Overview and Information of BENFOTIAMINE

About Author: Sayani Chakrabarti
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia

Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has potential anti oxidant effect. A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.


About Authors: Ms.Komal  R. Nikam (B.Pharmacy), Mr.Mahendra G. Pawar (B.Pharmacy), Mr. Kishor S. Salunkhe (M.Pharm,PhD), Mr.Devidas G.Bachhav(M.Pharm)
Amrutvahini college of pharmacy,Sangamner.(Pune University)

The demand for novel drug delivery technologies is ever increasing. These drug delivery technologies includes oral, transdermal, inhalation and parenteral. The main goal for the delivery of any drug therapy is oral administration with once or twice daily dosing. However, there are large numbers of therapies, particularly protein-based, gene-based vaccine-based that cannot be delivered by this route for example insulin, growth hormones and other similar biologicals.
The pitfalls of needle-based injections are well known. Psychological resistances to self-injection or needle-phobia have been documented across large demographic groups, such as diabetics. The result of this phobia is that many outpatient injectables are dosed sub-optimally. Furthermore, awareness of serious problems has caused physicians and their patients to either delay therapy initiation or seek out less-invasive alternatives, even at some cost to clinical effectiveness.
For some, especially those suffering from chronic diseases requiring injectable products two or three times a day, this process is an ongoing reality of daily life for example diabetics-accepted, but always with the hope that something new will replace the ritual of needle insertion. To overcome the problems related to needle based injections, there is one technology that has received considerable attention during the past few years and that offers all of the sought after benefits is—Needle Free Injection Technology (NFIT).

Lawsonia inermis - From traditional use to scientific assessment

About Authors: Inder Kumar Makhija
Department of Pharmacognosy,
Manipal College of Pharmaceutical Sciences,
Manipal University, Manipal-576 104,

The world is endowed with a rich heritage of medicinal plants. The use of medicinal agents presumably predates the earliest recorded history. Medicinal plants are widely used by traditional practitioners for various ailments. Lawsonia inermis (Lythraceae) commonly known as ‘Henna’is a well-known plant used in the Indian medicine. Various parts of this plant have been used in traditional Indian medicine. The plant has wide range of phytochemicals including lawsone, isoplumbagin lawsoniaside, lalioside, lawsoniaside B, syringinoside, daphneside, daphnorin, agrimonolide 6-O-β-D-glucopyranoside, (+)-syringaresinol O-β-D-glucopyranoside, (+)-pinoresinol di-O-β-D-glucopyranoside, syringaresinol di-O-β-D-glucopyranoside,  isoscutellarin3β, hennadiol, (20S)-3β, 30-dihydroxylupane, lawnermis acid, 3-methyl-nonacosan-1-ol, laxanthones I, II, III and lacoumarin etc. The various in-vitro and in-vivo studies of L. inermis reported the plant to have antibacterial, antifungal, antiparasitic, antiviral, anticancer, antidiabetic, tuberculostatic, anti-inflammatory, antifertility and wound healing properties. This review discusses on the botany, traditional use, phytochemistry and pharmacological data of the plant.

Stress Induced Method Development and Validation of Olmesartan in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method

About Authors: 1Arun Kumar Dash*, 2Amitesh Palo,
1. Royal College of Pharmacy and Health Sciences, Berhampur.
2. College of Pharmaceutical Sciences, Mohuda, Berhampur

A simple method for the estimation of Olmesartan in bulk and pharmaceutical dosage forms has been developed. Methanol was chosen as the solvent system. The λmax was found to be 257nm and all absorbance values were carried out at 257nm. The responses were linear in the range of 5-35µg/ml. The regression equation of the calibration graph and correlation coefficient were found to be y = 0.049x + 0.007 and 0.999 respectively. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 99.36 and 100.49%. The proposed method was validated for precision, accuracy, intraday, interday assay, robustness and ruggedness. Commercial tablets containing 20mg and 40mg of Olmesartan were analyzed by the proposed method and the results were well within the claimed limits. Furthermore stability studies of Olmesartan were carried out under acidic, alkaline, hydrolytic and photolytic conditions as per SIAM (Stability Indicating Assay Methods).

