Articles

About Authors:
Saravana Kumar K, Ramesh Y*,  
Department of Pharmaceutics,
Seshachala College of Pharmacy,
Tirupathi – Chennai High way,  
Puttur-517 583,  Chittoor (dist),
A.P., India

Abstract
Plants and their extracts have immense potential for the management and treatment of wounds. Wound healing is complicated process that involves four phases: (i) coagulation begins immediately after injury, (ii) Inflammation which begins within hours, (iii) Proliferation which begins within days, (iv) Remodeling up to period of week, months, up to year. The phyto medicine for wound healing are not only cheap and affordable but are also purportedly safe as hypersensitive reactions are rarely encountered with the use of these agents. Mainly these crude drugs are obtained from various climatic conditions Collection, cultivating, Harvesting & Isolation of active ingredients to treat various types of diseases.

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About Authors:
Ujjwal S. Yeotkar*, Mahendra Nimbhorkar, Tushar A. Deshmukh, Vijay R. Patil
Department of Pharmacognosy,
Tapi Valley Education Society’s,
Hon’ble, Loksevak Madhukarrao Chaudhari College of Pharmacy,
North Maharashtra University,
Faizpur- 425 503,
Maharashtra, India.

ABSTRACT
Churna are important group of formulation used by Ayurvedic physicians to treat various types of diasease. Trikatu and Pimpali churna, as per Ayurvedic literature is used for the treatment of resperatory disorders. In the present study,an attempt has been made to develop a HPTLC  method of quantitative estimation of marker compound, piperine in laboratory prepared authentic formulation and a marketed formulation of Trikatu and Pimpali churna. The stationary phase used was precoated silica gel G ₆₀ F ₂₅₄ plates. The mobile phase containing n- Hexane-ethyl acetate, (5:5 v/v ), was used to separate the spot of Piperine. Plates were developed to a distance of 8 cm at room temperature. Spectrodensitometric scanning was performed by TLC scanner III (CAMAG) in absorbance mode at the wavelength of 339nm. The  R_f  values of  piperine was 0.44± 0.02. The method was validated in terms of Linearity, Accuracy and  Precision. The linearity curve found to be linear in between 200–900 ng/spot. The limit of Detection (LOD) and limit of Quantification (LOQ) were found to be  1 ng and  3 ng respectively. The mean results from % Recovery was found to be, laboratory formulation contain 85.13% and 83.47% while the commercial formulation shows 96.65%, and 90.32% respectively. The proposed method can be used to determine Piperine from Ayurvedic formulations.

About Authors:
Kapil Patel, Supriya Hazra Das
Department of Pharmacology
Shree Dhanvantary Pharmacy College,
Kim, Surat – 394118,
Gujarat, India

Abstract:  
Peptic ulcer is a condition where benign lesions of gastric or duodenal mucosa occur at a site where the mucosal epithelium is exposed to acid and pepsin, due to imbalance between offensive and defensive factors. Acacia leucophloea, a deciduous tree found throughout India is reported to be used in gastric ulcer in traditional medicine. The present study was undertaken to evaluate the anti-ulcer properties of Acacia leucophloea in pylorus ligation ulcer model in rats. Acacia leucophloea was administered for 7 days and on 8^th day 30 min prior to the induction of ulcers. Pretreatment with Acacia leaucophloea showed significant ulcer protection against pylorus ligation ulcer model as compared to control. Thus, the ulcer protective and healing effects of Acacia leucophloea may be due to its effect on both offensive and defensive factors. The present findings suggest that Acacia leucophloea has antiulcer properties.

About Authors:
V. Ravi Chandra
Research Associate
Parexel
B.Pharmacy from Priyadarshini College of pharmacy,
Osmania University,
Hyderabad, AP, INDIA

Abstract:
Huntington's disease is an intricate illness. It is a neurodegenerative, insidious disorder-which means it is harmful and fatal but gradually. The onset of the disease is very late to diagnose the disease. Huntington's disease (HD) also called as ‘Huntington’s Chorea’. Chorea means dance in Greek, which is aftereffect of genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. By choreic movement physically we can diagnose HD. HD is also a familial disease, passed from parent to child through a mutation in the normal gene. Attempts to study early disease are not unique in neurology (e.g., mild cognitive impairment and vascular cognitive impairment), but studying otherwise healthy-appearing individuals who have nearly 99% certainty of manifesting the symptoms of brain disease does provide distinct but valuable information about the true natural history of the disease. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. HD occurs in about one out of every 10,000 Caucasian individuals. In India, the cases are unknown because of failure of doctors to diagnose HD as they never seen HD in their practice. Approximately 2.5 times more individuals are at risk for the disorder because of the midlife peak in age at onset.

