Articles

STRESS HEALING THEREPY FOR BETTER LIFE

About Authors: HONEY JAIN, Mr Ranjan Bairwa
M.PHARM , PHARMACOGNOSY
JNU
JAIPUR

ABSTRACT
Even with improvements in health care, many Boomers are finding themselves overwhelmed with the stresses of modern life. Luckily, there are natural ways to relieve stress, including daily exercise, meditation, deep-breathing techniques and the use of time-honored herbal supplements.‘Stress response’ are many and varied-marriage, divorce, death of a loved one, new job, move, etc.-any intense emotion such as fear or anger, fatigue, physical injury, surgery, temperature extremes, noise, crowding, illness.
There is a definite relationship between stress and illness, although the exact nature of this relationship is not yet fully understood. The more frequent and severe the life changes, the more likely we are to become ill.Combination of key traditional anti-stress herbs may help settle down your world and step up your energy levels to dynamic new heights.

Preparation and Evaluation Antioxidant Activity of Mixed Herbal Hair Oil Formulation

About Authors: Akram Ahmad(1)*,Vikas Kumar(1) ,G.P.Mohanta(2) and Hasna Ali(2).
1-Christian school of pharmacy, FHMSIAMS (SHIATS) Allahabad (UP)-211007.
2-Department of pharmacy practice,Annamalai University,Chidambaram (T.N)-608002.

Abstract:
Antioxidants are helpful in increasing the blood circulation and thus help in hair growth as well as in the treatment a lot of diseases. Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. The Antioxidant property of plant and oil can be  utilise in hair fall .The objective of present study involves preparation of herbal hair oil using amla, brahmi, tridex, neem, shikakai and its evaluation for increase in hair growth activity. The oils with two different drug concentrations 5% & 10% were prepared using direct boiling, paste and cloth method. For determination of antioxidant activity DPPH method is used. Herbal hair oil formulation showing moderate antioxidant activity when compared with standard.it can be used as herbal hair oil for hair growth and other Free radical damage within cells has been linked to a range of disorders including cancer, arthritis, atherosclerosis, Alzheimer's disease, and diabetes.

In Vitro Dissolution Enhancement Of Felodipine

About Authors: V.P. Patel*, M.C. Gohel, R.K. Parikh
*V. P. Patel
M.Pharm, Assistant Professor, R. K. College of Pharmacy, Rajkot, Gujarat, India.
Work was carried out at: Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
M. C. Gohel
Professor and Principal, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
R. K. Parikh
Professor, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India

Abstract:
With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolution rate of felodipine poorly soluble drugs from BCS class II by complexation process. Complexation was prepared using β cyclodextrine. Different techniques were employed for preparation of complexation with β cyclodextrin like physical mixture, cogrinding, kneading technology, solvent coevaporation.The physical properties of the prepared solid mass of felodipine was characterized by in vitro dissolution studies, UV- spectroscopy, Fourior transform infrared spectroscopy, differential scanning calorimetry (DSC) and  X-ray powder differaction spectroscopy. Additionaly, phase solubility studies were performed to support the in vitro dissolution study. The results of Fourior transform infrared spectroscopy shows the compatibility of drug with cyclodextrin, while differential scanning calorimetry (DSC) and X-ray powder differaction spectroscopy showed the confirmation of complexation of β cyclodextrin with felodipine.

Tissue Culture of Endangered Brahmi (Bacopa monnieri) (Linn) family Scrophulariaceae

About Authors: - Tiwari1 Bhrigu Narayan*, Mr. Khatri1 Pankaj, Dr. Ali2 Julfikar.
1 . Department of Pharmacognosy Gyan Vihar School of Pharmacy S.G.V. University ,Jaipur (Rajasthan)
2. Department of Biotechnology, School of Science S.G.V .University, Jaipur (Rajasthan)

Abstract
Tissue culture
(often called micropropagation) is a special type of asexual propagation where a very small piece of tissue (shoot apex, leaf section, or even an individual cell) is excised (cut-out) and placed in sterile (aseptic) culture in a test tube, petri-dish or tissue culture container containing a special culture medium.Several industries and nurseries have standardized protocols for the multiplication of ornamentals like orchids genera, carnation, roses, chrysanthemum and plantation crop like banana and cardamom..The compounds responsible for the memory enhancing effects of Bacopa monniera are triterpenoid saponins called bacosides .In the Ayurvedic Materia Medica, Bacopa has been recognized for its brain enhancement characteristics. Bacopa monnieri, a member of the Scrophulariaceae family, is a small, creeping herb with numerous branches, small oblong leaves and light purple flowers. In India and the tropics it grows naturally in wet soil, shallow water and marches. Brahmi (Bacopa monnieri) (Linn) familyScrophulariaceaeis also known as Madhyarasayana in Ayurveda as it increase mental-clarityand brain stimulating action It also possesses anti-inflammatory, analgesic, antipyretic, epilepsy, insanity, anticancer and antioxidant activities, saponins such as bacosides A, B, C and D which are the active triterpenoid principles and known as "memory chemicals".Only  a  very limited research has been  carried  out  on the plant,  under  the present study  assumes singular  significance and it is supposed to contribute a great deal to the existing literature. The present paper highlights the morphogenic response of various auxins and cytokinins on Bacopa monniera.

