Anand

GLOBAL SCENARIO OF HERBAL DRUG TODAY AND TOMORROW

About Authors:
1Bhatt Mehul K.*, 2Dr. Captain A.D.
1Department of Pharmacognosy,
Shivam Pharmaceutical Studies & Research Centre,
Valasan-388 326, Anand, Gujarat, India.
2Department of Pharmaceutical chemistry
A. R. College and G. H Patel institute of Pharmacy,
Vallabh Vidyanagar, Anand-380 015, Gujarat, India.
*mkb_0999@yahoo.co.in

Absract:
Today estimate that about 80% of people in developing countries still relays on traditional medicine based largely on species of plants and animals for their primary health care. India has one of the richest plant traditions in the world. These are estimated to by around 25,000 effect plant based formulations, used in folk medicine and known to rural communities in India. Indias share in the export of herbals is USD 63 billion which is just 0.2% of the global herbal market. So there is obviously vast scope for Indian manufacturers for entering the growing worldwide opportunity of business in herbal pharmaceutical field. We also have to focus on standardization of herbal products. Pharmaceutical export promotion council i.e PHARMEXCIL is ready to play a key role in this regards. Currently, a majority of the adverse events related to the use of herbal products and herbal medicines that are reported are attributable either to poor product quality or to improper use. Inadequate regulatory measures, weak quality control systems and largely uncontrolled distribution channels may have been contribution to the occurrence of such events. So Pharmacovigilance of herbal medicines is required.

EVALUATION OF ANTIINFLAMMATORY EFFECT OF Capparis Aphylla Roth. USING EXPERIMENTAL ANIMAL MODELS

ABOUT AUTHORS:
Kanzaria S. H. ,  Patel D. V., Patel K.V., Gandhi T. R.
Anand Pharmacy College.
Anand, Gujarat
*sainikak@yahoo.in

ABSTRACT:
Objective: To evaluate anti-inflammatory effect of Capparis aphylla Roth. (CA) using experimental animal models. Material and method: Female Wistar rats (200 to 250gm) were randomly allocated to six groups (n=6). Except group-I (normal control), arthritis was induced in animals of all groups by injection of 0.2 ml Complete Freund’s Adjuvant (6mg/ml) on day one. Additionally Group III (Std) and Group IV–VI (CA-1, CA-2 and CA-3) received Indomethacin (100mg/kg), CA (300 mg/kg ; 240 mg/kg and 190 mg/kg) from day 1 to day 21 orally. Paw volumes of both sides (measured by plethysmography) was recorded  on day 0, 7, 14, 21. On 7th, 14th, 21stdays the severity of the secondary lesions was evaluated by measuring body weight, arthritic index, Erythrocyte Sedimentation Rate(ESR), Rheumatoid factor(RF), C- Reactive Protein(CRP), Albumin/Globulin(A/G) ratio, X-ray, histopathology of synovial joints. Result: Capparis Aphylla Roth. significantly prevented the freund’s adjuvant induced changes in body weight, serum A/G ratio , arthritic Index, paw edema, ESR, RF, CRP. the results were comparable with the standard drug indomethacin. Conclusion: Antiinflammatory activity of Capparis aphylla Roth. can beattributed to COX-II inhibition leading to decrease in inflammatory mediator.

Require Professors, Associate Professors & Assistant Professors in Anand Pharmacy College

Anand Pharmacy College is one of the leading institute of Gujarat, established in 1998 under the aegis of Shri RamKrishna Seva Mandal. The institute has been established with a view to promote excellence in Pharmacy education and to prepare upcoming generation to meet the challenges in the area of Pharmaceutical industries, education, research and development by utilizing leading edge technologies with available resources at the APC.