About Authors:
NIKHIL SAXENA, DR.K.R.PARDASANI, DR.USHA CHAUHAN
MAULANA AZAD NATIONAL INSTITUTE OF TECHNOLOGY,
BHOPAL

ABSTRACT
The electro negativity of the drug directly resembles its chemical nature towards the receptor. In order to achieve the desired response, the effective binding of drug is necessary. Based on the Lock key theory, every drug having a specific structure so that it can bind to a specific receptor. But for designing more efficient a new chemical entity for receptor as compared to the main drug, there is a requirement of some structural changes in the drug (ligand) molecules under structure activity relationship concept. 
Here an attempt has been made to develop Insilco approach to make some structural changes on the basis of point mutation (changes occurs at a particular point) in the antiasthmatic drug namely salbutamol.
The effect of this mutation on binding affinity of the molecule is studied using docking energy (energy involved in orientation of one molecule to a second are when bound to each other to form a stable complex) calculations and logp values. Here eight different structures of the drug found are more electronegative as compared to the main drug candidate. Mutation was made at C-3a position in place of hydrogen. These were analyzed for binding affinity with target receptor. The mutated molecules which have high logp values and less energy are selected for further adme properties studies. Thus after prediction all adme properties and toxicity studies of the mutated drugs, the best mutation was bromine in place of hydrogen at C-3a position.

About Authors:
KAPIL V BIYANI¹, DR.P.S. KAWTIKWAR², N. M. MAHAJAN³
1. M.Pharm, IBSS COLLEGE OF PHARMACY,
BULDHANA ROAD, MALKAPUR (M.S)
2. HOD, SNIOP, PUSAD
3. HOD, IBSS COLLEGE OF PHARMACY,
BULDHANA ROAD, MALKAPUR (M.S)

Introduction^{1, 2, 3, 4, 5, 6, 7, 8}
Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard”and“soft”. The hard capsule is also called “two pieces” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage forms.

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About Authors:
Dr. M.B.SULOCHANA, PRASHANTH GADGI
Department of Biotechnology,
Gulbarga University,
Gulbarga, Karnataka,India

ABSTRACT
To determine the effect of rhizobium inoculation and nitrogen fertilizer on performance of Green gram, Bengal gram and Groundnut. Investigations were done in pot culture experiment under natural conditions. The research material consists of Green gram, Bengal gram and Groundnut varieties with treatment of seeds and Nitrogen fertilizer at 60kg/ha for green gram and Bengal gram, 120kg/ha for Groundnut. These treatments were compared against control (no inoculation). Data were recorded on Plant Growth parameters (seed germination, nodulation index, plant height at maturity, wet weight and dry weight) and soil nitrogen levels at the end of experiment. Among all treatments plant with seed inoculation was found effective in all three legume varieties compared to soil with nitrogen fertilizer and control.

About Authors:
RAVIKUMAR R. PATEL¹, Dr. JAYVADAN K. PATEL^2
1 Research Scholar, Jodhpur National University, Jodhpur
² Principal and Professor, Nootan Pharmacy College, Visnagar, Mehsana, Gujarat.

AIM OF PRESENT INVESTIGATION
Now a day most of the pharmaceutical scientists are involved in developing an ideal drug delivery system with an objective of not only curing the disease but also to achieve patient compliance. Approximately 50 % of the drug delivery system available in market is oral drug delivery system. Conventional oral dosage forms provide a specific drug concentration in systemic circulation without offering any control over drug delivery. Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of gastrointestinal tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems.

About Authors:
Madhu  dwivedi, Rishabha Malviya
Department of pharmaceutical technology
MIET,MEERUT

Introduction:
Natural polymer: A number of natural or partially modified polymers were screened for mucoadhesive properties by routinely measuring the force of detachment for swollen polymer films from pig intestinal mucosa in a saline medium. Suprisingly, hydroxypropyl- and carboxymethylcellulose showed almost no mucoadhesion, whereas the cationic polymer chitosan was fairly mucoadhesive in comparison to Polycarbophil as a reference substance. It is suggested that a strict difference be made between mucoadhesion of dry polymers on a wet tissue in air, and mucoadhesion of a swollen hydrogel in the presence of a third liquid phase. Cationic polymers should be further investigated with respect to possibly improved mucoadhesive properties in a neutral or slightly alkaline environment.