Articles

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ABOUT AUHTORS
SRIJITA DUTTA
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
BENGAL SCHOOL OF TECHNOLOGY
Hooghly,  West Bengal
srijitadutta1991@gmal.com

ABSTRACT: Biotechnology is a manipulation technology of living organisms and organic material to serve Human Needs. To make a better world some basic need (sufficient food, healthy life, eco-friendly/anti-polluted environment and employment) of the people should be fulfill. For that biotechnology can be used to struggle with these issues

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Jaha Sultana Mohammed
Pelcat Formulation PVT ltd
sohnivya786@gmail.com

ABSTRACT:
Ion exchange chromatography is probably the most powerful and classic type of liquid chromatography. The popularity of ion exchange chromatography has been increased in recent years because this technique allows analysis of wide range of molecules in pharmaceutical, biotechnology, environmental, agricultural and other industries for water purification to separation of various antibiotics from fermentation broths which will enhance the yields and reduce the production time for industrial process. The main objective of this particular study is to develop some understanding for the process of ion exchange and helps to determine whether or not ion exchange will be useful for a particular application. This topic includes background, theory, instrumentation, application which covers both the production of the ion exchange substance, a resin and its operation depending on the condition of matrix during use.

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ABOUT AUHTORS
Suleman S. khoja 1 , Sohil S. khoja 1,
Farhad S. Khoja 2,Shamim Khoja2,Narmin Pirani2
1)Resource person in pharmaceutical quality assurance and Audit Compliance,VAPI 2) Registered Pharmacist , Gujarat
Suleman salim khoja
Email: premukhoja@gmail.com

Scope 
Human Error is commonly defined as “a failure of a planned action to achieve a desired outcome”. GMPs clearly state in CFR 211.22 that “[the quality control unit has]…the authority to review Production records to assure that no errors have occurred or, if errors have occurred, that they have been fully investigated.” Let’s analyze this statement. If the FDA expects that errors be fully investigated, it is safe to assume that the term error is NOT a root cause. That’s why it needs to be fully investigated, hence determine the root cause of the human error.  In order to successfully achieve this goal, we have to understand how to improve the way we deal with these types of situations. review article accurately how to accurately identify human errors, determine when a deviation or nonconformance requires CAPA, and get started using human performance improvement tools and processes in your organization.

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Abhijit De*, Chandan Ghosh
Department of Pharmaceutical Science,
Bengal School of Technology, Sugandha,
Hooghly, West Bengal, India
* abhi8981@gmail.com

ABSTRACT
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. In this review, several theories and mechanisms have been put to explain the molecular basis of aging. For example, random damage of the DNA of somatic cell is believed to accumulate with increasing age. Free radicals produced during oxidation of metabolites for energy production also damage DNA and proteins.

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ABOUT AUTHORS
Bhumika Kumar*
Department of pharmaceutics,
Delhi pharmaceutical sciences and research university,
New Delhi, India

ABSTRACT
Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability.  The water soluble carriers used in preparation of solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focuses on the methods of preparation, advantages, disadvantages and characterization of the solid dispersions.

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ABOUT AUHTORS
Jaha Sultana Mohammed
Pelcat Formulation PVT
sohnivya786@gmail.com

ABSTRACT
The purpose of cleaning validation is to establish the documented evidence with high degree of assurance that the cleaning process followed as per standard operating procedure for cleaning the equipment used for the processing, consistently and concurrently yields the results not exceeding predetermined acceptance limit. The main objective of this particular study is to develop some understanding for the process of validation and its type along with importance of cleaning validation in pharmaceutical industry to prevent cross contamination. This topic includes Types of validation, cleaning validation, Levels of cleaning Validation, Cleaning mechanisms, cleaning agents used and process followed by pharmaceutical industry to achieve cleaning validation. The various methods used for cleaning validation are clearly discussed in this review.

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  ABOUT AUHTORS
AKASH S MALI^1,2*,AUDRIUS MARUŠKA^2
1University of Würzburg Germany.
²Vytautas Magnus University, Lithuania
*Akashmit97@gmail.com

ABSTRACT
Pharmaceutical gases molecules (Therapeutic medical Gases) are plays vital role in various disease conditions. In particular, Carbon monoxide, Oxygen, Nitric oxide, Hydrogen sulfide are generated in the human body and mediate signaling pathways as biological messengers and shown pharmacological effects on cardiovascular disorders, nervous system, respiratory track and gastrointestinal disorder. Appropriate oral delivery of gases is challenging concept in front of novel drug delivery system, recently microbubbles, nanobubbles, liposomes, ultrasound technology provides new oral and parenteral delivery platform for therapeutic gases. This review provides pharmacological effects of therapeutic medical gases and its novel delivery aspects.

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ABOUT AUHTORS
Nisha Sharma, Mahroz, Deepak Chowrasia*
University Institute of Pharmacy,
Chhatrapati Shahu Ji Maharaj University, Kanpur, U.P.,  India
chowrasia.deepak@gmail.com

ABSTRACT
Chemically chalcones are 1,3–diphenyl-2-propene-1-one, containing dual aromatic rings which are linked to each other via carbon bridge system enveloping keto-ethylenic core structure. Owing to the presence of conjugated double bond and electron dense aromatic ring system, the molecule posses less redox potential; thus greater probability for characteristic electron transfer reactions. Naturally, conjugated systems of these types are abundantly present in edible plants and are considered to be precursors of bioactive flavonoids and bioflavonoids. Chalcones and their derivatives find numerous industrial applications such as artificial sweeteners, scintillator, polymerization catalyst, fluorescent whitening agent, organic brightening agent, stabilizer against heat, visible light, and ultraviolet radiation.  As a chemo-identifying agent, chalcones have been found useful in elucidating structure of natural products like hemlock, tannin, cyanomaclurin, ploretin, eriodictyol and homoeriodictyol, and naringenin. Pharmacologically, the same molecule acts as a versatile and universally accepted moiety for design and development of numerous bioactive synthetic analogues in search of ideal medicine to conquer human pathological conditions.  The present paper thus designs to explore and study various prospective of chalcones and their derivatives in terms of recent developments and pharmacological importance.