Rajasthan

24 December 2012

ETHOSOMES: A NOVEL VESICULAR CARRIER FOR TRANSDERMAL DRUG DELIVERY

About Authors:
Patel Chirag J^*1, Prof. Satyanand Tyagi², Patel Pinkesh¹, Umesh Kumar¹, Patel Jaimin¹, Chaudhari Bharat¹
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
*Mr. Chirag Patel has published various Books, Research and Review articles. His academic works include 35 Publications (2 books was published in Lambert Academic Publishing, Germany & 8 Research Articles and 25 Review Articles was published in standard and reputed National and International Pharmacy journals)
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
*chirag.bangalore@gmail.com, +91-8000501871

ABSTRACT:
Transdermal drug delivery system is a type of convenient drug delivery system where drug goes to the systemic circulation through the protective barrier i.e. Skin. Skin acts as a major target as well as a principal barrier for topical / transdermal drug delivery. Vesicular system is one of the most controversial methods for transdermal delivery of active substances in that ethosome are the ethanolic phospholipids vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. The increased permeation of ethosomes is probably due to its ethanolic content. Ethanol increases the cell membrane lipid fluidity which results in increased skin penetrability of the ethosomes. These ethosomes permeates inside the skin and fuse with cell membrane lipids and release the drug. Hot and cold methods are used for formulation of ethosomes. Characterizations of ethosomesinclude Particle size, Zeta potential, Differential Scanning Calorimertry (DSC),Entrapment efficiency, Surface tension activity measurement, Vesicle stabilityand Penetration Studiesetc.
21 December 2012

ANTIANXIETY ACTIVITY OF EMBELIN ISOLATED FROM EMBELIA RIBES

About Authors:
Mukesh Bansal¹*, Indrajeet Singhvi², Santosh Gupta²
¹Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, U.P., India.
²Pacific College of Pharmacy, Pacific University, Udaipur, Rajasthan, India.
*bansalpharma1987@gmail.com

Abstract:
Object:
To investigate the effect of embelin on anxiety was studied by using standard test such as Elevated zero-maze test and Novelty induced suppressed feeding latency test in a dose dependent manner.
Material & methods:
This portion include extraction and isolation of embelin, animals were obtained from the animal house IMS, BHU, Varanasi, India, and methods for anxiety were Elevated zero-maze test and Novelty induced suppressed feeding latency test.
Result & conclusion:
The anxiolytic activity was found at 20mg/kg. The observed anxiolytic effect of this compound seems to be regulated through monoaminergic system in the brain and the activity was comparable to diazepam.
21 December 2012

MOUTH DISSOLVING TABLET: A OVERVIEW

About Authors:
Ashish Kumar Garg*, M.M. Gupta
Department of Pharmaceutics, Jaipur College of Pharmacy,
Jaipur, Rajasthan
*ashish1pharma@gmail.com

Abstract
Conventional dosage forms like tablets and capsules are now days facing the problems like dysphagia, resulting in the high incidence of non compliance and making the therapy ineffective. To obviate the problems associated with conventional dosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration and serves as the first choice of dosage form for paediatrics, geriatrics and traveling patients. The MDTs were developed with an aim of having sufficient hardness, integrity and faster disintegration without water. Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within <60 seconds.
20 December 2012

NOVEL APPROACH OF BILAYERED TABLETS: AN OVERVIEW

About Authors:
Patel Pinkesh^*1, Patel Chirag J¹, Prof. Satyanand Tyagi², Umesh Kumar¹, Patel Jaimin¹, Chaudhari Bharat¹
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
*pinkesh.patan@yahoo.com, +91-8866436904

ABSTRACT:
In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry. Pharmacokinetic profile relies on the fact that the fast release layer provide the loading dose of drug and the sustained release of drug maintain the drug concentration within therapeutic window for longer period of time. Bilayer tablets offer definite advantages over conventional release formulation of the same drug. Now a day, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction.
17 December 2012

MICROBIAL ASSAY OF ANTIBIOTICS

About Authors:
Nilesh Sovasia*, Arshad Hala
Seth G.L.Bihani S.D.College Of Technical Education,
Institute Of Pharmaceutical Science & Drug Research,
Sri Ganganagar, Rajasthan, India
*nilesh.sovasia@yahoo.com

ABSTRACT
The microbiological assay of an antibiotic is based upon a comparison of the inhibition of growth of micro-organisms by measured concentrations of the antibiotics under examination with that produced by known concentrations of a standard preparation of the antibiotic having a known activity.

