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  • GREENER ITINERARY TO THWART PHARMACY - EFFLUENCE

    ABOUT AUTHOR:
    Raaz K Maheshwari
    Department of Chemistry, SBRM PG Govt College,
    Nagaur, Rajasthan
    drraazgreenchemacs@gmail.com

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    ABSTRACT
    The use of PPCPs is on the rise on the globe. PPCPs enter into the environment through individual human activity and as residues from manufacturing, agribusiness, veterinary use, and hospital and community use. Individuals may add PPCPs to the environment through waste excretion and bathing as well as by directly disposing of unused medications to septic tanks, sewers, or trash. Because PPCPs tend to dissolve relatively easily and don’t evaporate at normal temperatures, they often end up in soil and water bodies. Some PPCPs are broken down or processed easily by a human or animal body and/or degrade quickly in the environment. However, others do not break down or degrade easily. The likelihood or ease with which an individual substance will break down depends on its chemical makeup and the metabolic pathway of the compound. Varying concentrations of drugs found in water sources can have ill effect on the aquatic life and human health. For pharmaceutical pollution, the solution calls upon all health care sectors to participate in preventing pharmaceutical pollution. Green Pharmacy aims at zero pharmaceutical waste in our environment. It offers an opportunity for social action that will greatly benefit our environment at all levels of our society. It encourages health providers and clients to focus on healthy lifestyle and prevention to ensure their well-being through regular wellness practices. It provides education and opportunity for everyone involved with the life cycle of medicine to participate in reducing pharmaceutical pollution. With relatively simple yet firm commitments to change our habits, becoming stewards of medicine rather than consumers of medicine we effectively become part of the solution. This review paper delineates about the powerful approaches of green pharmacy that provides comprehensive solution to pharmaceutical pollution affecting much of well being on globe. Research to date points to the ubiquity of PPCPs in aquatic environments. Existing wastewater treatment facilities are inadequate and aren’t designed to remove them from the waste stream. Our current system of quantifying their toxicological effects is inadequate. Now is the time to prevent further harm to living organisms and the environment.

  • AN OVERVIEW ON PULSATILE DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Edukondalu.Vanka*, M. Jhansi Rani, A.M.Sudhakar Babu, P.Venkatesawara Rao
    Department Of Pharmaceutics,
    A.M. Reddy Memorial College of Pharmacy,
    Narasaraopet, Guntur (district), Andhra Pradesh
    7yedu7@gmail.com

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    ABSTRACT:
    Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery System. Among them Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. The drug delivery is designed according to the circadian rhythm of body. System is suit for the drugs which shows high first pass effect. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like  Time controlled pulsatile release systems, Stimuli-induced pulsatile release system, Externally regulated pulsatile release system, Multiparticulate regulated pulsatile release system have been dealt with in the article. These delivery occurs at predetermined lag time. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arhythmic and anti-asthmatic.

  • ACUTE CORONARY SYNDROME(ACS)-DETAILS REVIEW

    ABOUT AUTHOR:
    Amitava Sinharay
    B.Pharm
    India
    a.amitava.s@gmail.com

  • SUSTAINED OPHTHALMIC DELIVERY OF MOXIFLOXACIN HYDROCHLORIDE AND KETOROLAC TROMETHAMINE FROM AN ION ACTIVATED IN-SITU GELLING SYSTEM

    ABOUT AUTHOR:
    Arya K.R.
    Department of Pharmaceutics, Regional Institute of Medical Sciences and Research,
    MG University, Kottayam
    aryajithu@yahoo.com

  • DRUG EXCIPIENT COMPATIBILITY STUDIES USING THERMAL METHODS

    ABOUT AUTHORS:
    Sandeep Kumar Patro*, M.Jhansi, Dr.A.M.S.Sudhakar Babu, Sk.Asief, P.Ramesh Babu
    A.M.Reddy memorial college of pharmacy, Narasaraopet.
    Sandeepkumarpatro2@gmail.com

    ABSTRACT
    Study of drug - excipient compatibility is an important process in development stage of dosage forms. Incompatibility between drugs and excipients alter drug stability and bioavailability &there by affect their safety and efficacy. Dosage form is a pharmaceutical drug delivery system, which is a combination of drug(s) and non-drug  components called as excipients. Drug is a chemical substance obtained from either natural, synthetic or semi synthetic source, which is used for the treatment, curing, prevention  or mitigation of a disease or disorder in human beings or animals Excipients are nondrug components which are serve specific purposes like shape, stability, solubility, elegance, palatability etc. of a dosage form. These are also called as adjuvants, additives or pharmaceutical aids. The evaluation of drug-excipient compatibility is therefore an essential aspect of any preformulation study. To evaluate the drug- excipient compatibility different techniques such as  Thermal analysis, Differential scanning  calorimetric (DSC) study, Infra red spectrophotometric study (IR), Isothermal stress testing (IST), High performance liquid chromatography (HPLC),Thin layer chromatography (TLC), Solution calorimetry  were adopted.

