About Authors:
V. Ravi Chandra
Research Associate
Parexel
B.Pharmacy from Priyadarshini College of pharmacy,
Osmania University,
Hyderabad, AP, INDIA

Abstract:
Huntington's disease is an intricate illness. It is a neurodegenerative, insidious disorder-which means it is harmful and fatal but gradually. The onset of the disease is very late to diagnose the disease. Huntington's disease (HD) also called as ‘Huntington’s Chorea’. Chorea means dance in Greek, which is aftereffect of genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. By choreic movement physically we can diagnose HD. HD is also a familial disease, passed from parent to child through a mutation in the normal gene. Attempts to study early disease are not unique in neurology (e.g., mild cognitive impairment and vascular cognitive impairment), but studying otherwise healthy-appearing individuals who have nearly 99% certainty of manifesting the symptoms of brain disease does provide distinct but valuable information about the true natural history of the disease. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. HD occurs in about one out of every 10,000 Caucasian individuals. In India, the cases are unknown because of failure of doctors to diagnose HD as they never seen HD in their practice. Approximately 2.5 times more individuals are at risk for the disorder because of the midlife peak in age at onset.

About Authors:
NIKHIL SAXENA, DR.K.R.PARDASANI, DR.USHA CHAUHAN
MAULANA AZAD NATIONAL INSTITUTE OF TECHNOLOGY,
BHOPAL

ABSTRACT
The electro negativity of the drug directly resembles its chemical nature towards the receptor. In order to achieve the desired response, the effective binding of drug is necessary. Based on the Lock key theory, every drug having a specific structure so that it can bind to a specific receptor. But for designing more efficient a new chemical entity for receptor as compared to the main drug, there is a requirement of some structural changes in the drug (ligand) molecules under structure activity relationship concept. 
Here an attempt has been made to develop Insilco approach to make some structural changes on the basis of point mutation (changes occurs at a particular point) in the antiasthmatic drug namely salbutamol.
The effect of this mutation on binding affinity of the molecule is studied using docking energy (energy involved in orientation of one molecule to a second are when bound to each other to form a stable complex) calculations and logp values. Here eight different structures of the drug found are more electronegative as compared to the main drug candidate. Mutation was made at C-3a position in place of hydrogen. These were analyzed for binding affinity with target receptor. The mutated molecules which have high logp values and less energy are selected for further adme properties studies. Thus after prediction all adme properties and toxicity studies of the mutated drugs, the best mutation was bromine in place of hydrogen at C-3a position.

The University Institute of Pharmaceutical Sciences of the Panjab University is a premier institution of Pharmaceutical Education and Research in the country.

NEEDS PHARMA, We would like to introduce ourselves a WHO - GMP certified manufacturing unit from INDIA willing to turn the milestone in Pharmaceutical era.
We manufacture Tablets, Capsule, Syrups, Suspensions and other formulations and are exporting to various countries across the Globe.

SurgicoMedica is a new company based at chandigarh, manufacturing front line products for each therapeutic segment. Looking for Business development associates on PROFIT / REVENUE SHARING basis. Exclusive legal agreement for marketing in defined areas. Customised products as per market needs.

Post: Business Development Associates

The Government of India, through the Ministry of Human Resource Development (MHRD), and based on the recommendation of Scientific Advisory Council to the Prime Minister, decided to create five undergraduate science universities. One of them is located at Kolkata and was started from 2006.

About Authors:
KAPIL V BIYANI¹, DR.P.S. KAWTIKWAR², N. M. MAHAJAN³
1. M.Pharm, IBSS COLLEGE OF PHARMACY,
BULDHANA ROAD, MALKAPUR (M.S)
2. HOD, SNIOP, PUSAD
3. HOD, IBSS COLLEGE OF PHARMACY,
BULDHANA ROAD, MALKAPUR (M.S)

Introduction^{1, 2, 3, 4, 5, 6, 7, 8}
Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard”and“soft”. The hard capsule is also called “two pieces” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage forms.

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AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand giving employment to more than 2000 people.

At Apollo Health Street, we have a strong tradition and belief that personal satisfaction comes from playing an integral part in an organization. In short, we believe in empowered associates.

AXA Parenterals Ltd is into manufacturing & marketing of Sterile Parenteral preparations, life saving medicines and hospital products.

About Authors:
Dr. M.B.SULOCHANA, PRASHANTH GADGI
Department of Biotechnology,
Gulbarga University,
Gulbarga, Karnataka,India

ABSTRACT
To determine the effect of rhizobium inoculation and nitrogen fertilizer on performance of Green gram, Bengal gram and Groundnut. Investigations were done in pot culture experiment under natural conditions. The research material consists of Green gram, Bengal gram and Groundnut varieties with treatment of seeds and Nitrogen fertilizer at 60kg/ha for green gram and Bengal gram, 120kg/ha for Groundnut. These treatments were compared against control (no inoculation). Data were recorded on Plant Growth parameters (seed germination, nodulation index, plant height at maturity, wet weight and dry weight) and soil nitrogen levels at the end of experiment. Among all treatments plant with seed inoculation was found effective in all three legume varieties compared to soil with nitrogen fertilizer and control.

The Pharmaceutical manufacturing facility of the Medical and Cosmetic Products Company Limited has been established on a 15,000 square meters site in Riyadh's 3rd Industrial Area. Riyadh Pharma is the Company's brand name.

Dr. Kanase Healthcare Pvt. Ltd. is one of the new and fastest growing company. We are giving best Service to Diabetic, Hypothyroid, Hyperthyroid, Anaemic and Arthritic Patients.
At Dr. Kanase Healthcare our mission is to improve Physical health and ultimately Mental & Social Health of People to feel better & Live Longer.
This Mission makes real difference of life of people with our commitment to best healthcare solution to make better tomorrow of human being.

Maharashtra Public Service Commission, under Department of health and sciences with FDA invites online applications for the post of Assistant Commissioner (Drug)

Post: Assistant Commissioner (DRUG)

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ANSWERS of Previous PharmaQUIZ-38:

1.D    2.A    3.C    4.D    5.C

6.C    7.D    8.A    9.A    10.B

The Ministry of Health & Family Welfare, Government of India is setting up these six Autonomous Institutions of National Importance. For Faculty Positions/ Senior Residency applications are invited from Indian Nationals and Persons of Indian Origin holding OCI Status. Regular, Deputation, contractual appointments are open.

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