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  • EDIBLE VACCINES

    About Author:
    K.Kranthi Kumar
    SKU College of Pharmaceutical Sciences,
    S.k.univrsity, Anantapur
    kranthikumarkotta@gmail.com

  • VISUAL INSPECTION WITH ACETIC ACID FOR CERVICAL CANCER SCREENING- AN EFFECTIVE STRATEGY IN LOW-RESOURCE SETTINGS

    ABOUT AUTHORS:
    Dr. Balram Soni*
    M.Pharm., Ph.D.
    Psychiatric Centre, S.M.S. Medical College Jaipur, Rajasthan
    brpharma@rediffmail.com

  • BARBITURATES – AN ABUSE

    About Author:
    Pooja Dhiman
    Lecturer
    Chitkara University, Solan [H.P]
    Pooja.dhiman@chitkarauniversity.edu.in

    The WHO defines drug abuse as “persistent or sporadic excessive drug use inconsistent with or unrelated to acceptable medical practice.” Barbiturates are the drugs which act on the central nervous system and produce depression.

  • H2S : REVOLUTIONARY SCIENTIFIC MIRACLE AS A GASOTRANSMITTER AT MAXIMUM POTENTIAL IF USED WISELY

    ABOUT AUTHORS:
    Krishna J. Kathawala1*, Gaurav L. Ninama1, Ankitkumar Y. Parikh1, Krupali V. Upadhyay2
    1A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy B/H. B & B Polytechnic College, Vallabh Vidyanagar - 388 120, Gujarat, India.
    2Shree Satsangi Saketdham “Ram Ashram” group of Institution, At. & Post. Vadasma, Tal. & Dist. Mehsana, Gujarat – 382708, India.
    *krishna.kathawala@gmail.com

    ABSTRACT
    Nitric oxide (NO) and Carbon monoxide (CO) are the reputed neurotransmitters involved in the regulation of vascular tone. H2S, which synthesized from L-cysteine, can play more vital role as Gasotransmitters compare to NO and CO. H2S have a role as a stimulator of ATP-sensitive potassium channels (KATP-channels) in the vascular smooth muscle cells, neurons, cardiomyocytes and pancreatic β-cells. H2S also minimize the toxic effect by reacting with reactive oxygen and/or nitrogen species and attenuating their physiological functions. H2S have a unique feature of not to stimulate soluble guanylate-cyclase like other Gasotransmitters. H2S plays a critical role in the regulation of vascular tone, neurotransmission, insulin secretion, and myocardial contractility. Recent studies showed that, in various animal models of arterial and pulmonary hypertension, Alzheimer’s disease, gastric mucosal injury and liver cirrhosis had H2S deficiency which defines the significance of H2S. Exogenous H2S alleviates myocardial dysfunction associated with the ischemia/reperfusion injury with reducing the damage of gastric mucosa generated by anti-inflammatory drugs. H2S had also some drawbacks like every coin has two sides. Excessive production of H2S may contribute to the pathogenesis of inflammatory diseases, septic shock, cerebral stroke and mental retardation in patients with Down syndrome, and reduction of its production may be of potential therapeutic value in these states. Preclinical evidence is provided to show that H2S releasing derivatives of several NSAIDs, including Diclofenac and Indomethacin indeed represent excellent gastrointestinal safety and are more potent than the parent drugs as anti inflammatory agents. Derivatives of anti-inflammatory drugs other than NSAIDs (e.g. mesalamine) have also been shown to be significantly improved over the parent drug in many respects. So, H2S can be Revolutionary scientific miracle as a gasotransmitters  at maximum potential if the drawbacks are minimize by cutting edge solution.

