ROUTES OF QUINOXALINE NUCLEUS SYNTHESIS: A REVIEW
About Authors:
Ratnadeep V. Ghadage (M. Pharmacy)
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
South Shivaji Nagar, Sangli-416416,
Maharashtra
ABSTRACT:
Quinoxaline derivatives have emerged as an important class of benzoheterocycles because of their diverse pharmacological and biological properties, which make them privileged structures in combinatorial drug discovery libraries. Also Quinoxaline derivatives constitute useful intermediates in organic synthesis. The pharmaco-logical importance of quinoxalines and their utility as building blocks in organic synthesis have directed considerable research activities toward the synthesis of suitably substituted quinoxaline rings. Extensive researches have generated numerous synthetic approaches for the construction of the skeleton of such heterocycles. Quinoxalines are, in general, comparatively easy to prepare, and numerous derivatives have been designed and prepared for potential use as biologically active materials. Oxidation of both nitrogen of the quinoxaline ring dramatically increases the diversity of certain biological properties.
Quinoxalines, including their fused-ring derivatives, display diverse pharmacological activities.A number of synthetic strategies have been developed for the preparation of substituted quinoxalines. The classical synthesis of quinoxalines involves the condensation of an aromatic 1, 2-diamine with a 1, 2-dicarbonyl compound. The reaction is facile and is the most widely used synthetic method for both quinoxaline itself and its derivatives. Despite remarkable efforts,the development of an effective method for the synthesis of quinoxalines is still an important challenge.