  • FREGOLI SYNDROME

    ABOUT AUTHOR:
    Jyotirmoyee Patnaik
    Kanak Manjari Institute of pharmaceutical Sciences
    Rourkela, Orissa
    patnaik.jyotirmoyee@gmail.com

    ABSTRACT:
    During the past 80 years, delusional misidentification syndromes (DMS), especially the Fregoli a syndromes, have posed challenges to mental health professionals due to a lack of comprehensive understanding of the syndromes and a lack of effective treatment. During the past two decades, neurophysiological and neuroimaging studies have pointed to the presence of identifiable brain lesions, especially in the right front parietal and adjacent regions, in a considerable proportion of patients with DMS. Prior to the advent of such studies, DMS phenomena were explained predominantly from the psychodynamic point of view. Deficits in working memory due to abnormal brain function are considered to play causative roles in DMS.

  • NANOSUSPENSION, A NOVEL DRUG DELIVERY SYSTEM VIA, NOSE TO BRAIN DRUG DELIVERY

    About Authors:
    N.V. Sateesh Madhav, Abhijeet Ojha, Pallavi Uniyal, Dheeraj Fulara*
    DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
    Uttarakhand, India.
    *fularadheerajmpharm@yahoo.com

  • PHYTOCHEMICAL ASSESSMENT OF THE AQUEOUS AND METHANOLIC EXTRACTS OF SOME HERBAL PLANTS IN JOS, NIGERIA

    About Authors:
    Enegide Chinedu*, David Arome, SolomonF. Ameh
    Department of Science Laboratory Technology (Physiology & Pharmacology Technology),
    University of Jos, Jos Nigeria.
    chinex.snow@gmail.com

    Abstract
    Phytochemicals are referred to as pharmacologically active substances which are naturally present in plants. However, the effects of various plant preparations in the body when administered, is dependent on the phytochemicals present. Herbal medicine have been said to be the oldest form of medicine and have of recent even gained new momentum due to its advantages.The World Health Organization has recognized that traditional herbal plants may be useful in an integrated health care deliverysystem in several countries. But however to achieve the goal of using both herbal medicine and modern medicine paripassu, there is need for the phytochemical assessment of the plants coupled with pharmacological and toxicological investigations as well. Therefore, the aim of this research is to evaluate the phytochemicals present in the aqueous and ethanolic extracts of some herbal plants in Jos, Nigeria. This study have unveiled the presence of various phytochemcals in the different plant extracts examined. The various phytochemicals present in the extracts includes alkaloids, saponins, tanins, flavonoids, carbohydrates, steroids, cardiac glycosides and anthraquinones. These phytochemicals are known to posses therapeutic and also physiological activity. The test have shown that the plants are useful as they contain phytochemicals capable of producing valuable pharmacological effects. However, further studies aimed at establishing the dosage in which the may produce their pharmacological effects and toxicity should be done. Studies aimed at isolating the phytochemicals and screening their individual effects will also be very useful.

  • RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA

    ABOUT AUTHOR:
    Akshay Rajgaria
    Kanak Manjari Institute of Pharmaceutical Sciences
    Rourkela, Orissa
    akshaykrish2007@gmail.com

  • DESIGN, DEVELOPMENT AND CHARACTERIZATION OF pH SENSITIVE HYDROGEL FOR INTESTINAL DELIVERY OF PREDNISOLONE

    ABOUT AUTHORS:
    Patel Juhi D.*, Dr. A.K.Seth, Sachin P Chauhan, Nirmal Shah, Ankur Javia, Chintan Aundhia
    Department of Pharmacy, Sumandeep Vidyapeeth University,
    At & Po Pipariya, Ta- Waghodia, Dist. Vadodra-391760.(Gujarat) India
    pateljuhi63@yahoo.com

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