Pharmacology Articles

15 July 2013

CERVICAL CANCER A CURSE FOR GROWING AGE WOMEN: (A REVIEW)

About Author:
Shambhavi Singh
M.pharma, Singhania University
Jhunjhunu, Rajasthan
Shambhavisingh6777@gmail.com

Abstract
Based on the figures from the World Health Organization, more than 20 lakhs women die worldwide because of cervical cancer per year. Cervical cancer, a potentially preventable disease, found as the second most common malignancy in women worldwide. In India, the disease accounts for a probable 24 percent of India’s cancer cases among women and in addition to that 74,000 Indian women die annually from the disease, which results from the unusual growth of cells in the cervix. Cervical cancer is the most frequent disorder among women age near about 50 that increased the death rate in Indian rural women as compared urban due to lack awareness and don’t gain proper education. Cancer causing growth in the cervix is not a solitary type. It is not usually linked with hereditary genetic factor but a number of variable factors (Chemical, environmental and biological) indirectly enhance the risk of cervical cancer by increasing the possibility that a woman can contact an HPV infection. National Cancer Control Program emphasizes the significance of early detection and treatment. But our country has no well thought-out screening program and many women in India lack information regarding the disease and way to prevention and treatment facilities. Therefore, it is most of important to treat properly cervical cancer and make awareness in Indian women regarding its treatment and proper management.

12 July 2013

REVIEW ON GOLD NANOPARTICLES FOR CANCER TREATMENT

About Authors:
M. B. Shinde*, S.V.Usnale¹, M. B. Sorde², O.V. Kolgire³
Department of quality assurance,
Maharashtra College Of Pharmacy, Nilanga.
Dist- latur (MS)
*maheshinde7@gmail.com

9 July 2013

COMPARATIVE STATUS OF OXIDANT/ANTIOXIDANT IN PREGNANCY INDUCED HYPERTENSION AND CERVICAL DYSPLASIA

About Author:
*Seema Singh¹, Sandeep Kumar Singh²
¹Department of Pharmacy, Northern India Engineering College, Lucknow (U.P.) India
²Department of Pharmaceuticals Sciences, Dr. H S Guar University Sagar (M.P.), India
*seema_b.pharm@rediffmail.com

Abstract:
Present study is aimed to delineate a co-relation between status of anti-oxidant enzymes, lipid peroxidation products with severity of Pregnancy Induced Hypertension (PIH) and cervical dysplasia. The study has been done on 66 patients out of whom 14 were normal pregnancy and had no disease, 31 patients of PIH and 21 patients having cervical dysplasia gr. I-II. Enzymatic activities of Superoxide dismutase (SOD), Catalase (CAT), vitamin C and vitamin E and malonaldehyde levels (MDA, a marker of lipid peroxides) were assessed spectrophotometrically. Mean Malonaldehyde level in PIH patients (8.48 ± 0.96) & Cervical patients (8.31 ± 1.25) in comparison to normal patients (4.88 ± 1.035), the rise was found highly significant (p < 0.001). The enzymatic activity of antioxidants such as Superoxide dismutase, Catalase, vitamin C and vitamin E was decreased in PIH patients & cervical dysplasia patients as compared to normal patients (p < 0.001). The difference was statistically significant (p < 0.001) whereas the same was observed in cervical dysplasia patients. No statistically difference was observed between the levels of antioxidants of PIH patients & cervical dysplasia patients (p < 0.01). Co-relation of Hb with MDA level showed that aneamic patients have raised level of MDA as compared to non aneamic patients. There is positive oxidant/antioxidant balance which may aggravate free radical damage during pre eclampsia and eclampsia with cervical dysplasia.

