Articles

About Authors:
Vinay Mishra, Shilpi Bhargava
Advance Institute of Biotech and Paramedical Sciences,
Kanpur

Introduction:
Delivering medicine to the general circulation through the skin is seen as a desirable alternative to taking it by mouth. Patientsoften forget to take their medicine, and even the most faithfullycompliant get tired of swallowing pills, especially if theymust take several each day. Additionally, bypassing the gastrointestinal(GI) tract would obviate the GI irritation that frequently occursand avoid partial first-pass inactivation by the liver. Further,steady absorption of drug over hours or days is usually preferableto the blood level spikes and troughs produced by oral dosageforms.¹

About Authors:
PIYUSH PARASAR
SPS I.T.E.R BHUBANESWAR,
INDIA

INTRODUCTION- 
CANCER A DARKER SIDE OFLIFE LITERALLY MEANS A HOPE TO LIVE FURTHER GET DIMINISHED IN THE CASE OF CANCER. MAN HAS BEEN EXPOSED TO THE CHANGING SURROUNDING EVER SINCE HE CAME INTO EXISTENCE.IN THE PROCESS HE IS VULNERABLE TO THE NUMBER OF FATAL DISEASE AMONG WHICH CANCER IS A DREADED MALADY NEXT TO CARDIOVASCULAR  DISEASE. IT IS KNOWN TO ALL OF US THAT DEATH IS INEVITABLE BECAUSE IT IS A VICIOUS CYCLE OF THE NATURE. BUT THIS TYPE OF ESOTERIC DISEASE MAKES OUR LIVES FROM SIMPLE TO COMPLEX. SOME PEOPLE BELIEVE IN THE CONCEPT OF AS YOU SOW SOW YOU SHALL REAP ESPECIALLY IN INDIA. THESE ARE ALL SPECULATIONS OF OUR WAY OF THINKING AND THOUGHTS. IN MAJORITY OF CASES WE HAVE SEEN THAT DUE TO OUR MODERN LIFESTYLE WE GET SUFFERED FROM THESE TYPE OF DISEASE.

About Author:
E.Ashwini
Microbiologist  In  Institute Of Health Systems, Hyderabad
M.Sc Microbiology From Osmania University.

ABSTRACT
The purpose of this study was to determine the effect of some cultural conditions on the xylanase enzyme production by two Isolated Species from the industrial soiland to investigate its potential to produce xylanase utilizing tomato pomace as a substrate. Xylanase activity was detected using the Dinitrosalicylic acid assay method.
The Alkalophilic bacteria isolated from the industrial soil, secreats extra cellular xylanases when grown in liquid media supplemented with eithter rice bran, grass, corn cob, or sugar baggage as a carbon sources (which were treated with 2N NaoH for removing the cellulose from these substrates). The two bacteria belonging to the species Sporo lactobacilli and Acrobacter respectively shows the high enzyme activity at high temperatures 50 degree C and 60 degree C and high enzyme activity was found at pH 8 and pH 9 for two organisms. The extra cellular enzyme has an apparent molecular weight of 66 KD & 67KD for both the organism respectively, as determined by SDS-PAGE. The purified enzyme has two peptides and was conformed by Zymogram analysis. The species sporo lactobacilli show high enzyme activity of 4.7 U/ml and the species Acrobacter shows the enzyme activity of 7.46 U/ml.

About Authors:
Dr. Amit Gangwal,
Smriti College of Pharmaceutical Education,
Indore

Introduction
Lipitor® is the best-selling drug ever, accounting for $106 billion sales over the last decade. Two generic drug manufacturers are ready to compete starting December 1, 2011. Watson Pharmaceuticals is making a generic version authorized by Pfizer under a profit-sharing agreement. Pending federal approval, Ranbaxy Laboratories also plans to sell a generic version. It is noteworthy that when a drug’s patent protection expires, the federal law permits only limited generic competition in the first six months¹.

About Authors:
Kapil Sharma¹*, Subhash Gupta ², Yogesh Sharma¹
1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
2 Oasis test house ltd.jaipur-302006,
Rajasthan, India.

SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OF SPIRONOLACTONE AND TORSEMIDE IN COMBINED TABLET DOSAGE FORM USING BY MULTICOMPONENT MODE OF ANALYSIS

ABSTRACT
A method for simultaneous estimation of torsemide (TRS) and spironolactone (SPL) in combined tablet dosage form has been developed. The method employs the application of multicomponent mode of analysis. This method utilize 50 % v/v methanol in distilled water. TRS show maximum absorbance at a wavelength of 288 nm and SPL at 238 nm. Where the linearity ranges for TRS and SPL were 1-5µg/ml and 5-25 µg/ml respectively. The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture and in market available tablet dosage form. The accuracy of the method was assessed by recovery studies and was found to be 98.15±0.64 and 100.27±0.15 for TRS and SPL respectively. Results of the analysis were validated statistically so that it can be used for routine analysis of TRS and SPL in combined tablet dosage form.

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About Auhtors:
NIDHI KARIA, RAKHI CHANDAK,
P.WADHWANI COLLEGE OF PHARMACY,
YAVATMAL

Abstract:
In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: In terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers. Similarly to ultrafine particles, nanoparticles are sized between 1 and 100 nanometers. Nanoparticles may or may not exhibit size-related properties that differ significantly from those observed in fine particles or bulk materials1. Although the size of most molecules would fit into the above outline, individual molecules are usually not referred to as nanoparticles.

About Authors:
Nimisha Paharia, Ankit Mittal, Garvita Joshi
MAHAKAL INSTITUTE OF PHARMACEUTICAL STUDIES,
UJJAIN (M.P.)

ABSTRACT
The pitfalls of needle-based injections are well known. A series of discoveries led to the development of the hypodermic needle which underwent significant changes. The first air-powered needle-free injection systems were developed during the 1940s and 1950s. Needle free delivery is done conveniently both for solids and liquids. Needle-free injection systems are typically made up of three components including an Injection device, disposable needle free syringe and air cartridge. Various needle free injectors are available in the market like Biojector, vitajet, iject, cool.click etc. These formulations are designed for better acceptability and patient convenience. They offer less pain and no needle phobia. They are ideally suited to chronic injections of varying doses of insulin, proteins and monoclonal antibodies.

About Authors: NIDHI KARIA^1*, RAKHI CHANDAK¹, ARATI  RATHI²
1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

Abstract:
Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery site. The current review  provides  a good insight on mucoadhesive polymers, the phenomenon of mucoadhesion and the factors which have the ability to affect the mucoadhesive properties of a polymer.

About Authors: NIDHI KARIA¹, RAKHI CHANDAK¹, ARATI  RATHI²
1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

INTRODUCTION:
The advent of the new drug delivery systems (oral, nasal, pulmonary, transdermal, needle-free, etc.) and the development of new biochemical compounds have resulted in a need not only for enhanced protection against such factors as moisture, light, oxygen, or mechanical forces, but also for packaging forms to play a more integral role in drug delivery. A large number of lyophilized or freeze-dried drugs, for example, are currently available, and the list is growing. Biotech drugs by their very nature are much less stable than conventional compounds and demand a different mode of delivery. In this article, we will describe in more detail several examples of delivery systems to show how packaging, with an emphasis on blister and flexible materials, is being put to the test today.