Articles

About Authors: 
Neha batra, honey jain
School of pharmaceutical science,
Jaipur National University, 
Jaipur

ABSTRACT
Herbal and natural products of folk medicine have been used for centuries in every culture throughout the world.Embelia ribes burm f. also known as Vidanga is one of the oldest herbs in Indian traditional medicine.This species is reported to be vulnerable in the Western Ghats of Tamil Nadu and Karnataka states of India and at a lower risk in Kerala state of peninsular India. Embelia ribes traditionally used as appetizer, carminative, laxative,  Anthelmintic  and  in liver diseases. Embelin as main consistuents of Embelia ribes having medicinal and pharmacological properties. The plant also  contains quercitol and fatty ingredients; an alkaloid christembine, a resinoid, tannins and minute quantities of a volatile oil. Embelia ribes posses many pharmacological action like analgesic, anti-fertility, antioxidant, antiandrogenic  and many more.

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About Authors:
Hardwari L. Yadav, P.K. Singour, R.S. Pawar, U. K. Patil
Department of Pharmaceutical Chemistry,
VNS Institute of Pharmacy,
Neelbud, Bhopal (M.P.)

Abstract
Chalcone are the important constituent of many natural sources and have variety of biological activities. The novel chalcone derivatives isolated from the fruits of Mallotus philippinensis called mallotophilippens. The chalcones are synthesize by claisen-schmidt base catalyzed condensation of appropriate aromatic ketones or substituted aromatic ketones with benzaldehyde or substituted benzaldehydes. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants, and have also been shown to display a diverse array of pharmacological activities. Recent reports suggest antimicrobial activity of chalcones (antibacterial and antifungal), as well as antileishmanial, antimalarial, antiviral and anti-inflammatory activities of these compounds.

About Author: Ashish Kumar Verma¹, D.Raj. Anand¹, Garima A. Tewari²
1.    Jubilant Chemsys Limited Noida 201301
2.    Babu Banarsi Das University Lucknow

ABSTRACT
Aceclofenac and paracetamol in combination are available as tablet dosage forms in the ratio of 1:5. A simple, reproducible and efficient method for the simultaneous determination of aceclofenac and paracetamol in synthetic mixture was developed. The proposed method is based on the Q-analysis UV Spectrophotometric method. The absorbance maxima of aceclofenac and paracetamol were found to be 275.4 nm and 248 nm, respectively in methanol. In Q-analysis, the isoabsorptive point for both the drugs was found at 266.1 nm. The linearity range lies between 1-35 µg/ml for aceclofenac and 1-15 µg/ml for paracetamol at their respective wavelengths. Both the drugs obey Beer’s law. The recovery studies confirmed the accuracy of the proposed methods.

About Authors:Kamal Sachdeva*², Preeti Garg¹, Manmohan Singhal², Birendra Srivastava²
1. School of Pharmacy, Suresh Gyan vihar University, Jaipur
2. School of Pharmaceutical sciences,
Jaipur National University,
Jaipur, India

Abstract: The extracts of the stem bark of Jatropha curcas (Family-Euphorbiaceae) were tested for anti-diabetic activity, using blood glucose level in normal fasted rats, glucose tolerance test. Methanol: acetone: water (70:20:10) crude extract of Jatropha curcas at the dose of 100 and 300 mg/kg had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. The extract showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Jatropha curcas stem bark possess significant anti – diabetic activity.

About Authors: Pratham Rathore ^*[1], Dhaval Patel ^[1], Vipin Rastogi ^[2]
1.  School of Pharmaceutical Sciences,
Jaipur National University, Jaipur -302025, (Rajasthan.), India
2.  Nariender Mohan hospital and heart center,
Ghaziabad, (Uttar Pradesh), India

ABSTRACT: Inpresent study,the current status of nosocomial infection, rate of infection and distribution of infectionwas analysed in patients admitted in MICU of a multispecialty hospital.Clinical data were collected from patients that presented with symptoms of nosocomial infection in MICU. We examined of 128 patients who were admitted in Nariender mohan hospital, Ghaziabad from August 2010 to May 2011. The research approach adopted in the study was a retrospective method. Incidence of nosocomial infections in M.I.C.U patients was 10.93% (14/128 patients). Urinary tract infection (42.85%) was the most frequent; followed by Lower respiratory infection (14.28%), surgical site infection (14.28%), Gastroenteritis (14.28%), Blood stream infection and Meningitis (7.14%). The nosocomial infection was seen more in the 40 to 60 year of age. The male was more prone to nosocomial infections than the female. Nosocomial infections are common in geriatric patients in the MICU setting. More studies are needed to be carried out in Indian population to plan long term strategies for prevention and management of nosocomial infections.

