Articles

FORMULATION AND EVALUTION OF ENTERIC COATED PELLETS OF PANTOPRAZOLE SODIUM BY EXTRUSION AND SPHERONIZATION METHOD

About Authors:  RAJESH Z. MUJORIYA,
M.PHARM.(PHARMACEUTICS)

Assistant Professor,
sardar patel college of technology, balaghat M.P.

ABSTRACT
Pantoprazole sodium is proton pump inhibitor and used as an antiulcer agent.  The study was undertaken with an aim to formulate pantoprazole sodium enteric coated pellets.
Before going to develop the formulation a detail product literature review was carried out to know about the MUPS and type of dosage form available in market. The present study was focused to formulate delayed release capsule by MUPS Technique.
Average pellets size was determined by sieve analysis and found to be 1680-1200 microns (ASTM sieve no. 12-16). Sieve analysis was the essential step before coating. Because uniform sized pellets undergo effective coating. The result indicates a effective enteric coating and delay the drug release, with 32% acryl ezee solution, is possible. The formulation developed can further be worked on. For identifying a best formulation for delayed release pellets of pantoprazole sodium.

Chemistry of Tamsulosin HCl and Estimation of Tamsulosin HCl by high performance liquid chromatography.

About Authors: Kollu Varuni, B.pharm
Vathsalya college of pharmacy,
J.N.T.U University

Introduction:
Tamsulosin is a selective, potent and competitive a  1 – adrenoreceptor antagonist and has a greater affinity for these receptors, predominantly present in the human prostate. Literature survey reveals that several methods like HPLC,HPLC-MS and LC-MS were reported for the estimation of Tamsulosin hydrochloride in combination with other drugs as well as in biological fluids [1- 3]

Validation- An important tool of GMP

About Authors:
Karmveer Tomar
B. Pharmacy, MBA(POM)
Asst. Production Manager.

Introduction:
WHO
defines Good Manufacturing Practices (GMP) as “that part of quality assurance which ensures that products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the marketing authorization.” GMP covers all aspects of the manufacturing process:  validated critical manufacturing steps;  approved written procedures and instructions; records to show all steps of defined procedures have been taken. The guiding principle of GMP is that quality is built in to a product, and not just tested in to a product. Therefore, the assurance is that the product not only meets the final specifications, but that it has been made by the same procedures under the same conditions each and every time it is made. There are many ways this is controlled – validation is that part of GMP that ensures that facility systems, equipment, processes, and tests procedures are in control and therefore consistently produce quality product.

RESEALED ERYTHROCYTES AS DRUG CARRIERS

About Authors: Varun Raj Vemula*1, Swathi Thakkalapally2, Chaitanya Kumari Bairi3
1
DepartmentofPharmaceutical Chemistry, Vikas College of Pharmacy, Jangaon, Warangal. Affiliated to Kakatiya University.
2Department of Pharmaceutics, Care College of Pharmacy, Warangal. Affiliated to Kakatiya University.
3Department of Pharmaceutics, TallaPadmavathi College of pharmacy, Warangal. Affiliated to Kakatiya University.

Abstract:
Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.

PHARMACOVIGILANCE AN OVERVIEW

About Authors: * Ryali. Jithendra, Dinesh Kumar. Pandurangan, Bandaru. Sowjanya1, Vijayaraj Kumar. Perumal2
1Department of Biotechnology, Acharya Nagarjuna University, Guntur – 522 510, India,
*1-Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, India.
2-School of Pharmacy, University College Sadaya International,Kuala Lumpur, Malaysia.

ABSTRACT:
Pharmacovigilance is an important and integral part of clinical research. Pharmacovigilance is “defined as the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term adverse effects of medicines. This addresses what exactly is pharmacovigilance?  What do we know of its benefits and risks, challenges and the future hold for pharmacovigilance in Indian medicine. Here the main focus on the aims and role of pharmacovigilance in medicines regulation and their Partners. This article describes and discusses the National programme of pharmacovigilance and centre in India. There role in collecting the reports ADRs of medicines. Further effectiveness and risk assessments of therapies are been discussed. The important role played by health care professional, pharmaceutical industries, media, and programmes carried by WHO. Finally the conclusion describes the major challenges and achievements for the future pharmacovigilance programme.

Synthesis and evaluation of carbodithioic acid esters of naphthylmethylamine, a novel class of spermicides

About Authors
M. M. Singhal, Monica Gupta
Department of chemistry,
Delhi Institute of Pharmaceutical science & Research,
New Delhi, India

Affiliation Affiliated from Govt. of NCT Delhi

Abstract :
Carbodithioic acid esters of naphthylmethylamine prepared by replacing the amino function in amino methyl side chain with carbodithioic acid ester group and by adding various S-2-hydroxy propyl ester of dialkyl carbodithioic acid at amino group. Some of these compounds showed better spermicidal activity. The study revealed that incorporation of carbodithioic acid residue directly into naphthylmethylamine leads to compounds with better spermicidal activity and naphathalene-1-yl-methyl-carbodithioic acid-3-dialkyl amino-2-hydroxy-propyl ester has shown better profile than nonoxynol-9. Further, lead optimization may yield a potent spermicide.

MOBILE PHONE & BRAIN TUMOUR

About Authors:
Ankit Kumar Jhangta,
M.Pharm
Kumaun Univ. Nainital

ABSTRACT
Mobile telecommunication technology became commercially available about 20-30 year ago in different countries around the world commencing with europian countries. Telecommunication Industry has grown by leaps and bound over the last decade. Thus any health hazard from these devices promises  to have large
epidemiological impact as more than half of the population are mobile users.The key aim of this paper is to scientifically and objectively review data suggesting or refuting a relationship between mobile phone usage and brain tumours.

Eclipta alba (L.) A review on its phytochemical and pharmacological profile

About Authors:
Mithun NM*, Dr.Shashidhara S1

Dept. of Pharmacognosy,
Government college of pharmacy,
Bangalore

Abstract: Eclipta alba (L.) is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. Recent studies showed an antivenom property & corrosion pickling inhibitor action on mild steel in hydrochloric acid. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. This contribution provides an comprehensive review on ethnomedicinal uses, chemical composition, and the pharmacological profile as medicinal plant. Particular attention is given to antihepatotoxic, analgesic, antioxidant , antihyperglycemic, antiaggresive, wound healing properties and insecticidal effects presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.

Hypoglycemic effect of wheatgrass juice in Alloxan induced diabetic rats

About Authors:
M. R. N. Shaikh, Majaz Quazi, Dr. R. Y. Nandedkar
A. R. A. College of Pharmacy,
Nagaon,
Dhule – 06.

 

Abstract:
Wheatgrass has many characteristics desirable for health. It is known for its healing property. It is used as a cleansing and purifying agent and yet can be considered as a bodybuilder because of its nutritional value. It contains about 70% of chlorophyll which is very much comparable to alfalfa plant. Due to its high chlorophyll content it is also referred as Green Blood. Wheatgrass contain number of amino acids, vitamins, enzymes which contribute significantly to its health benefits. This article is nothing but an attempt to highlight one of the benefits of wheatgrass. The present investigation is undertaken in order to evaluate hypoglycemic property of wheatgrass juice.

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