HEALING ANXIETY WITH HERBS

About Author:
Bhatt Mehul K,
Asst.professor, PhD continue
Department of Pharmacognosy,
Shivam Pharmaceutical Studies & Research Centre,
Valasan-388 326, Anand-380 015, Gujarat, India.
mkb_0999@yahoo.co.in

Abstract:
Now-a-days many people of the world are suffering from anxiety, stress and depression. They experience feelings of anxiety before an important event such as exam, business deal or first date. Anxiety disorders however are illness that fills peoples lives with unreal & imaginary fear that are chronic, unremitting and can grow progressively worse. By now, most of us know that anxiety is quite a common complaint and many people have tried some of the various medications used for anxiety. But many don’t know that there are a variety of herbs available used to treat anxiety in natural way. This article includes, “What is Anxiety?” Herbs used to cure Anxiety, depression, and Stress”, and “Natural Self-Healing”.

EFFECT OF LYOPHILIZATION AND CRYOPRESERVATION ON PLANT LEAVES OF TERMINALIA ARJUNA TERMINALIA CATAPPA, TERMINALIA CHEBULA, JATROPHA GOSSYPIFOLIA, JATROPHA CURCAS

About Authors:
1Hardik R. Patel*, 2Upanita C. Patel
1Industrial biotechnologist, 2Microbiologist
Anand, Gujarat, India.
*hardikigbt@gmail.com

INTRODUCTION:
Cryopreservation and lyophilization of plant germplasm has obvious advantages over in vitro storage in term of space saving and improved phytosanitation. We compared cryopreserved and lyophilized leaf as sources for genomic DNA isolation by CTAB protocol and PVP protocol.Our results showed that cryopreservation of leaf tissue yielded high molecular weight genomic DNA. The DNA was suitable for restriction-enzyme digestion and as a template for polymerase chain reaction (PCR) amplification. While these results rule out cryopreserved  tissue as a source for DNA isolation, the ability to freeze-dry, powder, and efficiently store voluminous tissue samples for later use in DNA and protein isolation could be of great benefit to laboratories involved in  molecular genetics and molecular biology.

FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE MODIFIED RELEASE DOSAGE FORMS

About Author:
*1 Patel Dimpalben Girishkumar, 2 Mr.K.H.Shah, 3 Rohit K Patel,
3Yatish Shukla, 3 Modi B, 3 Nilesh Patel
1 Dharmaj Degree Pharmacy College,

Dist- Anand, Dharmaj -388430, Gujarat
2 Professor, IPCPRC, Dharmaj, Gujarat
3 KAPTAB Pharmaceuticals
*dimplepatel70@gmail.com

Abstract
The aim of the current investigation is to design oral once daily modified  release dosage forms of amoxicillin trihydrate for treatment of pharyngitis/tonsilitis,  which release the drug for 24 hours and match with theoretical drug release profile.  The tablets and capsules were prepared by the different method using different  polymers in different concentrations. The interference of the polymers was ruled out  by FT-IR spectroscopy studies. The powder-blends of tablets and drug were evaluated  for their physical properties like angle of repose, bulk density, compressibility  index, and Hausner ratio and found to be satisfactory. The manufactured tablets  were evaluated for in process and finished product quality control tests including  appearance, thickness, weight variation, hardness, friability, drug content, and in  vitro drug release. All formulations showed appearance, thickness, weight variation,  hardness, friability and drug content in specified limit. All formulations showed  acceptable pharmacotechnical properties and complied with in-house specifications  for tested parameters. The results of dissolution studies indicated that formulation  containing 50% ethyl cellulose and 50% methocel was the most successful  formulation which was evidenced by similarity (f2) and dissimilarity (f1) factors. The  formulated amoxicillin trihydrate tablets followed zero order release kinetics and  Higuchi diffusion was the dominant mechanism of drug release, resulting in regulated  and complete release within 24 hours. Formulations were subjected to short term  stability studies as per ICH guidelines and were found stable. Capsule formulations  16  were evaluated for weight uniformity, drug content and in vitro drug release. The  results of dissolution studies indicated that drug release from capsule not extend up to  24hrs. All formulations of capsule failed in in-vitro drug release test. In comparison of  tablet and capsule formulations, tablet found to be successful dosage form.

