A REVIEW ON ANALYTICAL METHODS FOR IVABRADINE DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS

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UV Spectroscopic Method
First order derivative spectroscopy and Area Under the curve spectroscopic technique was developed for simultaneous determination of Ivabradine was developed

Table no 2. Summary of Spectroscopic methods for Ivabradine



Sr.No


Title


Method


Wavelength


Linearity (ug/ml) and R2

 


Recovery

 


Ref


1


Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of Ivabradine controlled release formulations.


UV


286 nm


5-60 μg/ml

0.9998


-----


Panda et al., 2014


 

 2


 Q-absorbance ratio spectrophotometric method for simultaneous determination of atenolol and ivabradine hydrochloride in synthetic mixture


Q-absorbance ratio


286.04 nm and 276 nm


2-10 μg/ml

0.998


100.47 ± 0.348

 


Patil et al., 2016

DISCUSSION
The presented systematic review covers the current analytical methods for the determination of Ivabradine and its combination in pharmaceutical and biological samples like serum and plasma. HPLC method were found to be most widely use for Ivabradine. Various chromatographic conditions are presented in table.

CONCLUSION
The sensitivity, specificity, and better separation efficiency enable HPLC to be used frequently for simultaneous qualitative and quantitative determination of Ivabradine. The presented information is useful for the future study for researcher involved in formulation development and quality control of Ivabradine.

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