolate, croscarmellose sodium, crospovidone and polacrilin potassium.