Role of Essential Medicines in framing National Medicine Policy – An Approach from Concept to Clinic

About Authors: Ashish Chauhan.
Department of Pharmaceutical Sciences,
Lovely Professional University,
Jalandhar, Punjab.

Abstract:
The essence of essential medicines underlies in satisfying the priority health care needs of the population. The selection of essential medicines is one of the core principles of a national medicine policy as it helps to set primacies for all the aspects of the pharmaceutical system and helps in the maintenance of a proficient healthcare system globally. Devising of essential medicines and national medicine policy is fast emerging as global concept of high relevance to the public irrespective of their nationalities. The prevalence of dreaded diseases like HIV, cancer, and a worldwide upsurge in case of malaria, tuberculosis and other infectious diseases with an addendum problem of multidrug resistance has further augmented the relevance of essential medicines and formulation of a rigid comprehensive national drug policy under the endorsement of WHO medicine strategy andimplementing the same under a complete implementation plan or master plan. This review emphasis the development and selection of essential medicines along with Indian scenario. This review also emphasis the mission, objectives, components, devising and implementation of essential medicine policy along with WHO tenets and regulations.

FORMULATION AND EVALUTION OF ENTERIC COATED PELLETS OF PANTOPRAZOLE SODIUM BY EXTRUSION AND SPHERONIZATION METHOD

About Authors:  RAJESH Z. MUJORIYA,
M.PHARM.(PHARMACEUTICS)

Assistant Professor,
sardar patel college of technology, balaghat M.P.

ABSTRACT
Pantoprazole sodium is proton pump inhibitor and used as an antiulcer agent.  The study was undertaken with an aim to formulate pantoprazole sodium enteric coated pellets.
Before going to develop the formulation a detail product literature review was carried out to know about the MUPS and type of dosage form available in market. The present study was focused to formulate delayed release capsule by MUPS Technique.
Average pellets size was determined by sieve analysis and found to be 1680-1200 microns (ASTM sieve no. 12-16). Sieve analysis was the essential step before coating. Because uniform sized pellets undergo effective coating. The result indicates a effective enteric coating and delay the drug release, with 32% acryl ezee solution, is possible. The formulation developed can further be worked on. For identifying a best formulation for delayed release pellets of pantoprazole sodium.

Chemistry of Tamsulosin HCl and Estimation of Tamsulosin HCl by high performance liquid chromatography.

About Authors: Kollu Varuni, B.pharm
Vathsalya college of pharmacy,
J.N.T.U University

Introduction:
Tamsulosin is a selective, potent and competitive a  1 – adrenoreceptor antagonist and has a greater affinity for these receptors, predominantly present in the human prostate. Literature survey reveals that several methods like HPLC,HPLC-MS and LC-MS were reported for the estimation of Tamsulosin hydrochloride in combination with other drugs as well as in biological fluids [1- 3]

Validation- An important tool of GMP

About Authors:
Karmveer Tomar
B. Pharmacy, MBA(POM)
Asst. Production Manager.

Introduction:
WHO
defines Good Manufacturing Practices (GMP) as “that part of quality assurance which ensures that products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the marketing authorization.” GMP covers all aspects of the manufacturing process:  validated critical manufacturing steps;  approved written procedures and instructions; records to show all steps of defined procedures have been taken. The guiding principle of GMP is that quality is built in to a product, and not just tested in to a product. Therefore, the assurance is that the product not only meets the final specifications, but that it has been made by the same procedures under the same conditions each and every time it is made. There are many ways this is controlled – validation is that part of GMP that ensures that facility systems, equipment, processes, and tests procedures are in control and therefore consistently produce quality product.

RESEALED ERYTHROCYTES AS DRUG CARRIERS

About Authors: Varun Raj Vemula*1, Swathi Thakkalapally2, Chaitanya Kumari Bairi3
1
DepartmentofPharmaceutical Chemistry, Vikas College of Pharmacy, Jangaon, Warangal. Affiliated to Kakatiya University.
2Department of Pharmaceutics, Care College of Pharmacy, Warangal. Affiliated to Kakatiya University.
3Department of Pharmaceutics, TallaPadmavathi College of pharmacy, Warangal. Affiliated to Kakatiya University.

Abstract:
Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.

PHARMACOVIGILANCE AN OVERVIEW

About Authors: * Ryali. Jithendra, Dinesh Kumar. Pandurangan, Bandaru. Sowjanya1, Vijayaraj Kumar. Perumal2
1Department of Biotechnology, Acharya Nagarjuna University, Guntur – 522 510, India,
*1-Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, India.
2-School of Pharmacy, University College Sadaya International,Kuala Lumpur, Malaysia.

ABSTRACT:
Pharmacovigilance is an important and integral part of clinical research. Pharmacovigilance is “defined as the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term adverse effects of medicines. This addresses what exactly is pharmacovigilance?  What do we know of its benefits and risks, challenges and the future hold for pharmacovigilance in Indian medicine. Here the main focus on the aims and role of pharmacovigilance in medicines regulation and their Partners. This article describes and discusses the National programme of pharmacovigilance and centre in India. There role in collecting the reports ADRs of medicines. Further effectiveness and risk assessments of therapies are been discussed. The important role played by health care professional, pharmaceutical industries, media, and programmes carried by WHO. Finally the conclusion describes the major challenges and achievements for the future pharmacovigilance programme.

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