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DEVELOPMENT OF IBUPROFEN-LOADED EMULSION FROM EUTECTIC MIXTURE AND EUDRAGIT RL 100

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ABOUT AUTHORS
T. Raja Sekharan1*, Shunmugaperumal Tamilvanan2, S. Rajadurai1, S. Mohammed Ibrahim1 and K. Kavipriya
1 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam-626130, Sivakasi, Tamil Nadu, India.
2National Institute of Pharmaceutical Education and Research (NIPER)‑Guwahati, C/O NETES Institute of Technology and Science, NH‑37, Shantipur, Parli Part, Mirza, Assam 781125, India

ABSTRACT
The main objective of this study was to formulate an Ibuprofen loaded emulsion from the eutectic mixture and Eudragit RL 100. The eutectic mixture was formed with camphor and menthol which was approved by the FDA. A eutectic mixture is defined as a combination of two or more components at a certain ratio intermingle to form a new chemical compound resulting in a system having a lower melting point than either of the components. The formulated emulsion from the eutectic mixture was evaluated for various studies like pH checking, stability checking by centrifugation, viscosity, particle size analysis, quantitative drug analysis, thermodegradation and in-vitro drug release studies. Neutral pH values resulted in the formulations. The formulation was stable even after it was centrifuged for 5000 rpm for 30 min. Viscosity results showed the formulation was less viscous results in good spreadability. Particle size was determined with particle size analyzer. Drug analysis results revealed about 96 % of drugs are incorporated into the formulation. Thermodegradation results proved that there was no spillage of drugs from the formulations even when the drug was stored at different temperatures. In-vitro drug release study was performed by varying drug concentrations. The results showed there was no change in the drug release even after varying the drug concentration. From the results it was concluded that Ibuprofen was successfully formulated as an emulsion with the help of eutectic mixture a Eudragit RL 100.

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