Synthesis and biological evaluation of newer analogues of 2,5-disubstituted 1,3,4-oxadiazole as antioxidant and anticonvulsant agents

About Authors: Arun Dureja*, Kalpana Divekar and M.S.Sandhyavali
Department of Pharmaceutical Chemistry,
Dayananda Sagar College of Pharmacy,
Kumaraswamy Layout,

A series of 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives were synthesized and evaluated for their anticonvulsant and antioxidant activities. Initially Ethyl-2-oxo-2H-chromene-3-carboxylate was prepared by reacting Salicylaldehyde with Diethyl malonate in presence of piperidine. This compound was treated with hydrazine hydrate to give aromatic hydrazides. Those hydrazides were refluxed with different aldehydes to form arylidines, which were then treated with acetic anhydride to form 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives. The structures of synthesized compounds were characterized and confirmed by IR and 1HNMR and then screened for antioxidant activity by DPPH reduction method and anticonvulsant activity by MES method. The investigation revealed that out of eight newly synthesized derivatives five were found to possess significant anticonvulsant activity but none of the derivative was found with antioxidant activity.


About Authors: Deepak Sahu
M.Pharm, Geetanjali Institute of Pharmacy
Udaipur, Rajasthan

A simple, accurate, low cost and specific HPTLC method for estimation of quetiapine fumarate in tablet has been developed. It was performed on Silica gel G60 F254 aluminium foil using acetonitrile : chloroform in the ratio of 1:9 as mobile phase. The mobile phase having chamber was saturated for 20 minutes at room temperature. The Rf value of quetiapine fumarate was found to be 0.45. The plate was scanned and quantified at 242 nm. The calibration curve response was observed between 5-25 μg. The linear regression data showed good linear relationship of r = 0.999. The percent recovery was found to be 100.0 ± 0.01.The developed method was validated for its accuracy and precision with suitable parameters.


About Author
Sayani Chakrabarati,
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia

In pharmaceutical industries, many unprecedented challenges have to be faced regarding cost, time, labour, tough competition by other companies etc. To overcome these problems & curve a significant niche in global market, a new approach has been brought named lean sigma. This concept is used to make work BETTER & FASTER. Many companies have embarked on major improvement programs, including internal re-organization, greater externalization to embrace the biotech culture & capture innovation, & the movement of investments to lower cost countries. The Lean Sigma is a very positive approach in such third-world countries like India. This approach will help to beat the recession after effects very soon with appreciable efficiency.


About Authors: NEHA BATRA, S K Dubey

Ageing or aging is the accumulation of changes in an organism or object over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social changes, the things you do this year can halt and even reverse many of health and cognitive issues faced by those over age 50. You could be in better shape, have fewer aches and pains AND have more energy than you did 10 years ago. Anti aging is possible. The body requires two vital materials- energy and raw material for anti-aging. There are many food and herbal treatment available in market for anti aging.


About Authors: HONEY JAIN, Mr Ranjan Bairwa

Even with improvements in health care, many Boomers are finding themselves overwhelmed with the stresses of modern life. Luckily, there are natural ways to relieve stress, including daily exercise, meditation, deep-breathing techniques and the use of time-honored herbal supplements.‘Stress response’ are many and varied-marriage, divorce, death of a loved one, new job, move, etc.-any intense emotion such as fear or anger, fatigue, physical injury, surgery, temperature extremes, noise, crowding, illness.
There is a definite relationship between stress and illness, although the exact nature of this relationship is not yet fully understood. The more frequent and severe the life changes, the more likely we are to become ill.Combination of key traditional anti-stress herbs may help settle down your world and step up your energy levels to dynamic new heights.