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Smt. KishoritaiBhoyar College of Pharmacy, Kamptee was established in the year 1997-98 with an objective to nurture the pharmacy education and to support the healthcare system through skilled Pharmacy graduates. The Institute offers D.Pharm. (Two Years Diploma course in Pharmacy), B.Pharm (Four years Degree course in Pharmacy), M.Pharm (Two years PG program) specialization : Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Quality Assurance and Ph. D Program in Pharmaceutical sciences affiliated to RTM Nagpur University, Nagpur. & Maharashtra State Board of Technical Education, Mumbai.
ABOUT AUTHORS: Mistry Ripal*, Haresh T. Mulani
Department of Pharmaceutics
Indubhai Patel College of Pharmacy and Research Centre,
Dharmaj, Gujarat *rx.ripalmistry@gmail.com
ABSTRACT:
Diabetes mellitus, or simply diabetes, is a chronic disease that occurs when the pancreas is no longer able to make insulin, or when the body cannot make good use of the insulin it produces. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The success of oral hypoglycemic drug therapy is usually based on are storation of normal blood glucose levels. Traditionally, the term oral hypoglycemic was used interchangeably with sulfonylureas, but more recently the development of several new drugs has broadened this designation to include all oral medications for diabetes. Nateglinide, a D-phenylalanine derivative, is a novel insulinotropic drug which has recently been launched as a therapeutic agent for Type II diabetes. Clinical studies have shown that nateglinide induces a rapid onset of insulin release synergistic with meal administration which effectively restores the early phase of insulin secretion. Since the loss of early insulin secretion is thought to play an important role in the development of glucose in tolerance the ability of nateglinide to promote early insulin release is potentially of considerable therapeutic benefit.
About Authors: Keyur S. Patel*, Mital Mehta
Department of Pharmacology,
Anand Pharmacy College, Anand.
Gujarat, India. keyurpatel200189@gmail.com
Abstract
Drug-induced liver injury (DILI) has become a leading cause of severe liver disease and withdrawal of an approved drug from the market. DILI accounts for acute liver failure, liver transplantation or death in the United States today. A recent retrospective study indicates that the risk of DILI is enhanced when the administered daily dosage is higher than 50 mg or when the drug undergoes significant liver metabolism. Hence airs a major clinical and regulatory challenge.
This review Sum up Direct mitochondrial impairment and Specific drug induced mitochondrial dysfunction, current mechanistic concepts of DILI in a 2-step model that limits its principle mechanisms to this main ways of initial injury. Umpteen Studies that evaluate the risk of hepatotoxicity from Statins in Hyperlipidemic Patients. In this article, It will review the pathogenesis of drug induced mitochondrial liver toxicity and deleterious consequences of Atorvastatin.
About Authors: Navgeet1, Balraj Singh Gill2, Arvind Negi3*, Shashi Shekhar Anand2 1Institute of Himalayan Bioresource and Technology (CSIR-IHBT), Palampur (HP) 2Centre for Biosciences Central University of Punjab, Bathinda (Punjab) 3Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda (Punjab) *arvindnegi2301@gmail.com, arvindnegicup@gmail.com
Abstract:
Recent years have been witnessed for exhaustive genome sequencing, nourishing a cause to track the mutation and its consequences at the phenotypic level. But reliability of these genomic studies is the critical issue which is still unaddressed and not properly understood. Moreover via TILLING techniques (reverse genetic tool), can be valuable in evaluation of these studies to much extent. Usually TILLING account on a specific gene mutation in order to observe the extent of the functionality of that particular gene at morphological level. This review compiles the literature pertaining to the art of tilling in the evaluation of genomic studies and majorly in concern of functional genomics. Moreover this review also covers the example of the most common species so as to build better understanding of the concept behind this technique of reverse genetics and can be fruitfully applied in extractingthe ethano-botanical and therapeutic effect of various medicinal plants.
Introduction
Education leads to development of an individual and these individuals are expected to develop the larger mass of people, constituting society, city and ultimately nation. Education must deliver the result. A proper education and allied training make a person job-ready. Cut throat competition is taking its toll and students are taking extreme steps. This cut throat competition prevailing in almost all domains is changing equations across human resource (HR) departments. In pharmaceutical sciences opportunities are like never before. This sentence may sound ridiculous to some and some may approve it. First of all, let me demystify the fact that pharmaceutical sciences involve many sciences so students end up with the tag “Jack of all, master of none”. Why one forgets that pharmaceutical sciences mean (in broader sense) discovering-developing and launching new molecules and this is not possible by a person sound in only one stream/subject. This is not the job of every Tom, Dick and Harry or any Tom, Dick or Harry. Here comes the role of graduate or post graduate who has tremendous knowledge of the relevant field. Jobs are aplenty, especially after India became signatory country in newer patent laws (process patent since 2005). These news rules forced the closing of many reverse engineering chapters; but the silver line is that it also forced Indian pharma think tank to discover new molecules, which will require trained and talented man power. Credit for first such molecule goes to Ahmadabad based Cadila Healthcare Ltd. This article very precisely highlights the job scenario and allied aspects.
