Skip to main content

Articles

 

Clinical courses

  • CORTICOSTEROIDS USE IN PREGNANCY

    About Authors:
    Patel Brilina M*, Yadav Nisha D, Maheta Payal, Arora Bhoomi
    Institute of clinical research India,
    Ahmedabad,
    Gujarat, India
    *patelbrilina@gmail.com

    Abstract:
    Corticosteroids, often referred to as steroid medications, contain man-made versions of the hormone cortisol. Corticosteroids are mainly used to relieve inflammation. Inflammation occurs when the immune system causes part of the body to become swollen, red and filled with fluid in response to an infection. The immune system is the body’s natural defence against infection and illness. Steroids form an important component in pregnancy to reduce the inflammation and are used since very long time for different conditions in different forms. Though very few molecules are used since very long time. Now increase knowledge in uses of corticosteroids in pregnant women who suffer from asthma, skin diseases, rheumatoid arthritis etc.

    (adsbygoogle = window.adsbygoogle || []).push({});
  • Formulation and evaluation of herbal ointment for wound healing and anti marking activity by using Vitis venifera and Annona reticulata seeds extracts

    About author:
    Gowthami Royal,
    Mother Theresa institute, Tirupati
    gowthamiroyalp@gmail.com

    Abstract:
    The main aim of the present study was to evaluate the two activities that are anti marking and wound healing activities by Ethanolic extracts of Annona reticulata and Vitis venifera with combination of honey , ghee and neem oil. The both Annona reticulata (custard apple) and Vitis venifera (grapes) are well known plants in Indian traditional medicine. According to the literature reference and Indian traditional use, both Vitus andAnnona were selected for evaluation of wound healing potentiality and anti marking capability. Phyto chemical studies revealed Ethanolic extract of Annona seeds have alkaloids, phytosterol, fixed oil, fats, phenolic compounds, tannins, proteins, amino acids and flavonoids. The studies revealed in case of grape seed extract which is having Linoleic acid, Oleic acid and Palmitic acid. Ethanolic extract of seeds of Annona reticulata and grape seed extract with other ingredients were examined for the activity in the form of ointment in wound models on rat. These formulations for test showed adequate response as compared to standard drug in terms of healing time, marks and tensile growth.

  • LIPOSOME NOVEL DRUG DELIVERY SYSTEM

    About Authors:
    Dr.Pushpendra Kumar Tripathi(director of RITM(pharmacy), *Shipra srivastava
    Rameshwaram  Institute Of Technology And Management
    Lucknow.
    *shipra.hanny1987@gmail.com

    Abstract:
    The goal of any drug delivery system is spatial placement and temporal delivery of the medicament. Research works are going on to prepare an ideal drug delivery system which satisfies these needs. Researches carried out by ALEC BINGHAM lead to the development of a new drug delivery system called as liposome. Liposomes are small vesicles (_100 nm) composed of various of lipid molecules which build their membrane bilayers. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers . Liposomes are biodegradable and biocompatible in nature.

  • Effect of Oscimum Basilicum on Formulation and Evaluation of Rapid Disintegrating Tablet of Lamotrigine

    About Authors:
    SHARMA AKANSHA*, AGRAWAL SHIKHA
    SWAMI VIVEKANAND COLLEGE OF PHARMACY
    KHANDWA ROAD INDORE (M.P.)
    *akansha.sharma@mylan.in

    ABSTRACT :
    The main aim for performing this project is to increase the bioavailabilty of lamotrigine as well as its onset of action to control the seizures that occur during the epileptic attack. To serve this purpose we will use mucilage of oscimum basilicum as a natural superdisintegrant & later comparing it with different novel synthetic superdisintegrant. By preparing a rapid disintegrating tablet of lamotrigine, rapid action of same can be achieved easily.
    As we know that superdisintegrant plays the major role in rapid disintegration of tablet, thus it is very important to select a right or correct superdisintegrant in all respect which fulfill its purpose without effecting other parameters of tablet formulation and gives quicker and better result, when the number of formulation with different combinations of superdisintegrants (Natural & Synthetic) will be made then it would become very easy to evaluate and get the formulation with maximum desirable results.Lamotrigine being a poorly water soluble drug, needs modification to make them water soluble.

  • Formulation and Evaluation of Fast Dissolving Tablets of Metoclopramide Hydrochloride Using Natural sweetening agent of Stevia Leaf Powder.

    About Authors:
    Savita bhati*, Vandana Sethi
    Lloyd Institute of Management & Technology.
    Plot No.-11, Knowledge Park-II,
    Greater Noida, U.P.
    *savitabhati1987@gmail.com

    Abstract:
    Taste masking becomes a pre-requisite for bitter drugs to improve the patient compliance especially in the pediatric and geriatric population. Metoclopramide hydrochloride is recommended in dose of 10 to 15 mg four times a day for getting relief from nausea, vomiting, stomach pain and reflux oesophagitis. It finds application in all the categories of patients.In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Metoclopramide Hydrochloride using stevia leaf powder as a taste masking agent. Direct compression was the technique used for preparing taste masked tablets.