  • AN OVERVIEW ON PHARMACOVIGILANCE

    ABOUT AUTHORS:
    Jain Deepika*, Rathore Kamal Singh
    BN Institute of Pharmaceutical Sciences,
    Udaipur-Raj.313002 INDIA
    *dpka88jain@gmail.com

    ABSTRACT
    Pharmacovigilance is particularly concerned with adverse drug reactions, or ADRs, which are officially described as: “A response to a drug which is noxious and unintended, and which occurs at doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological function”. The mission of Pharmacovigilance is to contribute to the protection of public health in the regulation of the safety; quality and efficacy of medicines for human use and to ensure the healthcare professionals and patients have access to information about the safe and effective use of medicine. The World Health Organization (WHO) defines an adverse drug reaction (ADR) as “Any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease or for modification of the physiological function”.

    The discipline of pharmacovigilance has developed considerably since the 1972 WHO technical report, and it remains a dynamic clinical and scientific discipline. It has been essential to meet the challenges of the increasing range and potency of medicines (including vaccines), which carry with them an inevitable and sometimes unpredictable potential for harm. The following is a summary of some of the serious challenges facing pharmacovigilance programmes in the next ten years & the major challenges are:Globalization, Web-based sales and information, Broader safety concerns, Public health versus pharmaceutical industry economic growth , Monitoring of established products, Developing and emerging countries, Attitudes and perceptions to benefit and harm, Outcomes and Impact.

  • SEX DETERMINATION USING POLYMERASE CHAIN REACTION

    About Authors:
    Emanual Michael Patelia*, Rakesh Thakur, Jayesh Patel
    Department of Pharmacology,
    University of Bedfordshire, Luton, LU1 3JU, England.
    *ricky.emanual@gmail.com

    Abstract
    The PCR is widely used technique in sex determination. PCR is also used for the determination of x linked inherited disorders, with help of biopsied embryos into mothers. DNA polymerase enzyme replicates a piece of DNA. Thus, chain reaction occurs and generating multiple copies of it. Polymerase chain reaction is frequently used technique for sex determination. PCR can also be used for detecting the presence or absence of a particular piece of DNA. In this method, we used PCR method for determination of the sex of three unknown bovine samples.PCR techniques have developed to reduce the problems by increasing amplification quality.

  • GASTROENTERITIS: NATURE AND PREVENTION

    ABOUT AUTHOR:
    Raj Kishor
    Avigna Clinical Research Institute
    Bangalore
    raryan859@gmail.com

  • CERVICAL CANCER VACCINE- A REVIEW

    ABOUT AUTHOR:
    Mamta Yadav
    M.Pharm
    Sagar Institute of Research Technical And Science-pharmacy
    Bhopal (M.P)
    mamtayadav811@gmail.com

  • BIPOLAR DISORDER – AN OVERVIEW

    About Authors:
    Dipal Patel*1, Dr. Kamal Singh Rathore1, Twinkal Patel2
    Department of Pharmacology
    1B.N. Institute of Pharmaceutical Science, Udaipur (Rajasthan), 313001
    2Shri Sarvajanik college of Pharmacy, Mehsana (Gujarat).
    *dipalpatel786@gmail.com

  • PHYTOTHERAPY OF CANCER - A BRIEF OVERVIEW

    About Author:
    Mridula Jayaraman,
    Amity Institute of Pharmacy,
    Amity University, India
    mridulajayaraman1990@gmail.com

    Abstract
    The word ‘cancer’ itself sends chills down our spines as its prognosis and treatment, even if detected at an early stage is cumbersome and tortuous. With the advent of modern medicines, even though it is claimed that cancer is curable, there exists virtually no chemotherapeutic agent for cancer without side effect(s), not to mention the cost of these medicines which are skyrocketing.
    Hence, we are left with little choice but to go for new fronts in research on the therapeutic agents present in plants (Phytotherapy), which are not only cost effective but also relatively side effects free.  These plants are available in plenty in the Himalayan and Aravali Region of India.  
    University
    of Wisconsin lists 150 plants which they have established as having potential value in the treatment of cancer.  However, the real issue here is that not many drugs derived from plants have been standardized and standardization of these plants for therapeutic purpose is still in the nascent stage.

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