About Authors: Venkata Suresh Babu Aluri*
Department of pharmaceutical Analysis,
Adhiparasakthi College of Pharmacy,
Melmarvathur, Kancheepuram District, Tamil Nadu - 603319 (INDIA)

Reference ID: PHARMATUTOR-ART-1077

Abstract
A simple, specific, sensitive, rapid, precise and economical high performance liquid chromatography (HPLC) method has been developed for the estimation of Olmesartan medoxomil (OLM) and Atorvastatin calcium (ATC) in tablet dosage form by using acetonitrile- phosphate buffer pH 3.0 (40:60 v/v) as a solvent system. The method was carried out on a Phenomenex Gemini C18 (15 cm x 4.6 mm i.d., 5µm particle size) column, at flow rate 0.9 mL/min. Detection was carried out at 252 nm. The retention time of OLM and ATC was 3.19 and 4.63 min, respectively. The two drugs follow Beer-Lambert’s law over the concentration range of 8 – 40 µg/mL for OLM and 4 – 20 µg/mL for ATC. Validation of proposed method was carried out for its accuracy, precision, specificity and ruggedness according to ICH guidelines. The proposed method can be successfully applied in routine work for the determination of Olmesartan medoxomil and Atorvastatin calcium in combined dosage form.

Glenmark Pharmaceuticals today announced the settlement of litigation with Daiichi Sankyo and Genzyme Corporation regarding Glenmark's Abbreviated New Drug Application (ANDA) tiled with the US Food and Drug Administration (FDA) for Colesevelam Hydrochloride, a drug used in treatment of type-2 diabetes.

The journey of Yashoda Hospitals started way back in 1989 as a small clinic, where Dr G Surender Rao practised paediatrics. With his international education and experience he became one of Hyderabad’s leading child specialists in a short span of time. Not satisfied with personal success he joined forces with his brother, Mr Ravinder Rao, an experienced business leader, to start Yashoda Hospitals.

Indian Institute of Technology – Roorkee is among the foremost of institutes of national importance in higher technological education and in engineering, basic and applied research.

Glenmark Pharmaceuticals today announced the settlement of litigation with Daiichi Sankyo and Genzyme Corporation regarding Glenmark's Abbreviated New Drug Application (ANDA) tiled with the US Food and Drug Administration (FDA) for Colesevelam Hydrochloride, a drug used in treatment of type-2 diabetes.

The history of Jamia Hamdard begins with the establishment of a small Unani clinic in the year 1906 by Hakeem Hafiz Abdul Majeed, one of the well-known practitioners of Unani System of Medicine of his time. Hakeem Hafiz Abdul Majeed had a vision of making the practice of Unani Medicine into a scientific discipline so that Unani medicines could be dispensed in a more efficacious manner to patients. He gave the name "Hamdard" to his venture which means "sympathy for all and sharing of pain".

Manav Group of Institutes is one of the leading educational group with Manav Institute Mof Technology & Management (Woman), Manav Institute of Education, Manav Institute of Pharmacy under its umbrella. Manav Nirman Samiti is the visionary body and the source of inspiration.

The Indian Institute of Toxicology Research (IITR), established in 1965, a constituent laboratory of Council of Scientific & Industrial Research (CSIR) engaged in the Research & Development in the areas of Environmental Toxicology, Predictive Toxicology, Health Risk Assessment, Preventive Toxicology, Inhalation Toxicology, Analytical Toxicology, and also National S&T Missions. IITR has two campuses; the main campus is located at the centre of Lucknow City and the other campus at a distance of approx.

About Authors: Ashwini K. Reddy, Swetha, Gauthami, Srivally, Masoom - M.Pharm, Helen Sheeba - Assistant Professor. Malla Reddy Institute of Pharmaceutical Sciences, Hyderabad.

Reference ID: PHARMATUTOR-ART-1076

HIGH - THROUGHPUT screening (HTS) is an approach to drug discovery that has gained widespread popularity over the last three or four years. HTS is the process of assaying a large number of potential effectors of biological activity against targets (a biological event). The methods of HTS are applied to the screening of combinatorial chemistry, genomics, protein, and peptide libraries. The goal of HTS is to accelerate drug discovery by screening large libraries often composed of hundreds of thousands of compounds (drug candidates) at a rate that may exceed 20,000 compounds per week. This paper will focus on assay adaptations, robotic equipment, and implementation strategies that allow HTS programs to be successful. Ultrahigh throughput screening (UHTS) issues (testing of 100,000 compounds / day) will also be discussed.

About Authors: Rekha. S^1*
1*Department of Pharmacology, Mother Theresa Postgraduate and Research Institute of Health Sciences, Indira Nagar, Gorimedu, Puducherry 605 006.
Kavimani. S^1
1Professor and Head, Department of Pharmacology, Mother Theresa Postgraduate and Research Institute of Health Sciences, Puducherry.

Reference ID: PHARMATUTOR-ART-1069

Summary
Objective
The present study was undertaken to further evaluate the adverse effect potential of Prulifloxacin to induce arthropathy in rats with reference to its duration of treatment.

Methods
Groups of one month old young rats were administered Prulifloxacin intraperitonially 200 mg/kg and 400 mg/kg doses for 15 and 30 days respectively. Control group received normal saline. At the end of treatment
period, animals in each group were subjected to serum alkaline phosphatase estimation. The serum alkaline phosphatase assay was carried out by using alkaline phosphatase reagent kit.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

Exotic Naturals is a Natural Products R&D company. We develop novel plant products for use in human healthcare and crop health. Since it was founded in 1994, Exotic Naturals has served the needs of the Dietary Ingredients, Herbal Supplements, Phytopharmaceutical and Biopesticide industry in N. America, Europe and Asia-Pacific.

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

About Authors: Parag Ghosh
Bharat Technolgy & West Bengal Universuty of Technology,
B.Pharm

Reference ID: PHARMATUTOR-ART-1067

Abstract
Antioxidant activity of ethanolic extract of C .hirsutus Diels leaves was studied for it free radical scavenging property in different in vitro models as 1, 1- Dipheheny1 – 2 picry1 hydrazy1, nitric oxide, superoxide and hydroxy1 radical model. The extract shows significant dose dependent free content suggesting the plant to exhibit antioxidant activity.