  • SUPERPOROUS HYDROGEL: A SUPREME APPROACH FOR GASTRIC RETENTION

    About Authors:
    Jigar Modi*1, Dr. Jayvadan Patel1, Dr. Hitesh chavda2

    1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
    Kamana Crossing, Visnagar-384 315,
    Dist – Mehsana, Gujarat, India.
    2Shri Sarvajanik Pharmacy College,
    Nr. Arvind Baug, Mehsana, Gujarat, India
    *jigo_farmacy@yahoo.com

    ABSTRACT:
    Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

    (adsbygoogle = window.adsbygoogle || []).push({});
  • A FORMULATION AND DEVELOPMENT OF ORODISPERSIBLE TABLET OF LORNOXICAM

    About Authors:
    Mr.Sanjay wasudeo upare*, Dr.A.V.Chandewar, Dr.M.D.Kshirsagar, Mr.U.S.Koli and Mr.H.K.Pokale
    M-Pharm IV semester (Pharmaceutics department)
    Pataldhamal Wadhwani college of Pharmacy,
    Yavatmal

    *uparesanju81@gmail.com

    ABSTRACT:
    Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties. The purpose of this study was to develop a taste masked oral disintegrating tablet of poorly soluble Lornoxicam by direct compression technique with β-cyclodextrin (BCD) complexes using various super disintegrants like sodium starch glycolate, crospovidone and L-Hpc. Prepared tablets were evaluated for different properties like drug content, hardness, friability, disintegration time and in vitro dissolution study. The different formulations showed disintegration time between 21 to 33.66 s. Drug release showed time between the ranges of 5 to 30 min. Among all the formulations, L1 showed 97.79% drug release within 30 min. Thus, L1 was considered best among the other formulations.. The tablets showed enhanced dissolution hence better patient compliance.

  • MONOCLONAL ANTIBODIES : A REVIEW

    About authors:
    1.Shashi Kant*, Satinder Kumar,
    Research scholar department of pharmacy.
    2. Dr. Bharat Prashar
    HOD & Associate professor 
    Department of Pharmaceutical Sciences,
    Manav Bharti University, Solan (H.P)

    shashi_ranaute@yahoo.in

    ABSTRACT :
    In this review article we discussed about are monospecific identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular the non-proprietary drug name ends in mabs,in this we discussed type of monoclonal antibodies,preparation,targeting of monoclonal antibodies as well as advantages and disadvantages of monoclonal antibodies. antibodies that are biology and medicine.

  • REVIEW ARTICLE : ANTIAGING COSMETICS

    About Authors:
    Joshi B.*, Agarwal P., Sahu D., Dashora A.
    Geetanjali Institute of Pharmacy,
    Udaipur Rajasthan, India

    *bhavesh.joshi8@gmail.com

    Abstract:
    Antiaging is emerging class of cosmetics which combine the benefit of anti aging ingredients with the elegance skin feel and delivery system of cosmetics antioxidants, anti cellulites and anti microbial have been use in maintaining and enhancing human beauty. Anti aging ingredients also help to reduce the fine lines, increasing the moisture level and reduces wrinkles and puffness to keep the skin in good condition. New delivery system is a more effective solution for the skin aging resulting from photoaging. New vehicle like liposome and nanoparticles is a new generation for antioxidants with enhanced bioavailability and very stable activity. Our objective is to review present state of the art knowledge pertaining to mechanisms involved in skin aging, factor responsible for aging and various new ingredients use to treat aging defect.

  • EVALUATION OF ANTI-STRESS (ADAPTOGENIC) ACTIVITY OF LUFFA CYLINDRCIA FRUIT EXTRACT

    About Authors:
    Sachin Kaushik*, Dr. shivakumar Hugar
    P.G. Department of Pharmacology,
    B.L.D.E.A.’s college of Pharmacy,
    Bijapur- 586103,
    Karnataka,India
    *sachin_2004_kaushik@yahoo.com

    ABSTRACT:
    In the present study antistress activity was assessed against anoxia tolerance, swimming endurance and cold restraint stress models. In anoxia tolerance test, the mean time of appearing first convulsion in mice was taken as end point to determine the time of anoxia.  In swimming endurance test the mean time of swimming performance was recorded.The end point taken was when the animals remained at the bottom of swimming tank for 10 sec. Biochemical estimation like glucose, cholesterol, triglycerides and BUN and weight of organs were measured in cold restraint stress model.

Subscribe to Articles