Simultaneous Estimation of Tramadol HCl, Paracetamol and Domperidone in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric method

About Authors:
Keyur B.ahir, Emanual M. Patelia*, Falgun A.Mehta
Department of Pharmaceutical Chemistry and Analysis,
Indukaka Ipcowala College of Pharmacy,
New Vallabh Vidyanagar – 388121, Gujarat, India
*ricky.emanual@gmail.com

Abstract:
A simple, precise, rapid, selective, and economic high-performance-thin-layer chromatography (HPTLC) method has been established for simultaneous analysis of Domperidone (DMP), Paracetamol (PCM) and Tramadol Hcl (TMD) in tablet dosage forms. The chromatographic separations were performed on precoated silica gel 60254 plates with toluene-ethylacetate-butanol-ammonia 5:4:1:0.2(v/v) as mobile phase. The plates were developed in a 7.0 cm at ambient temperature. The developed plates were scanned and quantified at their single wavelength of maximum absorption at approximately 278 nm for DMP and PCM, respectively. Experimental conditions such as chamber size, chamber saturation time, migration of solvent front, slit width, etc. were critically studied and the optimum conditions were selected. The drugs were satisfactorily resolved with Rf 0.18 ± 0.02 for DMP, Rf 0.25 ± 0.02 for PCM and for TMD Rf 0.50 ± 0.02. The method was validated for linearity, accuracy, precision, and specificity. The calibration plot was linear between 100-600 ng / band for DMP, 3250-19500 ng / band based for PCM and 375-2250 ng / band based for TMD. The limits of detection and quantification for DMP were 9.95 and 30.16ng / band, respectively; for PCM they were 64.30 ng and 194.87 ng / band and for TMD 5.51 and 16.70/ band. This HPTLC procedure is economic, sensitive, and less time consuming than other chromatographic procedures. It is a user-friendly and importance tool for analysis of combined tablet dosage forms.

Synthesis and Antimicrobial activity of Bulky molecules comprising Benzothiazole and Sulphonamide moieties

About Authors:
Pritesh R. Patel*, Priyank Patel, Jagath Pillai, Nilesh Darji, Bhagirath Patel
Department of Pharmaceutical Chemistry,
Sat Kaival College of Pharmacy, Sarsa,
Ta & Dist: Anand (Gujarat), India-388365

*prit.pharma@gmail.com

ABSTRACT
As part of ongoing studies in developing new antimicrobials, a novel series of 4-acetamido-N-(substituted 1, 3-benzothiazol-2-yl) benzenesulphonamide and N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide were synthesized in order to determine their antibacterial and antifungal activity. The synthesized compounds were tested in vitro against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis; two Gram-negative bacteria like Escherichia coli, Pseudomonas aeruginosaand one fungal strain Candida albicans in comparison with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial and antifungal activity against the tested microorganisms. The compounds with a 6-chloro (SK5b), 7-chloro-6-fluoro(SK5d) and 6-nitro (SK5e) on 2-amino benzothiazole ring possessing azo linkage showed better antimicrobial activity; almost similar or less to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocyclic derivatives were characterized by Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, 1H NMR and Mass spectroscopy).

Faculty vacancies in A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy AND Indukaka Ipcowala College of Pharmacy - 16 vacancies

Set up in 1981 with generous donation from Shrimati Anjanaben Ashokbhai Shah and Shri Gordhanbhai Hathibhai Patel the institutions offer the following courses:
D.Pharm, B.Pharm, M.Pharm (Eligibility for admission is minimum of 60% marks in B. Pharm.) (Eligibility for admission is M. Pharm.) Main areas of pharmaceutical sciences covered are Pharmaceutics and Pharmaceutical Technology, Pharmaceutical Chemistry & Pharmaceutical Analysis, Pharmacology & Toxicology and Pharmacognosy & Phytopharmaceuticals.

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