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  • PharmaTutor
    22 April 2014

    Working opportunity in Mylan as Head of Quality Systems & Compliance, Injectables

    Mylan is one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in more than 150 countries and territories. The company maintains one of the industry’s broadest and highest quality product portfolios, which is regularly bolstered by an innovative and robust product pipeline. With a workforce of more than 16,000, Mylan has attained leading positions in key international markets through its wide array of dosage forms and delivery systems, significant manufacturing capacity, global commercial scale and a committed focus on quality and customer service.

    Post: Head of Quality Systems & Compliance, Injectables

  • 21 April 2014
    PREPARATION AND EVALUATION OF MATRIX TABLETS CONTAINING AMBROXOL HYDROCHLORIDE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Soma Vinisha*, Sajida Akhtari Begum, Nikhat Tabassum, Soma Anusha
    Department of pharmaceutical science,
    Bharat Institution of Techology, Hyderabad, India
    choti.reddy@gmail.com

    ABSTRACT
    Purpose:     This study aimed to formulate Ambroxol hydrochloride SR matrix tablets using xanthan gum (natural polymer) and to elucidate the release kinetics of Ambroxol hydrochloride from xanthan gum-matrices. Methods: controlled release matrix tablets of ambroxol hydrochloride, a mucolytic expectorant  were prepared by wet granulation method using xanthan gum as natural hydrophilic polymer in three different ratios (Drug : Polymer 1:1(F-1), 1:1.5(F-2), 1:2(F-3)). The prepared granules of three different formulations were evaluated for angle of repose, bulk density (BD), tapped density (TD) and compressibility index (CI), hausners ratio. The prepared tablets were tested for physical parameters like weight variation, hardness, friability, content of active ingredient and In-vitro drug release studies. Results: The results obtained were within the prescribed limits. The release of ambroxol from the matrix tablets was sustained up to 12hrs. The cumulative percentage of drug release was decrease with increase in polymer concentration. Among the three formulations F-3 gave the release profile close to the commercially available marketed sample of ambroxol Hcl (A-MS).The results indicate that the drug release from the matrix tablets followed Zero order kinetics. The dissolution data was fitted to Korsmeyer equation which is used to describe the drug release behaviour from polymeric systems. All the formulations showed diffusion co-efficient value (n) greater than 0.43 but less than 0.85 after fitting to the Korsmeyer equation. So, it indicates Non-Fickian transport mechanism. Therefore the drug release is by diffusion and erosion mechanism. Conclusion: Matrix tablets of Ambroxol Hydrochloride using xanthan gum prepared by wet granulation method were found to be good in appearance. The drug-polymer ratio was found to influence the release of drug from the formulations. Formulation F-3 i.e. (1:2 drug: polymer) exhibited the similar In-vitro drug release rates as that of the marketed sample.

  • 18 April 2014
    Vacancy for Clinical Research Associate in Lonza

    Lonza is one of the world's leading suppliers to the pharmaceutical, healthcare and life science industries. Products and services span its customers’ needs from research to final product manufacture. It is the global leader in the production and support of chemical and biological active pharmaceutical ingredients. Lonza is also the world leader in microbial control providing innovative, chemistry-based and related solutions to destroy or to selectively inhibit the growth of harmful microorganisms. In addition, Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Furthermore, the company is a leading provider of value chemical and biotech ingredients to the nutrition and agro markets.

    Post: Clinical Research Associate-000003HP

  • 16 April 2014
    Looking for Executive Business Development Cum Regulatory @ Evolet Healthcare | | Must be B Pharma/MBA

    "Evolet" is the pioneer in the field of rendering services of outsourcing – in production of pharmaceutical production on the basis of contract manufacturing.

    Post: Executive Business Development Cum Regulatory MALES ONLY- 3

  • 16 April 2014
    Vacancy for Technical Specialist @ DuPont

    For over 200 years, we’ve harnessed our scientific expertise to discover, enable, and deliver solutions for the world at large. Explore DuPont careers to discover how we work together with academics, governments, companies and organizations around the globe to find new and better ways to provide for the needs of our growing population. It’s what we call inclusive innovation.

    Post: Technical Specialist

  • 14 April 2014
    Opening for M.Pharm, M.Sc as Pharma Facilities Manager @ Novartis

    A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

    Post: Pharma Facilities Manager

  • 14 April 2014
    Job for Senior Manager QA- Global Dev QA @ Novartis

    A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

    Post: Sr Mgr QA-Global Dev QA

  • 7 April 2014
    Career as Pharmacist-B in Atomic Minerals Directorate for Exploration & Research

    The prime mandate of Atomic Minerals Directorate for Exploration and Research is to identify and evaluate uranium resources required for the successful implementation of Atomic Energy programme of the country. For implementing this important task investigations are taken up across the length and breadth of the country from Regional Exploration & Research Centres located at New Delhi , Bengaluru, Jamshedpur, Shillong, Jaipur, Nagpur and Hyderabad (Headquarter & South Central Region).

    Applications are invited ONLINE from eligible candidates for appointment to the following posts for appointment in Atomic Minerals Directorate for Exploration & Research (AMD):

    Post: Pharmacist-B

  • 3 April 2014
    Opening for post of Manager-Database Operations @ Novartis

    A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

    Post: Manager-Database Operations

  • 3 April 2014
    UGC project entitled “Pharmacogenetic Response to Statins in Atherosclerosis” in Osmania University

    Osmania University established in 1918, is the seventh oldest in the Country, third oldest in South India and the First in the princely state of Hyderabad. The establishment of Osmania University symbolizes a renaissance in the Indian Educational System and has shown a remarkable resilience throughout its existence. The university is instrumental in propagation of Higher Education to cater the needs of community in the region over nine decades and has grown into one of the major Universities of India. It has a vast sprawling green campus of 500 hectares set in picturesque and idyllic surroundings. It owns number of buildings of great architectural elegance and variety to enhance the beauty of the campus. The university is an autonomous institution created through an act of legislature and most part of funding is from the State Government. The university holds the flagship for Higher Education of Government of Andhra Pradesh and has played a key role in planning, initiating and implementation of various development programs.

    Post: Project Fellow

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