Articles

About Authors:
Anil kumar
Jubilant chemsys Limited, Noida-201301
Babu Banarsi Das National Institute of Technology and Management
Akhilash Das Nagar, Lucknow

Abstract
Presence of moisture influences chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability in solid dosage forms and lead to growth of microorganisms, change in thixotropy in semi-solid dosage forms. Moreover, unit operations obviously depending on the amount and state of water present are also influenced by it. Therefore, moisture influences the properties of individual active ingredients and excipients, and it is essential to characterize the effect of moisture on these individual components. This article lay emphasis on determination of moisture by various methods and illustrates the changes induced by moisture on several product and process attributes

About Authors:
Kaushal Chovatiya, D.R. Mundhada
Agnihotri College of Pharmacy, Wardha,
Maharashtra, India.

Abstract:
Cancer is the second leading cause of death worldwide. Conventional cancer therapies cause serious side effects and, at best, merely extend the patient’s lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. The demand to utilize alternative concepts or approaches to the treatment of cancer is therefore escalating. There is compelling evidence from epidemiological and experimental studies that highlight the importance of compounds derived from plants “phytochemicals” to reduce the risk of colon cancer and inhibit the development and spread of tumors in experimental animals. More than 25% of drugs used during the last 20 years are directly derived from plants, while the other 25% are chemically altered natural products. Still, only 5-15% of the approximately 250,000 higher plants have ever been investigated for bioactive compounds. The advantage of using such compounds for cancer treatment is their relatively non-toxic nature and availability in an ingestive form. An ideal phytochemical is one that possesses anti-tumor properties with minimal toxicity and has a defined mechanism of action. As compounds that target specific signaling pathways are identified, researchers can envisage novel therapeutic approaches as well as a better understanding of the pathways involved in disease progression. Plant derived compounds have played an important role in the development of several clinically useful anticancer agents. Several anticancer agents including taxol, vinblastine, vincristine and topotecan are in clinical use all over the world. A number of promising agents such as combrestatin, betulinic acid and silvesterol are in clinical or preclinical development.An attempt has been made to review some medicinal plants used for the prevention and treatment of cancer and recent state of development of anticancer drugs regarding Natural Products.

About Authors:
Ali K. Akhtar, Waquar A. Khan,Lubna azmi
Faculty of Pharmacy,
Integral University Lucknow,
India

Abstact:
The broad and potent activity of benzofuran has established it as one of the biological importent scaffold. This article is covered the methods of synthesis of benzofuran and its derivatives, structural activity relationship and pharmacological activities so it is an effort to highlight the importance of the benzofuran in the present context and promise they hold for the future.

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About Authors:
Vinay Mishra, Shilpi Bhargava
Advance Institute of Biotech and Paramedical Sciences,
Kanpur

Introduction:
Delivering medicine to the general circulation through the skin is seen as a desirable alternative to taking it by mouth. Patientsoften forget to take their medicine, and even the most faithfullycompliant get tired of swallowing pills, especially if theymust take several each day. Additionally, bypassing the gastrointestinal(GI) tract would obviate the GI irritation that frequently occursand avoid partial first-pass inactivation by the liver. Further,steady absorption of drug over hours or days is usually preferableto the blood level spikes and troughs produced by oral dosageforms.¹

About Authors:
PIYUSH PARASAR
SPS I.T.E.R BHUBANESWAR,
INDIA

INTRODUCTION- 
CANCER A DARKER SIDE OFLIFE LITERALLY MEANS A HOPE TO LIVE FURTHER GET DIMINISHED IN THE CASE OF CANCER. MAN HAS BEEN EXPOSED TO THE CHANGING SURROUNDING EVER SINCE HE CAME INTO EXISTENCE.IN THE PROCESS HE IS VULNERABLE TO THE NUMBER OF FATAL DISEASE AMONG WHICH CANCER IS A DREADED MALADY NEXT TO CARDIOVASCULAR  DISEASE. IT IS KNOWN TO ALL OF US THAT DEATH IS INEVITABLE BECAUSE IT IS A VICIOUS CYCLE OF THE NATURE. BUT THIS TYPE OF ESOTERIC DISEASE MAKES OUR LIVES FROM SIMPLE TO COMPLEX. SOME PEOPLE BELIEVE IN THE CONCEPT OF AS YOU SOW SOW YOU SHALL REAP ESPECIALLY IN INDIA. THESE ARE ALL SPECULATIONS OF OUR WAY OF THINKING AND THOUGHTS. IN MAJORITY OF CASES WE HAVE SEEN THAT DUE TO OUR MODERN LIFESTYLE WE GET SUFFERED FROM THESE TYPE OF DISEASE.

