Articles

ABOUT AUTHOR:
Amitava Sinharay
B.Pharm
India
a.amitava.s@gmail.com

ABOUT AUTHOR:
Arya K.R.
Department of Pharmaceutics, Regional Institute of Medical Sciences and Research,
MG University, Kottayam
aryajithu@yahoo.com

ABOUT AUTHORS:
Sandeep Kumar Patro*, M.Jhansi, Dr.A.M.S.Sudhakar Babu, Sk.Asief, P.Ramesh Babu
A.M.Reddy memorial college of pharmacy, Narasaraopet.
Sandeepkumarpatro2@gmail.com

ABSTRACT
Study of drug - excipient compatibility is an important process in development stage of dosage forms. Incompatibility between drugs and excipients alter drug stability and bioavailability &there by affect their safety and efficacy. Dosage form is a pharmaceutical drug delivery system, which is a combination of drug(s) and non-drug  components called as excipients. Drug is a chemical substance obtained from either natural, synthetic or semi synthetic source, which is used for the treatment, curing, prevention  or mitigation of a disease or disorder in human beings or animals Excipients are nondrug components which are serve specific purposes like shape, stability, solubility, elegance, palatability etc. of a dosage form. These are also called as adjuvants, additives or pharmaceutical aids. The evaluation of drug-excipient compatibility is therefore an essential aspect of any preformulation study. To evaluate the drug- excipient compatibility different techniques such as  Thermal analysis, Differential scanning  calorimetric (DSC) study, Infra red spectrophotometric study (IR), Isothermal stress testing (IST), High performance liquid chromatography (HPLC),Thin layer chromatography (TLC), Solution calorimetry  were adopted.

About Authors:
N.V. Sateesh Madhav, Abhijeet Ojha, Pallavi Uniyal, Dheeraj Fulara*
DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
Uttarakhand, India.
*fularadheerajmpharm@yahoo.com

About Authors:
Enegide Chinedu*, David Arome, SolomonF. Ameh
Department of Science Laboratory Technology (Physiology & Pharmacology Technology),
University of Jos, Jos Nigeria.
chinex.snow@gmail.com

Abstract
Phytochemicals are referred to as pharmacologically active substances which are naturally present in plants. However, the effects of various plant preparations in the body when administered, is dependent on the phytochemicals present. Herbal medicine have been said to be the oldest form of medicine and have of recent even gained new momentum due to its advantages.The World Health Organization has recognized that traditional herbal plants may be useful in an integrated health care deliverysystem in several countries. But however to achieve the goal of using both herbal medicine and modern medicine paripassu, there is need for the phytochemical assessment of the plants coupled with pharmacological and toxicological investigations as well. Therefore, the aim of this research is to evaluate the phytochemicals present in the aqueous and ethanolic extracts of some herbal plants in Jos, Nigeria. This study have unveiled the presence of various phytochemcals in the different plant extracts examined. The various phytochemicals present in the extracts includes alkaloids, saponins, tanins, flavonoids, carbohydrates, steroids, cardiac glycosides and anthraquinones. These phytochemicals are known to posses therapeutic and also physiological activity. The test have shown that the plants are useful as they contain phytochemicals capable of producing valuable pharmacological effects. However, further studies aimed at establishing the dosage in which the may produce their pharmacological effects and toxicity should be done. Studies aimed at isolating the phytochemicals and screening their individual effects will also be very useful.