Articles

About Authors:
Sukanto Paul, Krishan R Bhadu
Department of Quality Assurance, School of Pharmaceutical Sciences,
Jaipur National University,
Jagatpura, Jaipur-302025,
Rajasthan, India.

ABSTRACT
A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Tirofiban hydrochloride in pure and marketed formulation. Chromatography was carried out on a BDS Hypersil C18 (4.6 mm × 250 mm, 5 μm) using Buffer: Acetonitrile in the ratio of 80:20 (v/v) as the mobile phase at a flow rate of 1.5 mL/min and eluents were monitored at 274 nm using UV detector at ambient temperature.  The average retention time of Tirofiban was found to be 9.124 min. The method was validated for linearity, precision, accuracy, specificity, robustness and solution stability. The calibration curve was linear (R²≥0.9999) over the range of 12.5-75 μg/mL.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.11 μg/mL and 0.33 μg/mL respectively. This method can be successfully employed for the quantitative analysis of Tirofiban hydrochloride in bulk drugs and formulations.

About Authors:
Garg Pushpendra, Nanda Arun
Department of Pharmaceutical Sciences
Maharshi Dayanand University, Rohtak-124001
Haryana, India.

ABSTRACT
The objective of the present study was to improve the dissolution rate of gliclazide, a poorly water soluble (BCS class-II) drug by solid dispersion technique using a water soluble carrier, poloxamer 407. The solid dispersions were prepared by fusion method using different concentrations of carrier and the prepared systems showed an enhancement in dissolution. Solid dispersions were characterized with Differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and dissolution analysis. The study revealed that enhanced dissolution of gliclazide from solid dispersion was due to a decrease in crystallinity of drug and also due to dissolution of gliclazide in molten form of solid dispersion. In conclusion preparation of gliclazide dispersion with meltable hydrophilic polymer could be a promising approach to improve the dissolution rate.

About Author: G. Anand Rao*, V. Venu, R. Senthil Selvi, P. Perumal,
Department of Pharmaceutics,
J. K. K. Nattraja College of Pharmacy,
Komarapalayam - 638 183, Namakkal (D.T),
Tamil Nadu, India

Abstract
The main objective of the present work was to develop sustained release matrix tablets of Lornoxicam using Hydrophilic polymers viz. Hydroxy propyl methyl cellulose (HPMC K4M, HPMC K10M, HPMC K15M) was developed using wet granulation technique at varying ratios of drug and polymer like 1:1, 1:2 and 1:3 were selected for the study. Micro crystalline cellulose and Lactose was added in this formulation as a function of binder and diluent. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N Hcl, pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analyzed by Korsmeyer- Peppas law expression. It was observed that matrix tablets contained polymer HPMC K10M was successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation F9 which contains 1:3 ratios of drug and polymer release the drug which follows Zero order kinetics via, swelling, diffusion and erosion. Stability studies (40±2oc/75±5%RH) for three months indicated that Lornoxicam was stable in the matrix tablets. The FTIR study revealed that there was no chemical interaction between drug and excipients.

About Author: Manoj Dupati, Shiva Kumar, Sharadamma K. C. and Radhakrishna P. M.
Provimi Animal Nutrition India Pvt Limited,
Yelahanka New Town, Bangalore – 560 106,
Karnataka, India

Plants have provided human beings for all needs in terms of shelter, clothing, food, ?avours and medicines. In particular plants have formed the basis of sophisticated traditional medicine systems like Ayurvedic, Unani, and Chinese amongst others. These systems of medicine have given rise to some important drugs which are being used in modern medicine too. This article highlights and provides an overview of the classes of molecules present in plants having specific biological activity and finds use as feed additives ensuring better health and productivity of live stock.

[adsense:336x280:8701650588]

This article is about Biotech courses, scholarships and institutes for students specially universities which offer Post Graduate degrees in research in Bio-technology. Article also looks at the specialization offered by the universities along with the total number of seats.

University Of Allahabad
Total Number of Seats - 12 seats

About Author: Patil Amol Vilas,* Madgulkar Ashwini R., Bhingare Chandrashekhar L., Bhalekar Mangesh R., Jamadar Shahaji Ambadas
Department of Pharmaceutics,
AISSMS College of Pharmacy,
Kennedy Road, Near R.T.O.,
Pune - 411 001, INDIA

Abstract
Pellets are of great interest to the pharmaceutical industry for a variety of reasons. Pelletized products not only offer flexibility in dosage form design and development, but are also utilized to improve safety and efficacy of bioactive agents. However, the single most important factor responsible for the proliferation of pelletized products is the popularity of controlled release technology in the delivery of drugs. This research article mainly focused on the Surface Morphology and Drug Release Studies on Repaglinide Controlled Release Pellets Prepared by Solution layering method with Blend of PEG - HPMC - EC Polymersof controlled release pellets of Repaglinide. Surface morphology study to revel morphological changes when pellets were exposed to dissolution study and correlate their relation from P1 to P9 batches. Amongst all batches, P1 batch selected for morphological evaluation by using Scanning Electron Microscopy (SEM). XRD study done for powder characterization of drug before and after manufacturing process. Cellulose derivative blend of Hydroxypropyl methylcellulose (HPMC-K100), Ethyl cellulose (EC) and PEG4000, due to their hydrophilic and hydrophobic properties and ease of application provide desired drug release profile Upto 12 Hrs, when used in optimum concentration P1 batch (1:1%).

