FORMULATION AND CHARACTERIZATION OF MICROEMULSION BASED GEL OF ANTIFUNGAL DRUG

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About Authors:
Patel Rahul R.*, Dr Kanu R Patel, Dr Mukesh R Patel
Department of Pharmaceutics,
Shri B.M.Shah College of Pharmaceutical Education and Research
Dhansura Road College campus Modasa,
Dist:- Arvali. Pin code:- 383315 Gujarat, (india)
rahulrpatel21089@yahoo.com

Abstract
Micro emulsion based Gel formulation provides better application property and stability & makes it dual control release system in comparison to cream and ointment. Topical Microemulsion based gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation an Microemulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. Whenever, it is used for fungal disease for topical delivery system soit is good for compare to oral delivery. When gels and Micro emulsions are used in combined form the dosage form are referred as Microemulsion based gel. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. It is prepared by mixing an oil-in-water type or water-in-oil type emulsion with a gelling agent.The use of Micro emulsion based gels can be extended in analgesics and antifungal drugs.

REFERENCE ID: PHARMATUTOR-ART-2101

PharmaTutor (ISSN: 2347 - 7881)

Volume 2, Issue 2

Received On: 29/012/2014; Accepted On: 05/01/2014; Published On: 10/02/2014

How to cite this article: RR Patel, KR Patel, MR Patel, Formulation and Characterization of Microemulsion based Gel of Antifungal Drug, PharmaTutor, 2014, 2(2), 79-89

Introduction
Topical delivery used for many types of category via skin like as i.e. Antifungals, Non steroidal anti inflammatory drug, Antiviral, Antiacne, etc. Human skin is well-organized membrane. i.e. Stratum corneum, the outermost layer of epidermis is formed by dead and keratinized cells. And it is an excellent barrier to penetration of drugs through the skin.[1]

Introduction of Topical Drug Delivery System
Topical delivery administration is a localized drug delivery system anywhere in the body through opthalamic, rectal, vaginal, and skin as topical routes. Efforts to cure diseases have been leading in the discovery of various drugs, medicine and delivery systems. Route of administration depends on type and severity of disease. For skin disorders topical route is most preferred. Topical drug delivery system can be defined as direct application of formulation containing medication to the skin to get localized effect of drug.

Topical drug delivery system has several advantageous such as ability to deliver drug more selectivity to specific site. Most and favourable reason for using topical delivery is avoidance of gastro-intestinal incompatibility and metabolic degradation associate with oral administration. Moreover, topical delivery provides an increased bio-availability by avoiding first pass metabolism by liver and a consistent delivery for extended period. The release rates of drugs from topical preparation depend directly on the physiochemical properties of the carrier and the drug employed.[2]

Gel is semisolid system of at least two interpenetrating phases: a gelling agent and a liquid. When gel and microemulsion are used in combined form and the dosage forms are referred as microemulsion based gel. Microemulsion based gels have emerged as one of the most intresting topical drug delivery system as it has dual control release system i.e gel and microemulsion. The microemulsion based gel for dermatological use has several favourable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, water-soluble, longer shelf life, bio- friendly, transport, and pleasing appearance, transparent, etc Microemulsions have gained a great attention for delivery of hydrophobic agents for systemic and local treatment. Also, gels are a relatively newer class of dosage form created by entrapment of large amounts of aqueous or hydro alcoholic liquid in a network of colloidal solid particles. Which may be consist of inorganic substances such as aluminium salts, organic polymers of natural and synthetic origin.[3]

In recent years, there has been great interest in the use of novel polymers with complex functions as emulsifiers and thickness because the gelling capacity of three compounds allows the formulation of stable microemulsions and opposite creams are decreasing surface and interfacial tension and at the same increasing the viscosity of the aqueous the water phase converts a classical microemulsion into an microemulsion based gel.

For topical delivery semisolid preparation are widely accepted over solid and liquid dosage forms. Microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and co-surfactant, can be used as drug delivery system because of their capacity to solubilise poorly water-soluble drugs as well as their enhancement of topical. For topical delivery microemulsion is incorporated in to gel base to prolong the local contact to the skin.[4]

Advantages of Topical Drug Delivery System. [5,6]

  • Avoidance of first pass metabolism.
  • Avoidance of gastrointestinal incompatibility.
  • More selective to a specific site (local action).
  • Ketoconazole microemulsion based gel directly penetrate in to specific site where is it suffering from fungal disease and start to results in inhibition of ergosterol synthesis.
  • Suitability of drug with short half life and potent drug.
  • Suitability also for self medication. Ability to easily terminate medication when needed narrow therapeutic window.
  • Most and potent advantageous is that type microemulsion gel has shown low particle size so it can be easily to absorb drug through skin also permeability have be shown high.
  • Improve patient compliance.
  • Higher dose can be acceptable for topical drug delivery system

Disadvantages of Topical Drug Delivery System. [7]

  • Skin irritation of dermatitis may occur due to the drug or excipients.
  • Possibility of allergic reactions.
  • Main limitations of microemulsion based gel that remains are poor absorption of microparticle via skin and entrapment of bubble during formulation.
  • Some drugs of larger particle size not easy to absorb through the skin.
  • Poor permeability of some drugs through skin.

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