About Author:
E.Ashwini
Microbiologist  In  Institute Of Health Systems, Hyderabad
M.Sc Microbiology From Osmania University.

ABSTRACT
The purpose of this study was to determine the effect of some cultural conditions on the xylanase enzyme production by two Isolated Species from the industrial soiland to investigate its potential to produce xylanase utilizing tomato pomace as a substrate. Xylanase activity was detected using the Dinitrosalicylic acid assay method.
The Alkalophilic bacteria isolated from the industrial soil, secreats extra cellular xylanases when grown in liquid media supplemented with eithter rice bran, grass, corn cob, or sugar baggage as a carbon sources (which were treated with 2N NaoH for removing the cellulose from these substrates). The two bacteria belonging to the species Sporo lactobacilli and Acrobacter respectively shows the high enzyme activity at high temperatures 50 degree C and 60 degree C and high enzyme activity was found at pH 8 and pH 9 for two organisms. The extra cellular enzyme has an apparent molecular weight of 66 KD & 67KD for both the organism respectively, as determined by SDS-PAGE. The purified enzyme has two peptides and was conformed by Zymogram analysis. The species sporo lactobacilli show high enzyme activity of 4.7 U/ml and the species Acrobacter shows the enzyme activity of 7.46 U/ml.

About Authors:
Dr. Amit Gangwal,
Smriti College of Pharmaceutical Education,
Indore

Introduction
Lipitor® is the best-selling drug ever, accounting for $106 billion sales over the last decade. Two generic drug manufacturers are ready to compete starting December 1, 2011. Watson Pharmaceuticals is making a generic version authorized by Pfizer under a profit-sharing agreement. Pending federal approval, Ranbaxy Laboratories also plans to sell a generic version. It is noteworthy that when a drug’s patent protection expires, the federal law permits only limited generic competition in the first six months¹.

About Authors:
Kapil Sharma¹*, Subhash Gupta ², Yogesh Sharma¹
1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
2 Oasis test house ltd.jaipur-302006,
Rajasthan, India.

SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OF SPIRONOLACTONE AND TORSEMIDE IN COMBINED TABLET DOSAGE FORM USING BY MULTICOMPONENT MODE OF ANALYSIS

ABSTRACT
A method for simultaneous estimation of torsemide (TRS) and spironolactone (SPL) in combined tablet dosage form has been developed. The method employs the application of multicomponent mode of analysis. This method utilize 50 % v/v methanol in distilled water. TRS show maximum absorbance at a wavelength of 288 nm and SPL at 238 nm. Where the linearity ranges for TRS and SPL were 1-5µg/ml and 5-25 µg/ml respectively. The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture and in market available tablet dosage form. The accuracy of the method was assessed by recovery studies and was found to be 98.15±0.64 and 100.27±0.15 for TRS and SPL respectively. Results of the analysis were validated statistically so that it can be used for routine analysis of TRS and SPL in combined tablet dosage form.

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About Auhtors:
NIDHI KARIA, RAKHI CHANDAK,
P.WADHWANI COLLEGE OF PHARMACY,
YAVATMAL

Abstract:
In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: In terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers. Similarly to ultrafine particles, nanoparticles are sized between 1 and 100 nanometers. Nanoparticles may or may not exhibit size-related properties that differ significantly from those observed in fine particles or bulk materials1. Although the size of most molecules would fit into the above outline, individual molecules are usually not referred to as nanoparticles.