PharmaTutor (December- 2013)
ISSN: 2347 - 7881
Received On: 29/10/2013; Accepted On: 03/11/2013; Published On: 20/12/2013
Authors: Edukondalu Vanka, M. Jhansi Rani, A.M.SudhakarBabu, P.VenkatesawaraRao
Department Of Pharmaceutics,
A.M. Reddy Memorial College of Pharmacy,
Narasaraopet, Guntur (district), Andhra Pradesh
ABSTRACT: Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery System. Among them Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. The drug delivery is designed according to the circadian rhythm of body. System is suit for the drugs which shows high first pass effect. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like Time controlled pulsatile release systems, Stimuli-induced pulsatile release system, Externally regulated pulsatile release system, multiparticulate regulated pulsatile release system have been dealt with in the article. This delivery occurs at predetermined lag time. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arrhythmic and antiasthmatic.
How to cite this article: Vanka E., Rani MJ, Babu AMS, Rao PV, An Overview on Pulsatile Drug Delivery System, PharmaTutor, 2013, 1(2), 17-22
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