About Authors:
Priya Pathak, Dr.H.H.Siddiqui*, Mr T.Mehmood
Faculty of pharmacy
Integral University,Lucknow

ABSTRACT
The article is a review on all the methods which have been evolved in recent times for curbing the menace caused by arsenic to our environment and humans. Arsenic poisoning is the most spread problem these days in India,as the main reasons of arsenic poisoning include the wastes being dumped by industries which in turn helps in increasing the amount of arsenic in groundwater. Mostly used method for removal of arsenic is oxidation of As(III) to As(V) and its subsequent removal through adsorption and/or precipitation.Generally alumina is used for adsorption purpose.Many methods have also been evolved for managing the increase of arsenic amount through wastes like Cement Solidification, Dolocrete Encapsulation Technology etc.which have been discussed later in the article. Many low cost technologies are also present like Arsenic removal plant fitted directly with hand pump, Co-precipitation-Sedimentation-Filtration under continuous flow system and use of Domestic filters.These techniques are used in case when large amount of water has to be treated as rest other technologies will become quite costly in this case.Although they cannot help in removing arsenic at large level but can be used in our daily life so that we could control arsenic pollution to some extent.

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About Author:
D. J. Kalena^*, C. N. Patel
Department of Quality Assurance,
Shri Sarvajanik Pharmacy College,
Near arvind baug, Mehsana - 384 001, Gujarat, India

ABSTRACT
Combination therapy of Atorvastatin calcium (AT) and Olmesartan medoxomil (OLM) is used for the treatment of coexisting essential hypertension and hyperlipidemia in adult persons. In the present study a simple, precise, rapid, efficient and reproducible reversed?phase high performance liquid chromatography (RP?HPLC) method has been developed for the simultaneous estimation of AT and OLM present in its tablet dosage forms. Chromatographic separations were carried out isocratically at 30°C ± 0.5°C on a Kromasil C18 Column (5 μm, 250mm x 4.60mm) with a mobile phase composed of Methanol: Acetonitrile: Water (pH 3.65) in the ratio of 50:27:23 % v/v at a flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 260 nm. The retention times for AT and OLM were 5.3 ± 0.5 min and 3.4 ± 0.5 min respectively. The linearity range for AT and OLM were found to be 10?60 μg/ml and 20?120μg/ml with correlation coefficient of 0.996 and 0.999 respectively. The %recovery of the proposed method was found in the range of 98.36-100.91 for AT and 99.27-100.99 for OLM. The relative standard deviations for three replicate measurements in three concentrations of standard solution were always less than 2%. The results of the study showed that the proposed RP?HPLC method is simple, rapid, precise and accurate, which may be useful for the routine estimation of AT and OM in bulk drug and in its pharmaceutical dosage form.

About Authors:
Kapil Sharma¹*, Subhash Gupta ², Yogesh Sharma¹
1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
2 Oasis test house ltd.jaipur-302006,
Rajasthan, India.

METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF TORSEMIDE IN TABLET DOSAGE FORM BY RP-HPLC AND UV SPECTROPHOTOMETRY AND COMPARISON OF TWO DEVELOPED METHODS BY USING t-TEST

ABSTRACT
One HPLC and one UV spectrophotometric method have been developed for the determination of torsemide (TRS) in tablet dosage form. The first method is based on determinetion of TRS in tablet dosage form by RP- HPLC method.  Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 288 nm and retention time of the drug was 7.05 min.  This method produced linear responses in the concentration range 60-140  µg/ml of torsemide. The accuracy of the method was assessed by recovery studies and was found to be 99.90± 0.41 for torsemide.  The second method is based on the estimation of torsemide in tablet dosage form by UV spectrophotometry using 50% v/v methanol in distilled water.  Beer’s law obeyed over the concentration range 2-26 µg/ml at 288 nm with apparent molar absorptivity of 1.26 x 10⁴.  Both developed methods were found to be applicable for routine analysis of drug in tablet dosage form. The result of the analysis were validated statistically.The results were compared obtained from UV spectrophotometry and HPLC.

About Author:
Rajesh Mujoriya
Sardar patel college of technology,
Balaghat, dis. Balaghat,
MP–481001,INDIA

Abstract
Microspheres offer an excellent solution to creating precise pore sizes in ceramics at reasonable prices.  Polyethylene microspheres offer the added benefit of minimal residue after firing, and the availability in wide size ranges from a few micron up to 1000um (1mm).    Highly spherical microspheres have the added benefit of creating strong pores without any stress risers. Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections. Microparticulate carrier system can be administered through different routes such as i.v,ocular,i.m,oral,intra arterial.etc.Each routes has it’s own biological significance, limitation & pharmaceutical feasibility.