Anand

Pharma Courses
  • PharmaTutor
    26 October 2012

    FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE MODIFIED RELEASE DOSAGE FORMS

    About Author:
    *1 Patel Dimpalben Girishkumar, 2 Mr.K.H.Shah, 3 Rohit K Patel,     3Yatish Shukla, 3 Modi B, 3 Nilesh Patel
    1 Dharmaj Degree Pharmacy College,
    Dist- Anand, Dharmaj -388430, Gujarat
    2 Professor, IPCPRC, Dharmaj, Gujarat
    3 KAPTAB Pharmaceuticals
    *dimplepatel70@gmail.com

    Abstract
    The aim of the current investigation is to design oral once daily modified  release dosage forms of amoxicillin trihydrate for treatment of pharyngitis/tonsilitis,  which release the drug for 24 hours and match with theoretical drug release profile.  The tablets and capsules were prepared by the different method using different  polymers in different concentrations. The interference of the polymers was ruled out  by FT-IR spectroscopy studies. The powder-blends of tablets and drug were evaluated  for their physical properties like angle of repose, bulk density, compressibility  index, and Hausner ratio and found to be satisfactory. The manufactured tablets  were evaluated for in process and finished product quality control tests including  appearance, thickness, weight variation, hardness, friability, drug content, and in  vitro drug release. All formulations showed appearance, thickness, weight variation,  hardness, friability and drug content in specified limit. All formulations showed  acceptable pharmacotechnical properties and complied with in-house specifications  for tested parameters. The results of dissolution studies indicated that formulation  containing 50% ethyl cellulose and 50% methocel was the most successful  formulation which was evidenced by similarity (f2) and dissimilarity (f1) factors. The  formulated amoxicillin trihydrate tablets followed zero order release kinetics and  Higuchi diffusion was the dominant mechanism of drug release, resulting in regulated  and complete release within 24 hours. Formulations were subjected to short term  stability studies as per ICH guidelines and were found stable. Capsule formulations  16  were evaluated for weight uniformity, drug content and in vitro drug release. The  results of dissolution studies indicated that drug release from capsule not extend up to  24hrs. All formulations of capsule failed in in-vitro drug release test. In comparison of  tablet and capsule formulations, tablet found to be successful dosage form.

  • 20 July 2012
    Synthesis and Antimicrobial activity of Bulky molecules comprising Benzothiazole and Sulphonamide moieties

    About Authors:
    Pritesh R. Patel*, Priyank Patel, Jagath Pillai, Nilesh Darji, Bhagirath Patel
    Department of Pharmaceutical Chemistry,
    Sat Kaival College of Pharmacy, Sarsa,
    Ta & Dist: Anand (Gujarat), India-388365
    *prit.pharma@gmail.com

    ABSTRACT
    As part of ongoing studies in developing new antimicrobials, a novel series of 4-acetamido-N-(substituted 1, 3-benzothiazol-2-yl) benzenesulphonamide and N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide were synthesized in order to determine their antibacterial and antifungal activity. The synthesized compounds were tested in vitro against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis; two Gram-negative bacteria like Escherichia coli, Pseudomonas aeruginosaand one fungal strain Candida albicans in comparison with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial and antifungal activity against the tested microorganisms. The compounds with a 6-chloro (SK5b), 7-chloro-6-fluoro(SK5d) and 6-nitro (SK5e) on 2-amino benzothiazole ring possessing azo linkage showed better antimicrobial activity; almost similar or less to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocyclic derivatives were characterized by Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, 1H NMR and Mass spectroscopy).

  • 25 January 2012
    Faculty vacancies in A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy AND Indukaka Ipcowala College of Pharmacy - 16 vacancies

    Set up in 1981 with generous donation from Shrimati Anjanaben Ashokbhai Shah and Shri Gordhanbhai Hathibhai Patel the institutions offer the following courses:

  • 7 December 2011
    Opening for Pharmacist & Pathologist in Charotar University of Science and Technology

    Charotar University of Science and Technology (CHARUSAT) is established with a vision to become a dynamic global institution in knowledge economy through excellence and impact of teaching, research and social contribution. It follows the mission to serve the society by striving to transform it through creation, augmentation, dissemination and perpetuation of knowledge.

  • 9 March 2011
    Multiplace Vacancies in Unichem for the post of Business Executive - Gynec Division | all India level

    Unichem Laboratories has grown to become one of India’s most respected pharmaceutical companies. It is committed to delivering better health through superior products. By combining strategic research and in-depth industry knowledge, Unichem aims to transform itself into a global pharmaceutical drug company with an increasing focus on cutting-edge research and developed markets.

  • 1 December 2010
    Teaching & nonteaching staff require in Sardar Patel College of Pharmacy | Principal, Professors, Assistant professors & Lecturers (in various dept.)

    Sardar Patel University comprises of 25 Postgraduate Departments, a constituent collage, and number of colleges affiliated to it. There are 14 PG Centers in the affiliated Colleges, linstitutions. The teaching programme covered at Postgraduate, Medicine, Homeopathy, Home Science, Law and Education includes Postgraduate Degree Courses, Postgraduate Diploma Courses, Diploma Courses, and Advanced Certificate Courses, Undergraduate Courses are taught in the colleges or institutes affiliated to the University.

  • 14 August 2010
    Multiple Vacancies in Cadila Pharma as Medical Representative

    Cadila Pharmaceuticals Ltd. (CPL) Is one of India’s most reputed, research-based, techno-savvy pharmaceutical companies with a focus in the area of Formulations & APIs and having its Corporate Office at Bhat, Ahmedabad and State-of-art manufacturing facilities at Dholka, Ankleshwar, Kadi and Jammu accredited with USFDA, MHRA, TGA, MCA, MCC & WHO certifications. The present volume of the group is Rs.

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