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16 December 2012

SunRise University - Alwar invites Ph.D Programme

SunRise University is a Regular University Established by Government of Rajasthan vide SunRise University Act, 2011 and Recognized by University Grants Commission (UGC) u/s 2(f) of UGC Act, 1956. University is started with a vision to meet the dynamic needs of competitive world around us through a valued systematic functioning and turn out professionals of calibre and competence, which would bring about a qualitative change to nation through their contribution.
14 December 2012

PERSONALITY DISORDERS

About Authors:
¹Sahu Deepak*
¹Ass. Professor, Geetanjali Institute of Pharmacy,
Dabok, Udaipur [Rajasthan] – 313022
*deepak.sahu.bhl@gmail.com

DEFINITION:
Personality disorders are a group of mental disturbances & it is a psychiatric condition characterized by experience and behavior patterns that cause serious problems with respect to any two of the following: thinking, mood, personal relations, and the control of impulses.¹
Personality disorders are defined by the American Psychiatric Association as "an enduring pattern of inner experience and behavior that deviates markedly from the expectations of the culture of the individual who exhibits it".^1,2
14 December 2012

PPARG AGONIST: ROLE OF DIABETES IN TYPE- 2

About Author:
swati khandelwal
Maharishi arvind college of pharmacy,
rajasthan university of health science, jaipur
imswatikhandelwal@gmail.com

1. DIABETES
1.1 INTRODUCTION-
Diabetes is a condition in which the body does not produce enough, or properly respond to, insulin, a hormone produced in the pancreas. Insulin enables cells to absorb glucose in order to turn it into energy. In diabetes, the body either does not respond properly to its own insulin or does not make enough insulin, or both. This causes glucose to accumulate in the blood, often leading to various complications.
The term diabetes, without qualification, usually refers to diabetes mellitus, which is associated with excessive sweet urine (known as “glycosuria”) but there are several rarer conditions also named diabetes. The most common of these is diabetes insipid us in which the urine is not sweet (insipid us meaning “without taste” in Latin); it can be caused either by kidney or pituitary gland.

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13 December 2012

CONCEPT AND PHILOSOPHY OF TOTAL QUALITY MANAGEMENTS

About Authors:
Amit A. Patel
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA.
amitpatelmx@gmail.com

ABSTRACT:
Quality is critical in achieving competitiveness in domestic and global market. Quality is a journey starting from design, to conformance, and ends at better performance. This process considers quality as a ‘never ending’ improvement. The success of TQM mainly depends on the achievement of internal as well as external customer satisfaction. Internal customer satisfaction is a prerequisite to achieve external customer satisfaction.

If Employees are to identify and correct quality problems, then they have to use some quality tools. Quality circles are also known as work improvement or quality teams. the quality circle is a small group of employees who voluntarily meet at regular times to identify, analyse and solve quality and other problems in their working environment.
12 December 2012

A REVIEW ON QUALITY CONTROL OF HERBAL DRUGS

About Authors:
R.C. Gedar¹*, Rakesh Sharma², Sanjeev Sharma²
¹Seth G. L. Bihani S. D. college of technical education, IPSDR, Sriganganagar (Raj.)
²J. C. D. M. Pharmacy College, Sirsa (Hry.)
*rcgedar@gmail.com

Abstract
This review highlights the current advances in knowledge about the safety, efficacy and quality control of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and hasthus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that herbal drugs are safe and free from side effects is false.