About Authors: Arun Dureja*, Kalpana Divekar and M.S.Sandhyavali
Department of Pharmaceutical Chemistry,
Dayananda Sagar College of Pharmacy,
A series of 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives were synthesized and evaluated for their anticonvulsant and antioxidant activities. Initially Ethyl-2-oxo-2H-chromene-3-carboxylate was prepared by reacting Salicylaldehyde with Diethyl malonate in presence of piperidine. This compound was treated with hydrazine hydrate to give aromatic hydrazides. Those hydrazides were refluxed with different aldehydes to form arylidines, which were then treated with acetic anhydride to form 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives. The structures of synthesized compounds were characterized and confirmed by IR and 1HNMR and then screened for antioxidant activity by DPPH reduction method and anticonvulsant activity by MES method. The investigation revealed that out of eight newly synthesized derivatives five were found to possess significant anticonvulsant activity but none of the derivative was found with antioxidant activity.