Articles

Oxytocin is a natural hormone that is released by the brain to help people bond with others. It is the hormone that helps bring on labor during childbirth, and the production of milk in lactating mothers. It is responsible for that strong bond between mother and child. Apart from this, oxytocin has also been found to strengthen the bond between partners during and after sex, and higher production levels can be triggered by many types of touching, such as kissing, cuddling and orgasm.

ABOUT AUTHORS:
Sarthak B. Dave*, Dr. Dipen K. Sureja.
Department of Pharmaceutical Chemistry,
Shree H. N. Shukla Institute of Pharmaceutical Education & Research,
Rajkot, Gujarat, India
*davesarthak@ymail.com

ABSTRACT:
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon a, ß-unsaturated carbonyl system. Mainly chalcone are synthesized by Claisen-schmidt condensation reaction (Cross-aldol reaction). Chalcones are well known intermediates for synthesizing various heterocyclic compounds. Chalcones, precursors of open chain flavonoids and isoflavonoids present in edible plants, and their derivatives have attracted increasing attention due to numerous potential pharmacological applications. They have displayed a broad spectrum of pharmacological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity. The present review highlights the recently synthesized Chalcones and their derivatives possessing important pharmacological activities.

ABOUT AUTHORS:
Venkatesh. J , M. Singaiah Chowdary*, Haritha. D, Anuroop , Dr. V.V.L.N Prasad, Anjani Prasad Reddy. V.
Department of Pharmaceutical Analysis and Quality assurance,
School of pharmacy, Anurag Group of Institutions, Venkatapur (V).
Ghatkesar (M), Rangareddy (D)
*chowdary.mannam1@gmail.com

About Authors:
*Rohit Kumar, Mr. Vijay Sharma, Mr. Sunil Kumar
KNGD Modi Institute of Pharmaceutical Education and Research
Modinagar, Ghaziabad
*rohitkmr884@gmail.com

ABOUT AUTHORS:
Dhakar K Mukesh*, Dashora Ahok, Kumar Neeraj
Geetanjali Institute of Pharmacy,
Udaipur
*dhakarmukesh03@yahoo.com

ABOUT AUTHORS:
Vivek P. Chavda*, Maunit B. Mehta, Hamir B. Vala, Nirav A. Pandya
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
*vivek7chavda@gmail.com

ABOUT AUTHOR:
Mr. Vivek P. Chavda, Dr. Moinuddin M. Soniwala
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
vivek7chavda@gmail.com

INTRODUCTION^1,2
In recent years, many important initiatives have been undertaken by regulatory authorities and industry associations to promote international harmonization of regulatory requirements. International Conference on the Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) was organized in April 1990 and has as its sole and primary purpose the creation of international standards for the purpose of pharmaceutical research. This process was initiated in order to harmonize the submission requirements for new pharmaceuticals in the three main regions of Europe, the United States, and Japan and to avoid duplication, inefficiencies and delays.

The six cosponsors of ICH were

1. European Commission,
2. European Federation of Pharmaceutical Industry Association (EFPIA),
3. Japanese Ministry of Health (MHW),
4. Japanese Pharmaceutical Manufacturers Association (JPMA),
5. Food and Drug Association (FDA), and the Pharmaceutical Research
6. Manufacturers of America (PhRMA)