Articles

25 November 2013

A CRITICAL REVIEW ON PHARMACEUTICAL ANALYSIS OF NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (HETCOR SPECTROSCOPY)

About Authors:
Reshma. K*, M.Muthukumaran*, B.krishnamoorthy, Amreen Nishat
Montessori Siva sivani Institute of Science&Technology- College Of
Pharmacy
Vijayawada, Andhrapradesh-521 230
reshmakaaja@gmail.com

Abstract
Nuclear magnetic resonance (NMR) has progressed rapidly over the last decade as a result of improved experimental technology and development of novel approaches. NMR spectroscopy has evolved into an important technique in support of structure-based drug design. It was most useful as a technique to provide structural information regarding protein drug targets and target–ligand interactions. More recently, it has been shown that NMR may be used as an alternative method for identification of small molecule ligands that bind to protein drug targets. High throughput implementation of these experiments to screen small molecule libraries may lead to identification of potent and novel lead compounds. NMR as a probe of microscopic dynamic behaviour through relaxation and direct diffusion measurements over a wide temperature range is examined.
24 November 2013

DESIGN AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE

ABOUT AUTHORS:
Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G, Shardor A G*
Department of Pharmaceutics, SVET’s College of Pharmacy,
Humnabad- 585 330 (Karnataka).
ambarish.pharma@gmail.com
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ABSTRACT
Sustained release matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. For the purpose of enhancement the bioavailability of furosemide, a dosage form with sustained release of furosemide was designed in this study.
Sustained release tablets of furosemide were fabricated using xanthan gum(13.33 % to 66.67 %). Thepreparedtablets were evaluated for pre compression and post compression studies likeangle of repose, bulk density, tapped density, hardness, weight variation, fraibilty, drug content, in-vitro releaseof drugetc. among the five formulations A better controlled drug release (85 %) was obtained with the matrix tablet SX₅ containingxanthan gum66.67%. Short-term stability studies of all formulations indicates that there were no significant changes in drug content and dissolution parameter values after 3 month storage at 40° ± 2°C/75 ± 5% RH.
22 November 2013

MORGELLONS DISEASE

ABOUT AUTHORS:
Jyotirmoyee Patnaik
Kanak Manjari Institute of pharmaceutical Sciences.
Rourkela, Orissa
patnaik.jyotirmoyee@gmail.com

ABSTRACT:
Morgellons disease is a mysterious skin disorder that was first described more than 300 years ago. The disease is characterized by fiber-like strands extruding from the skin in conjunction with various dermatologic and neuropsychiatric symptoms Morgellons is a disease of skin lesions, where patients’ complain of itching with skin patches, discomfort and a feeling of something rolling under their skin, and finding fibers, whether single or in bunch on the surface of the skin, mostly on exposed areas such as the face, neck, chest, arms and other parts of the body. The signs and symptoms vary in different individuals.
20 November 2013

A REVIEW ON CHALCONES AND ITS IMPORTANCE

About Authors:
Vishwanadham Yerragunta*, T.Kumara swamy, D.Suman, V.Anusha, Prathima Patil, T. Samhitha
Department of Pharmaceutical Chemistry,
Vishnu Institute of Pharmaceutical Education and Research,
Narsapur, Medak – 502313, A.P.
Vishwanadham.y@gmail.com
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Abstract:
Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be synthesized in laboratory. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. Chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of synthetic chalcones, studying importance of chalcones, and synthesis of pharmacologically active chalcones and their biological activities.
19 November 2013

ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY

About Authors:
Jasinth. Danda*, Dr. P.Venkateswara Rao, P.Rama Bharathi, B.Madhavi, T.Swathi, Satya Lakshmi. Balla
A.M Reddy Memorial College of Pharmacy,
Department of Pharmaceutical Analysis
Narasaraopet, ANU University, Guntur.
Jasinthdanda18@gmail.com
18 November 2013

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND EPERISONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS

About Authors:
Venkata Anil Kumar Sistla*, Dr.P.Venkateshwara Rao, P.Rajavel
Department of Pharmaceutical Analysis
A.M.Reddy Memorial College of Pharmacy,
Narasaraopeta - 522601,
Guntur Dt, India.
*anilkumar5831@gmail.com
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17 November 2013

SUCCESS STORIES OF ENOLATE FORM OF DRUGS

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About Authors:
Arvind Negi¹*, Balraj Singh Gill²
¹Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
²Centre for Biosciences, Central University of Punjab, Bathinda-151001
*arvindnegi2301@gmail.com

Abstract
Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enol form ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!
15 November 2013

INDIAN PATENT AND INDIAN PATIENT, FRIEND OR RIVAL: A COMMUNICATION

ABOUT AUTHORS:
Prathima Patil*¹, Tahseen Sameena¹, S.P.Sethy, K.Shailaja¹, P.Mishra²
¹Department Of Pharmaceutical Chemistry, Sushrut Institute of Pharmacy
Taddanpally (V), Pulkal (M), Medak-502293.
²Department Of Pharmacology, Malla Reddy College Of Pharmacy
Maisimaguda, Dhulapalli, Secundrabad-14
pratima.patil0@gmail.com

ABSTRACT:
Though patents are effective tools for promoting innovation and protecting intellectual property in the pharmaceutical sciences, there has been a growing concern that the current scenario of patient and patent is not vivid in developing countries like India. A lot of complications arise when a pharmaceutical firm applies for patent for their product in developing countries. Innovation in global health care needs patent protection as a safeguard, so patent is a must requires item for health care industries. We can say Patent as a fuel for innovation simultaneously it can burn the pocket of economically backward patients in developing countries. But this thing should not happen as both patent and patient needs each other. A friendly relationship should exist between them. In this context we have discussed about various aspect of patent and patient related issue and also about sensible solution for the issue.
14 November 2013

REVIEW ON ANTI AGING

ABOUT AUTHOR:
Sayoni Sengupta
M.Pharm 1st Sem.
Kanak Manjari Institute of Pharmaceutical Sciences
Rourkela, Orissa
bonirini@hotmail.com

ABSTRACT
Aging is the accumulation of changes in person overtime. Aging in humans refers to a multidimensional process of physical, physiological and social changes.
Recent studies have revealed that certain medicinal herbs are effective in the intervention or prevention of aging and also in the eradication of age associated disorders. Herbs used in anti-aging programmes have medicinal properties which stimulate the vital organs in the body and restore their normal function. Many of them possess antioxidant properties.
Ginseng derived from the Chinese term, belongs to the genus Panax, of the family Araliaceaeby the presence of ginsenoside.
Recent studies explain the exotic role of Panax ginseng’s ginsenoside in promoting neurological health support and also state its beneficial effects in anti-aging and nerve related problems.
14 November 2013

ANAPHYLACTIC SHOCK: SHOCKING ERROR OF IMMUNE SYSTEM!

About Author:
Arvind Negi
Centre for Chemical and Pharmaceutical Sciences
Central University of Punjab, Bathinda-151001
arvindnegi2301@gmail.com
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Abstract
Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!