About Author: 1) Pankaj H. Chaudhary, M.Pharm
Dept. of Pharmacognosy, Government College of Pharmacy,
Kathora Naka, Amravati – 444604, Maharashtra, INDIA.
2) Somshekhar S. Khadabadi*. M.Pharm., PhD.
Dept. of Pharmacognosy, Government College of Pharmacy,
Kathora Naka, Amravati – 444604, Maharashtra, INDIA.

Abstract
In the present study, the aphrodisiac activity of Bombax ceiba Linn. (Bombacaceae) root extract was investigated. The extract (400 mg/kg body wt./day) was administered orally by gavage for 28 days. Mount latency (ML), intromission latency (IL), ejaculation latency (EL), mounting frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and post-ejaculatory interval (PEI) were the parameters observed before and during the sexual behavior study at day 0, 7, 14, 21, and 28. The extract reduced significantly ML, IL, EL and PEI (p < 0.05). The extract also increased significantly MF, IF and EF (p < 0.05). These effects were observed in sexually active and inactive male mice.

About Author: Dhaval G. Shah^*, Dr Manish J. Patel, Dr Laxman J. Patel
Department Of Pharmaceutical Chemistry,
Shree S. K. Patel College Of Pharmaceutical Education & Research,
Ganpat University, Kherva. Dist: Mahesana, Gujarat

Abatract
Human Immunodeficiency Virus is the causative agent of Acquired Immuno Deficiency Syndrome (AIDS), a disease which has claimed twenty millions lives worldwide in the last two decades. Recently Imidazole derivatives, such as N-aminoimidazoles (NAIMS) have been discovered as novel anti- HIV agents. Herein, the results of 2D-QSAR analysis on these inhibitors have been reported. Quantitative Structure Activity Relationship studies have been conducted on a series (25 compounds) of NAIMS with selective HIV inhibition activity using ChemOffice v.8.0 software. The best prediction have been obtained for anti-HIV activity (R²=0.82, Q²=0.73). The equation emphasized the importance of MORAN AUTOCORELATION (BY ATOMIC MASS), GAERY AUTOCORELATION (BY ATOMIC , SHAPE PROFILE(RANDIC MOLECULAR PROFILE), MAXIMAL  ELECTROTOPOLOGICAL EGATIVE VARIATION and Km parameters on biological activity. The equation is validated by test set (8 compounds). The information obtained from this 2D- QSAR may be utilized in the design of more potent NAIMS analogs and anti-HIV agents.

About Author: Devendra Kumar^1*, Durga Prasad Dash¹, Shushank Dixit², Pragya Seth³
Department of Pharmaceutical technology,
¹Sri Satya Sai collage of Pharmacy (Sehore),
²NH-58, Bagpath road bypass, MIET, Meerut,
³Laxmi Narayan College of Pharmacy, Bhopal

Abstract
This study has been undertaken to investigate the effect of methanolic extract of almond nuts of Prunus amygdalus (batsch.) on pylorus ligation gastric ulcers in Wistar rats. Treatment with Prunus amygdalus extract of (200 mg/Kg bodyweight, 400 mg /Kg body weight) and ranitidine (50 mg/ Kg body weight) for 1 hr to the Ethanol and  rats Pylorus ligation were given and absorb the acid parameters. The present study provides a strong evidence of antiulcer activity of Prunus amygdalus extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters (i.e. total and free acid), gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier. Administration of Prunus amygdalus (200 mg/kg & 400mg/kg p.o.) increased CAT, and GSH levels as compared to the negative control group, which suggests its efficacy in preventing free radical-induced damage. However, significant increase was observed all doses but in 400mg/kg were better results. In this present study was showed that there was present a significant protection for Hexosamine in all treated groups in compare to negative control group. The LPO results in showed that there was significance level difference present in negative control group and all other group that indicated that lipid peroxides enzyme was higher in vehicle treated group. Ulcer score is the counting of spots and severity of damage in gastric part by any moiety such as ethanol. Single drug treatment (200 mg/kg and 400mg/kg of P.A.E.) was effective up to a significant level (P<0.05) in compare to negative control group. Volume of gastric juice indicate the secretions of gastric fluid and it is higher in negative control group and all drug treated group was effective in relation to negative control group (P <0.05).

[adsense:336x280:8701650588]