Career opportunity for a Project Leader in Molecular Modeling of Computer-Aided Drug Design in ILS

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Institute of Life Sciences (ILS) is a not-for-profit research institute that aims to conduct innovative research in unifying areas of chemistry, biology and chemical biology. We currently have a career opportunity for a Project Leader in Molecular Modeling of Computer-Aided Drug Design, starting Q2-2011.

Post: Project Leader

The successful candidate will employ CADD technologies in support of drug discovery project of an internationally renowned funding organization. The candidate will work closely with the multidisciplinary drug discovery team (Medicinal Chemistry, Biology, Pharmacology, etc.) at ILS, and collaborate with international partners. In this role, the Project Leader suggests and develops new approaches to the identification and optimization of the small molecules hits as leads for a contemporary therapeutic target.

Candidates should at least possess a Ph.D. degree in computational chemistry or computational biology with at least two-year pharmaceutical industry or relevant postdoctoral experience, preferably with CADD paradigms. Candidates should also possess knowledge and comprehension of role of CADD in drug discovery. A proven track record in the use of standard CADD approaches such as experience in protein modeling, structural analysis, binding site mapping, docking and post-docking analysis, library design/ranking, and virtual screening). Demonstrate skills in the fields of molecular dynamics (knowledge and experience of QM/MM). Show know to how in the field of molecular descriptors, pharmacophore, fingerprints, and structure-activity relationships. Demonstrated expertise in handling/maintenance of large databases, clustering, QSAR, and ADMET optimization is beneficial.
Strong programming skills in two or more of the following: C, C++, Perl, Python, UNIX, Linux, and shell scripting are required. Should be self-motivated, proactive, and a team player. Excellent written and oral communication skills are required.

How to Apply:-
Salary and emoluments are commensurate to the qualification and expertise but limited
to the conditions of funding. The position is initially for three years and extendable upon mutual agreement and extension of the project.

Please apply by email with a CV and cover letter to or before 25th February, 2011.

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