Articles

About Authors:
Dr. Amit Gangwal,
Smriti College of Pharmaceutical Education,
Indore

Introduction
Lipitor® is the best-selling drug ever, accounting for $106 billion sales over the last decade. Two generic drug manufacturers are ready to compete starting December 1, 2011. Watson Pharmaceuticals is making a generic version authorized by Pfizer under a profit-sharing agreement. Pending federal approval, Ranbaxy Laboratories also plans to sell a generic version. It is noteworthy that when a drug’s patent protection expires, the federal law permits only limited generic competition in the first six months¹.

About Authors:
Kapil Sharma¹*, Subhash Gupta ², Yogesh Sharma¹
1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
2 Oasis test house ltd.jaipur-302006,
Rajasthan, India.

SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OF SPIRONOLACTONE AND TORSEMIDE IN COMBINED TABLET DOSAGE FORM USING BY MULTICOMPONENT MODE OF ANALYSIS

ABSTRACT
A method for simultaneous estimation of torsemide (TRS) and spironolactone (SPL) in combined tablet dosage form has been developed. The method employs the application of multicomponent mode of analysis. This method utilize 50 % v/v methanol in distilled water. TRS show maximum absorbance at a wavelength of 288 nm and SPL at 238 nm. Where the linearity ranges for TRS and SPL were 1-5µg/ml and 5-25 µg/ml respectively. The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture and in market available tablet dosage form. The accuracy of the method was assessed by recovery studies and was found to be 98.15±0.64 and 100.27±0.15 for TRS and SPL respectively. Results of the analysis were validated statistically so that it can be used for routine analysis of TRS and SPL in combined tablet dosage form.

About Auhtors:
NIDHI KARIA, RAKHI CHANDAK,
P.WADHWANI COLLEGE OF PHARMACY,
YAVATMAL

Abstract:
In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: In terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers. Similarly to ultrafine particles, nanoparticles are sized between 1 and 100 nanometers. Nanoparticles may or may not exhibit size-related properties that differ significantly from those observed in fine particles or bulk materials1. Although the size of most molecules would fit into the above outline, individual molecules are usually not referred to as nanoparticles.

About Authors:
Nimisha Paharia, Ankit Mittal, Garvita Joshi
MAHAKAL INSTITUTE OF PHARMACEUTICAL STUDIES,
UJJAIN (M.P.)

ABSTRACT
The pitfalls of needle-based injections are well known. A series of discoveries led to the development of the hypodermic needle which underwent significant changes. The first air-powered needle-free injection systems were developed during the 1940s and 1950s. Needle free delivery is done conveniently both for solids and liquids. Needle-free injection systems are typically made up of three components including an Injection device, disposable needle free syringe and air cartridge. Various needle free injectors are available in the market like Biojector, vitajet, iject, cool.click etc. These formulations are designed for better acceptability and patient convenience. They offer less pain and no needle phobia. They are ideally suited to chronic injections of varying doses of insulin, proteins and monoclonal antibodies.

About Authors: NIDHI KARIA^1*, RAKHI CHANDAK¹, ARATI  RATHI²
1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

Abstract:
Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery site. The current review  provides  a good insight on mucoadhesive polymers, the phenomenon of mucoadhesion and the factors which have the ability to affect the mucoadhesive properties of a polymer.

About Authors: NIDHI KARIA¹, RAKHI CHANDAK¹, ARATI  RATHI²
1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

INTRODUCTION:
The advent of the new drug delivery systems (oral, nasal, pulmonary, transdermal, needle-free, etc.) and the development of new biochemical compounds have resulted in a need not only for enhanced protection against such factors as moisture, light, oxygen, or mechanical forces, but also for packaging forms to play a more integral role in drug delivery. A large number of lyophilized or freeze-dried drugs, for example, are currently available, and the list is growing. Biotech drugs by their very nature are much less stable than conventional compounds and demand a different mode of delivery. In this article, we will describe in more detail several examples of delivery systems to show how packaging, with an emphasis on blister and flexible materials, is being put to the test today.

About Authors:
Sudhir Ghawade,
Vidyabharati college of pharmacy,
Amravati

Abstract:
In recent times, focus on plant research has increased all over the world.Caesalpinia crista (Caesalpiniaceae)plant is well known for its medicinal and therapeutic values in Indian Ayurveda.The Indian traditional scriptures as well as the Ayurvedic texts have various references to the use of this plant. The bitter principles Bonducin and Natin are the primary constituent of Caesalpinia crista apart from linolic acid, fatty acid, setasitosterol and different diterpenes  which mainly believed to be responsible for its wide therapeutic action. The plant has been recommended for the treatment of various diseases and disorders such as Antispasmodic, Malarial fever, leucorrhea, abdominal pain , rheumatoid, arthritis, diabetes,cystic fibrosis,  amenorrhoea. The herb is used both, internally as well as externally. The present review attempts to provide comphrensive information on pharmacology, phytochemical study,toxicity, traditional uses and current research prospects of the herb.

About Authors:
Singh khushboo, Sharma monica,
Ram gopal college of pharmacy,
Gurgaon

ABSTRACT
Approximately 40% of new drug candidate have poor water solubility and oral delivery of such drug is frequently associated with implications of low bioavailabilty,high inter and intra subject variability, lack of dose proportionality. Bioavalibilty of lipophilic drug can be solved by formation of self emulsifying drug delivery system.SEDDS are belongs to lipid formulation and size range is from 100nm[SEDDS] less than 50nm[SMEDDS] and contain a isotropic mixture of oil, surfactant and co surfactant which are emulsified in aqueous media under condition of gentle agitation. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of emulsion in GIT with mild agitation provide by gastric motility, which present the drug in solubilized form,small size of formed droplet provided a large inter facial area for absorption,due to small globule size thAT can be easily absorb through lymphatic pathway, thereby passing hepatic pathway.

About Authors:
Prashant L. Pingale, Anjali P. Pingale  
Department of Pharmaceutics & Quality Assurance,
School of Pharmacy and Technology Management, NMIMS Shirpur Campus
Shirpur Dist: Dhule Maharashtra
INDIA 425405.

ABSTRACT:
Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.
Drug release in the human body can be measured ‘in-vivo’ by measuring the plasma or urine concentrations in the subject concerned. However, there are certain obvious impracticalities involved in employing such techniques on a routine basis. These difficulties have led to the introduction of official ‘in-vitro’ tests which are now rigorously and comprehensively defined in the respective Pharmacopoeia.
Although initially developed for oral dosage forms, the role of the dissolution test has now been extended to ‘drug release’ studies on various other forms such as topical and transdermal systems and suppositories.