Synthesis and evaluation of carbodithioic acid esters of naphthylmethylamine, a novel class of spermicides

About Authors
M. M. Singhal, Monica Gupta
Department of chemistry,
Delhi Institute of Pharmaceutical science & Research,
New Delhi, India

Affiliation Affiliated from Govt. of NCT Delhi

Abstract :
Carbodithioic acid esters of naphthylmethylamine prepared by replacing the amino function in amino methyl side chain with carbodithioic acid ester group and by adding various S-2-hydroxy propyl ester of dialkyl carbodithioic acid at amino group. Some of these compounds showed better spermicidal activity. The study revealed that incorporation of carbodithioic acid residue directly into naphthylmethylamine leads to compounds with better spermicidal activity and naphathalene-1-yl-methyl-carbodithioic acid-3-dialkyl amino-2-hydroxy-propyl ester has shown better profile than nonoxynol-9. Further, lead optimization may yield a potent spermicide.


About Authors:
Ankit Kumar Jhangta,
Kumaun Univ. Nainital

Mobile telecommunication technology became commercially available about 20-30 year ago in different countries around the world commencing with europian countries. Telecommunication Industry has grown by leaps and bound over the last decade. Thus any health hazard from these devices promises  to have large
epidemiological impact as more than half of the population are mobile users.The key aim of this paper is to scientifically and objectively review data suggesting or refuting a relationship between mobile phone usage and brain tumours.

Eclipta alba (L.) A review on its phytochemical and pharmacological profile

About Authors:
Mithun NM*, Dr.Shashidhara S1

Dept. of Pharmacognosy,
Government college of pharmacy,

Abstract: Eclipta alba (L.) is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. Recent studies showed an antivenom property & corrosion pickling inhibitor action on mild steel in hydrochloric acid. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. This contribution provides an comprehensive review on ethnomedicinal uses, chemical composition, and the pharmacological profile as medicinal plant. Particular attention is given to antihepatotoxic, analgesic, antioxidant , antihyperglycemic, antiaggresive, wound healing properties and insecticidal effects presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.

Hypoglycemic effect of wheatgrass juice in Alloxan induced diabetic rats

About Authors:
M. R. N. Shaikh, Majaz Quazi, Dr. R. Y. Nandedkar
A. R. A. College of Pharmacy,
Dhule – 06.


Wheatgrass has many characteristics desirable for health. It is known for its healing property. It is used as a cleansing and purifying agent and yet can be considered as a bodybuilder because of its nutritional value. It contains about 70% of chlorophyll which is very much comparable to alfalfa plant. Due to its high chlorophyll content it is also referred as Green Blood. Wheatgrass contain number of amino acids, vitamins, enzymes which contribute significantly to its health benefits. This article is nothing but an attempt to highlight one of the benefits of wheatgrass. The present investigation is undertaken in order to evaluate hypoglycemic property of wheatgrass juice.