CINNAMON: A MAGICAL DRUG
Cinnamon is obtained from the leaves and has the hypotensive effects. Cinnamophyllin is obtained from Cinnamomum philippinensis and is a potent TXA2 receptor antagonist. In TXA2 disorders such as platelet aggregation this can be useful. Amin et al identified the activity of cinnamon and atorvastatin Hepatic enzyme activity, antioxidant capacity, nitric oxide etc. NO values and antioxidant activity where found to be increased in rats which were treated with cinnamon and atorvastatin than untreated. Later cinnamaldehyde and cinnamic acid were isolated from cinnamom cassia. Thus this provides the evidence for the cardioprotective action of cinnamon.
Cinnamaldehyde was synthesized and was tested for inhibition against angiogenesis. When cinnamaldehyde was made to react with ethanolic extract of C.cassia it stimulates Nrf2 levels. Pretreatment also stimulates the cellular GSH levels and protects HCT116 cells against genetoxicity induced by hydrogen peroxide. When combined all the things together cinnamaldehyde is a powerful activator of Nrf2 and may show an unappreciated anticarcinogenic activity. The site of target for anticancer activity of extract of cinnamon is the vascular endothelial growth factor (VEGF).It is one of the potent natural inhibitor of Nitrogen-activated protein kinase and stat3 mediated signaling pathway. This helps in the prevention and treatment of cancer. Varalaxmi et al showed that apoptosis was increased on treating with methanolic extract in the human hepatoma cancer cells.
The various properties, uses, characters of cinnamon were came across in this study of the article. These research and advancements must be reported and must be documented for the future generations for their well being.
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