8 July 2013

PERIPHERAL VASCULAR DISEASES: AN UNDERDIAGNOSED CAUSE OF PAIN

ABOUT AUTHORS:
Patil Reshma R.*, BhutkarM.A., Gaikwad Pranita T.
Rajarambapu College of Pharmacy, Kasegaon,
Maharashtra 415405 India
*Patil.reshma1990@gmail.com

4 July 2013

A REVIEW ARTICLE ON SYNRIAM INDIAs FIRST ANTI-MALARIAL DRUG

ABOUT AUTHOR:
Shikha Patel
M.pharm (Quality Assurance), Sagar Institute of Research and Technology-Pharmacy
Bhopal (M.P)
siyapatel2007@gmail.com

24 June 2013

TRIAL DESIGN AND CONTROL OF ANTIHYPERTENSIVE IN CLINICAL RESEARCH

ABOUT AUTHOR:
Raj Kishor
Avigna Clinical Research Institute
Bangalore, India
raryan859@gmail.com

23 June 2013

ZALTOPROFEN: AN EFFECTIVE NSAID FOR PAIN MANAGEMENT

ABOUT AUTHORS:
Saxena Vaishali*, Bhale Shweta, Dantoriya Sanjay, Mathariya Arun k., Mahajan S.C., Bhandari Govind
Mahakal Institute of Pharmaceutical studies,
Ujjain (m.p)
*vaishali.saxena0390@gmail.com

20 June 2013

DETERMINATION OF PURITY AND RELATIVE MOLECULAR WEIGHT OF PURIFIED HUMAN IgG

About Authors:
¹M Prasad Naidu, ²Dr Madhu Sudan Reddy, ³T Madhu Chaithanya, ⁴N Mallikarjun Rao
¹(Medical Biochemistry) NMCH, Nellore, AP, India.
²(MD Pharmacolgy) NMCH, Nellore, AP, India.
³(Medical Pharmacology) MIMS, Vijayanagaram, AP, India.
⁴(MSc Botany). Acharya Nagarjuna University, Guntur, AP, India.
*www.prasadnaidu.com@gmail.com

Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
An important technique for the separation of proteins is based on the migration of charged proteins in an electric field, a process called electrophoresis. These procedures are not generally used to purify proteins in large amounts, because simpler alternatives are usually available and electrophoretic methods often adversely affect the structure and thus the function of proteins. Electrophoresis is, however, especially useful as an analytical method. Its advantage is that proteins can be visualized as well as separated, permitting a researcher to estimate quickly the number of different proteins in a mixture or the degree of purity of a particular protein preparation. Also, electrophoresis allows determination of crucial properties of a protein such as its isoelectric point and approximate molecular weight. The polyacrylamide gel acts as a molecular sieve, slowing the migration of proteins approximately in proportion to their charge-to-mass ratio. Migration may also be affected by protein shape. In electrophoresis, the force moving the macromolecule is the electrical potential, E. The electrophoretic mobility of the molecule, µ, is the ratio of the velocity of the particle molecule, V, to the electrical potential. Electrophoretic mobility is also equal to the net charge of the molecule, Z, divided by the frictional coefficient, f, which reflects in part a protein’s shape.

18 June 2013

CANCER PATIENTS UNDERGOING CHEMOTHERAPY TO DEVELOP DEPRESSION

ABOUT AUTHORS:
Ashutosh Kumar Dubey*^[1], Vishal Jackob^[1], Srishti Srivastava^[1], Anusha Srivastaav^[2]
¹Institute of Foreign Trade and Management
²Rajiv Academy of Pharmacy
*srishtiiftm@gmail.com

12 June 2013

DETERMINATION OF HER2 STATUS IN ER POSITIVE HUMAN BREAST CANCER

About Authors:
Emanual Michael Patelia*, Kunal Patel, Mikul Patel
Department of Pharmacology,
University of Bedfordshire,
Luton, LU1 3JU, England.
*ricky.emanual@gmail.com

Abstract:
According to the method (BCA), it is used for the quantitative analysis of proteins. It is used for the determination of unknown sample of protein. The sds-page is used for the identification of proteins though the separation. According to the gel image the sample of protein is ER-α and HER positive. So, the person needs the therapy for ER-α and HER positive breast cancer. The amino-terminal region was consistently detected in the cell nucleus by specific immunohistochemistry leading to the concept of a potential intranuclear association between ER cleavage products and/or other regulatory proteins. Human epidermal growth factor receptor 2 (HER2) belongs to the family of epidermal growth factor receptors (EGFRs). The availability of specific antibody-based test systems is essential to testing of HER2 protein expression.

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Pharmacology Articles

CERVICAL CANCER A CURSE FOR GROWING AGE WOMEN: (A REVIEW)

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