Articles

About Authors:
Divya Rawat, U.K.Singh, Faizi Muzaffar
Kharvel Subharti College of Pharmacy,
swami Vivekanand subharti university, Subhartipuram,
N.H-58, Meerut By Pass Road, Meerut, Uttar Pardesh-250001, India
*drawat05@gmail.com

Abstract
Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres, different methods to preparation, its applications and also various parameters to evaluate their efficiency.

ABOUT AUTHORS:
G.Venkateswarlu*, M.Muthukumaran, B.krishnamoorthy, Ameren nishat
Montessori Siva Sivani Institute of Science & Technology College of Pharmacy-Mylavaram,
Vijayawada, Andhra pradesh-521230
*venkateswarlu460@gmail.com

ABSTRACT
The goal of this review is to provide a guide for understanding current MS technology. Mass spectrometry (MS) has progressed to become a powerful analytical tool for both quantitative and qualitative applications. Proteomics research, in particular, increasingly depends on MS technologies. Basically, any information gathered from a mass spectrometer comes from the analysis of gas-phase ions. There are three main components of a mass spectrometer: an ionization source, a mass analyzer and a detector the name ‘mass spectrometry’ is a misnomer of sorts. The mass is not what is measured; instead, mass spectrometry determines the mass-to-charge (m/z) ratio or a property related to m/z .A mass spectrum is a plot of ion abundance versus m/z, although in many cases the x-axis is labelled ‘mass’ rather than m/z. The spectrum is presented in terms of Daltons (Da) per unit charge The ability of mass spectrometry analyzing proteins and other biological extracts is due to the advances gained through the development of soft ionization techniques such as electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) that can transform biomolecules into ions. Regardless of the ionization source, the sensitivity of a mass spectrometer is related to the mass analyzer where ion separation occurs.  

About Authors:
Kritika Rastogi, U.K. Singh, A.K. Chaturvedi
Kharvel Subharti College of Pharmacy, (swami vivekanand subharti university) subhartipuram,
N.H-58, Meerut By Pass Road, Meerut, Uttar pradesh-250001,India.
*kritikarastogi6@gmail.com

Abstract
Insulin remains the most effective and durable hypoglycemic agent for the treatment of diabetes. Insulin is a major protein hormone secreted by beta –cells of the pancreas and is important for the control of diabetes. Insulin has an important place in drug therapies for insulin dependent diabetes mellitus (type I) and for many patients with non-insulin-dependent diabetes mellitus (type II). It would be highly advantageous if insulin could be administered orally, because the oral delivery of insulin can mimic the physiological fate of insulin and may provide better glucose homeostasis. The desire to deliver protein and peptide biopharmaceuticals conveniently and effectively has led to the intense investigation of targeted delivery systems. The goal of oral insulin delivery devices is to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.

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About Authors:
Miss Tejaswini Sharma ^1*, Mr. Govind Bhandari ^2
1MAHAKAL INSTITUTE OF PHARMACEUTICAL STUDIES, UJJAIN (M.P.)  456010
²ASSISTANT PROFESSOR,
MAHAKAL INSTITUTE OF PHARMACEUTICAL STUDIES, UJJAIN (M.P.)  456010
*Sharma.tejaswini@gmail.com

ABSTRACT:
The psychosomatic disorders are variant in nature and to get rid of this problem, we must understand the basics of its causative factors and their effects on sole body.
Now being herbal drugs are comparatively less toxic and has negligible side effects the use of these drugs on such type of disorders are quite encouraging. So here is the brief study on seldom diseases and their causative factors, and treatment part by herbs accordingly discoursed.

ABOUT AUTHORS:
Mr. Kulkarni Sarang*,Birajdar Shivprasad M., Shaikh Parvej H., Dr. Poul B.N
Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
*sarangkulkarni342@gmail.com

ABSTRACT
Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the fast disintegrating tablets with improved patient compliance and convenience. Fast disintegrating tablets are solid dosage forms which dissolve rapidly in saliva without chewing and additional water. Fast disintegrating tablets overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in paediatric and geriatric patients. Natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. They can also be modified in different ways to obtain tailor- made materials for drug delivery systems and thus can compete with the available synthetic excipients. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. The natural superdisintegrants can be used instead of synthetic superdisintegrants as they showed equal disintegrating property as that of synthetic agents or dispersible tablets.

ABOUT AUTHOR:
BINDU.S
ANNAMACHRYA COLLEGE OF PHARMACY,
RAJAMPET,KADAPA Dist, A.P, INDIA.
sirasalabindupharmacy@gmail.com

INTRODUCTION
Rock salt, also known as halite is the naturally occurring crystalline salt. It is the mineral form of sodium chloride or the table salt that we use. However, rock salt does not look like the regular table salt. Instead, it naturally forms in large isometric crystals. Moreover, rock salt can be white like table salt or it can be red, orange, yellow or blue in color. The color of rock salt basically depends on the amount, and the kind of impurities present in it. Along with sodium, rock salt contains many other minerals including, calcium, zinc, iron, magnesium, potassium, copper and several other trace minerals. Like table salt, rock salt too has great many uses. rock salt in massive bags for the purpose of keeping down ice on the roads in the winter.

About Authors:
Chandan bisht^1*, Dr.Jagannath sahoo², Dr.M.Irfan Khan^3
1,2 Shri Ram Murti Smarak college of Eng. & Tech( department of pharmacy) Bareilly.
³ Deccan Healthcare pvt. Ltd. Pantnagar industrial area
*chandanbisht2011@gmail.com

Abstract:
Mouth dissolving tablets (MDT) are useful in patients, such as pediatric, geriatric, bedridden, or developmentally disabled, who may face difficulty in swallowing conventional tablets or capsules and liquid orals or syrup, leading to ineffective therapy, with persistent nausea, sudden episodes of allergic attack, or coughing for those who have an active life style. Over the past three decades, mouth dissolving tablets have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance The objective of this article is to review the development of MDTs, challenges in formulation,  benefit, limitation ,new MDT technologies and evaluation methodologies.