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  • 21 February 2014

    INTERLEUKINS IN THERAPEUTICS

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    ABOUT AUTHOR:
    Anjan Khadka
    Department of Pharmacology,
    AFMC, Pune, India
    anjankhadka14@yahoo.com

    ABSTRACT:
    Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour. On the basis of their respective cytokine profiles, responses to chemokines, and interactions with other cells, these T-cell subsets can promote different types of inflammatory responses. During the development of allergic disease, effector TH2 cells produce IL-4, IL-5, IL-9, and IL-32.  IL-25, IL- 31, and IL-33 contributes to TH2 responses and inflammation. These cytokines have roles in production of allergen-specific IgE, eosinophilia, and mucus. ILs have role in therapeutics as well as diagnosis and prognosis as biomarker in various conditions. Therapeutic targeting of the IL considered to be rational treatment strategy and promising biologic therapy.

  • 20 February 2014
    A REVIEW ON INTERSTITIAL CYSTITIS SYNDROME (ICS)

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    About Authors:
    M Sushma*, TVV Vidyadhar, R Mohanraj, M Babu
    Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education & Research (RIPER),
    K R Palli Cross, Near S.K University, Anantapuramu District, Andhra Pradesh, INDIA.
    *sushma.banthi@gmail.com

    Abstract:
    Interstitial cystitis (IC) is an irritative bladder syndrome of multifactorial aetiology and is said to be one of the several conditions that causes bladder pain, which is most commonly seen in women than in men. It is of unknown aetiology. But some factors like autoimmune disorder, Genetic predisposition, Gynaecologic surgery in the past, History of recurrent UTIs. The body's immune system attacks the bladder, similar to other autoimmune conditions. The urologist may use a special scope called a cytoscope to look inside your bladder for inflammation, pinpoint bleeding. Management of IC is done by oral therapy of pentosanpolysulphate, Tricyclic anti-depressants, Anti-histamines, Non-steroidal anti-inflammatory drugs, Bladder analgesics. Whereas intravesical therapy Dimethyl sulphoxide, heparin, Bacillus calmette-Guerin

  • 18 February 2014
    A REVIEW: ATHEROSCLEROSIS & ITS TREATMENT

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    About Author:
    Mr. Yogesh K. Patil
    Lecturer, Department of Pharmacology,
    Shree Mahavir Institute of Pharmacy,
    Nashik.
    yogesh_kpatil85@yahoo.co.in

    Abstract:
    Atherosclerosis is deposition of fatty substances into the inner wall of blood vessels. Due to deposition of lipid material into blood vessels there is restricted flow to blood to various organs like kidney, heart, lungs etc. To overcome this effect various drugs available in market like statins, fibrates etc. There is also way to clean lipid from inner lining of blood vessels through surgery which is last step of treatment. There are mainly two surgeries available that is bypass surgery of heart and angioplasty.

  • 17 February 2014
    VALUE BASED PRICING-NEW CONCEPT

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    About Author:
    Shwetlata Singh
    Pharmaceutical Management
    Delhi Institute of Pharmaceutical Sciences & Research, Delhi
    shweta.kul99@yahoo.com

    Abstract:
    This article involves discovering how Value-Based Pricing(VBP) is creating a buzz in pharmaceutical sector. The goal is to make people understand what is exactly VBP. It will give valuable information regarding various pricing policies in pharma & pros & cons of VBP. Article also includes brief  implication of this policy in UK health sector where this policy has been applied recently.

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  • 16 February 2014
    ANTI-DIABETIC ACTIVITY OF GOSSYPIUM HERBACEUM BY ALLOXAN INDUCED MODEL IN RATS

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  • 13 February 2014
    PROBIOTICS - A REVIEW

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    About Authors:
    V.Sankar1*, Akash kurian2
    *1Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore.
    2PHARM.D Intern, PSG College of Pharmcy, Coimbatore.
    *akash.kurian8@gmail.com

    Abstract:
    The objective of review is to outline the probiotics use in medicine and to give insight in to the field for different applications. The use of probiotics in treatment regimen is increasing. Probiotics are live organisms and prebiotics are components of food that are not otherwise easily digested by humans and these food components essentially feed beneficial bacteria in the gut. Probiotics can be formulated to many different types of products including drugs, foods and dietary supplements. Species of lactobacillus and bifidobacterium are most commonly used as probiotics. Probiotics are intended to assist the body’s naturally occurring gut mitochondria. Some probiotic preparations have been used to prevent diarrhea caused by antibiotics or as part of treatment for antibiotic related dysbiosis. This article focus on the probiotics use,  clinical trials and its future.

  • 10 February 2014
    ENHANCEMENT OF SOLUBILITY CHARACTERISTICS OF ALPRAZOLAM

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  • 9 February 2014
    A REVIEW: EFFECT OF DIABETES ON VASCULAR ENDOTHELIUM

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    About Authors:
    Yogesh K. Patil
    Lecturer, Department of Pharmacology,
    Shree Mahavir Institute of Pharmacy,
    Nashik.
    yogesh_kpatil85@yahoo.co.in

    Abstract:
    Endothelial dysfunction is mainly observed in diabetics. The main role of endothelium is to control the tone of the vascular smooth muscle through the production of vasodilator mediators like nitric oxide (NO), prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF). Impaired endothelium-dependent vasodilation has been observed in vascular beds of different animal models of diabetes and in humans with type 1 and 2 diabetes. Hyperglycaemia causes repeated acute changes in intracellular metabolism and causes activation of polyol pathway, activation of protein kinase C, advanced glycation end product and increased oxidative stress.

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  • 7 February 2014
    REVIEW: AN OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

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    About Authors:
    Hemant Maheta, MR Patel, KR Patel, MS Patel
    Department of Pharmaceutics,
    Shri B.M.Shah College of Pharmaceutical Education and Research,
    College Campus, Modasa-383315, Gujarat, India.
    hsmehta19@gmail.com

    Abstract:
    The purpose of writing this review on floating drug delivery systems was special focus on the principle mechanism of floatation to achieve gastric retention. Conventional oral dosage forms has short residence times & unpredictable gastric emptying time. The idea of gastric retention comes from the need to localize drugs at a specific region of gastrointestinal tract (GIT) such as stomach in the body. Many drugs get absorbed only in the upper intestinal tract, designing such molecules as once-daily formulations are exclusive for these molecules. Thus GI retention platforms had emerged. Gastroretentive drug delivery systems are designed to be retained in the stomach for a prolonged time. Gastroretentive drug delivery systems have potential for use as controlled release drug delivery system. The use of floating drug delivery system is one method to achieve prolonged gastric residence times, providing opportunity for both local & systemic drug action. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. This article aims at reviewing the floating drug delivery system including types, approaches for designing the floating dosage form, advantages & disadvantages of FDDS.

  • 6 February 2014
    A CRITICAL INSIGHT INTO THE INTRICATE ROLE OF PLANT HORMONES IN GROWTH AND DEVELOPMENT PHASE

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    About Authors:
    Puneet Sudan*, Swati Sudan, Tapan Behl, Monika Sharma, Rashi Wanchoo Misri
    Department of Pharmacognosy,
    Doaba College of Pharmacy, Kharar, Punjab
    *puneetsudan22@gmail.com

    Abstract:
    Plant hormones are specialized and very vital chemical substances produced by plants. The chemicals are each grouped together into one of these classes based on their structural similarities and on their effects on plant physiology. Plant stress hormones activate cellular responses, including cell death, to diverse stress situations in plants.

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