Ahmednagar

FORMULATION AND EVALUATION OF SR RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM BY USING CHITOSAN AS A NATURAL POLYMER

About Authors:
Garje V.A1, Nagargoje S.S1, Phanse V.R1, Kshirsagar R.R1
1Dept.of Pharmaceutics. S.V.N.H.T’S College Of B.Pharmacy Rahuri Factory,
Rahuri.413706 MS,India.
*vishnugarje02@gmail.com

ABSTRACT
The objective of present study was to develop an oral sustained release dosage form of diclofenac sodium, with chitosan as an sustained release polymer, and to evaluate the prepared dosage form for physical parameters, like weight uniformity, hardness, friability, and drug content. Chitosan a natural polymer, compatible with physiologic environment, possessing sustained release matrix forming characteristics and binding properties. It was used to prepare sustained release matrix tablets. In the present study, the influence of different concentrations of polymer on erosion of matrix system was studied, with a view to develop sustained release formulation of diclofenac sodium.The diclofenac sodium tablet were prepared by wet granulation method,with a solvent such as distilled water, lactose was used as diluents, talc1% was used as lubricant. The result from in-vitro drug release studies indicated that the formulations batch-2&batch-3,with polymer concentrations 1:1.1&1:1.3 resp. Prepared by wet granulation using distilled water as a solvent, were found to be release the drug at a steady state over an extended period of time upto 24 hrs.

ARTIFICIAL VIRAL ENVELOPES: EMERGING VEHICLE FOR GENE DELIVERY

About Authors:
AMOL D.GHOLAP*1, DATTATRAY TUPE2
1Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College,
Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
2Department of Regulatory Affairs, Lupin Limited,
Kalina, Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstract
The several evolutions in the field of medicine develop different cellular mechanisms for striking along with entering the target cells with efficiency. The utilization of recombinenet adenovirus as carriers for cDNA induces dose along with therapy limiting of defense mechanisms. Artificial viral envelopes (AVE) are lipid vesicles which mimic with fusogenic envelop of retrovirus to utilize as target selectivity along with efficiency of delivery of viruses. The major component of AVE includes phosphatidylcholine, phosphatidyiserine along with sphingomyelins. The negative charge is present on AVE’s help them for targeting the moieties such as viral binding proteins. The artificial viral envelopes show potential applications in plasmid delivery.

COLLOIDOSOMES: A POTENTIAL DRUG DELIVERY SYSTEM

About Authors:
AMOL D.GHOLAP*1, DATTATRAY TUPE2
1 Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College, Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
2 Department of Regulatory Affairs, Lupin Limited, Kalina,
Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstracts
There are several newer lipid based systems are evoked and utilized now a days as dryg delivery systems like liposomes, transferosomes, ethosomes etc which provides effective solutions for problem regarding insolubility, instability, rapid degradation along with has wide application in the specialized area consisting protein delivery, targeting to the brain, and tumor targeting. This lipid based systems also utilized in for gene delivery with efficient performance while in this field the colloidosomes evoked as potential tool based on the vascular drug delivery system. There are several applications of vascular systems are present including reduction in the cost of therapy via improved bioavailability of medication generally in the case of poorly soluble drugs. The colloidosomes have several beneficial advantages like greater encapsulation efficiency with wide control on the size along with permeability and compatibility. The colloidosomes also have effective mechanical strength.

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