Various investigations and concerning research reports reveal that although a Pesticides Act exists to safeguard consumer interest, there is no MRL (Maximum Residue Level) in place or regulations to enforce it. Nearly every food item from rice to veggies and fruits available in the market are contaminated with poisonous pesticides, authorities caution. Pesticides and insecticides could be detrimental to people’s immune and reproductive systems. It can even lead to infertility. Developmental toxins’ in these chemicals may adversely affect the development in children. They may also act as endocrine disrupters, leading to hormonal imbalances. These chemicals are also not biodegradable(able to decompose naturally). As such, they persist for a long time and get transferred into the food chain. This means that overtime, they get deposited in the human body.
ABOUT AUTHOR: Amit Gangwal
Department of Pharmacognosy,
Smriti college of pharmaceutical education, Indore, Madhya Pradesh, India gangwal.amit@gmail.com
ABSTRACT
Patents provide an incentive to the pharmaceutical industry to invest in the development of new medicines to treat diseases that are currently untreatable or incurable, and provide options when patients develop resistance to older drugs. Around the world it has been a challenge for last one or two decades to innovate concepts and mechanisms to hasten the drug development schemes/process, while augmenting dereplication ways in a full proof manner to save time, man power and financial input. High failure rate at any stage in drug development process is bothering and evoking various tools to be discussed like never before. The pharmaceutical industries world over, are in a period of crisis due to the poor number of approved drug molecules relative to the high levels of R&D investment. The drug industry is facing major scientific and strategic challenges. Moreover competition from generic giants is giving tough challenge to established products owing to end of patent rights. The concerns are further aggravated by couple of decisions announced by Indian courts (Nexavar® followed by long time pending battle of Gleevac®). These two decrees by Indian courts were not ruled in the favor of pharma giants; Bayer and Novartis respectively. Millions are dying in various part of world, owing to their inability to purchase the Elite Drugs, because of intellectual property rights. In this article various pros and cons have been discussed pertaining to generic medicines and patent fights of innovators world over.
About Authors: Kuntal Pal1, Sampat Kumar Kundu2 1Faculty of Ayurveda, Institute of Medical Sciences, Rajiv Gandhi South Campus,
Banaras Hindu University, Barkachha, Mirzapur-231001 2Gurunanak Institute of Pharmaceutical Science & Technology
Sodepur, West Bengal. sampatkundu001@gmail.com
Abstract
World is running so first, at this moment medicines have to work to maintain the health of the people to give them power to stabilize them. Modern medicine is working from a decades or so, but many traditional systems of medicines also show some beneficial effects in that era. Likewise Kampo, Traditional Chinese Medicine(TCM), Ayurveda & Herbal Medicines. Those kind of medicines can give a patient resistant to protect the disease without less side effects. Pistia stratiotes is a plant which plays a commendable role in that era. It is used in different kind of disease which are described in this mini review.
About Authors: 1*Neeraj Kumar Lohani, 2Vachaspati Mishra, 3Divakar Joshi 1,2Department of Biotechnology, Institute of Biomedical Education and Research, Mangalayatan University, Beswan, Aligarh-Uttar Pradesh, india, 3MBPG College Haldwani Nainital Kumaun University Nainital Uttarakhand. neerajlohani06@gmail.com
Abstract
The interdisciplinary approach with nanotechnology and animal tissue culture technique is going to revolutionize biomedical science in the next fifty years. Nanotechnology along with regulated animal tissue culture, makes tissue engineering a realization based on the creation of new tissues in vitro followed by surgical placement in the body or the stimulation of normal repair in situ using bio-artificial constructs or implants of living cells introduced in or near the area of damage at nano level.It makes use of artificially stimulated cell proliferation by using suitable nano-material based scaffolds and growth factors. Nanotechnology can be successfully used to create a tissue or organ that can take the place of one that is terminally diseased, such as an eye, ear, heart, or joint. Implantable prosthetic devices and nano scaffolds are used for growing of artificial organs. The key components of tissue engineering with nanotechnology include: cells, scaffolds, signals and bioreactors. Scaffolds are produced by electro-spinning technique.The scaffold acts as an interim synthetic extra cellular matrix (ECM) that cells interact with prior to forming a new tissue.
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