Telangana

Osmania University established in 1918, is the seventh oldest in the Country, third oldest in South India and the First in the princely state of Hyderabad. The establishment of Osmania University symbolizes a renaissance in the Indian Educational System and has shown a remarkable resilience throughout its existence. The university is instrumental in propagation of Higher Education to cater the needs of community in the region over nine decades and has grown into one of the major Universities of India. It has a vast sprawling green campus of 500 hectares set in picturesque and idyllic surroundings. It owns number of buildings of great architectural elegance and variety to enhance the beauty of the campus. The university is an autonomous institution created through an act of legislature and most part of funding is from the State Government. The university holds the flagship for Higher Education of Government of Andhra Pradesh and has played a key role in planning, initiating and implementation of various development programs.

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ABOUT AUTHORS:
Kavitha Reddy Jupally*, A.Pavani, R. Raja Reddy, Habibuddin.
Department of Pharmaceutics, Malla Reddy Pharmacy College,
Maisammaguda (via- Hakimpet), secunderabad, Telangana, India.
kavithareddy0811@gmail.com

ABSTRACT
Ramipril is a prodrug belonging to the class of angiotensin-converting enzyme (ACE) inhibitor, which undergoes extensive hepatic first pass metabolism. The aim of the present study is to develop buccoadhesive bilayered tablet of ramipril  to achieve the greater therapeutic efficacy, to increase the bioavailability, to overcome the first pass hepatic metabolism of the drug. A UV spectrophotometric method has been employed for the estimation of Ramipril at 219 nm. Buccal tablets of Ramipril were prepared by direct compression method using ethyl cellulose as a polymer. The precompression parameters like bulk density, tapped density, carr’s index and angle of repose were determined. The post compression parameters like hardness, thickness, friability, weight variation, in vitro dissolution, FTIR studies were carried out to check if any interactions had occurred, results were promising. The optimized formulation was selected based on results and percentage drug release was found to be 92.95 and followed First order, peppas model with Fickian release mechanism.

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ABOUT AUTHORS
Balay Ragini*, A.Pavani, R.Raja Reddy
Malla Reddy Pharmacy College,
Maisammaguda(via-hakimpet), Secunderabad, Telengana. india
ragini.balay@gmail.com

ABSTRACT
Cefuroxime Axetil is a second generation antibacterial belongs to Cephalosporin Group. The drug undergoes rapid metabolism in intestinal mucosa due to change in pH Environment and hence has decreased oral bioavailability. The aim of present investigation is to increase the gastric residence time by preparing gastroretentive tablets here by improving bioavailability of Cefuroxime Axetil. A simple UV spectrophotometric method has been employed for the estimation of Cefuroxime Axetil at 281 nm. A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, sodium alginate and hydrocolloids like hydroxyl propyl methyl cellulose (HPMC) and guggul. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, In vitro release, buoyancy lag-time and swelling index. The formulations were optimized for the different grades of HPMC, and its concentrations and combinations. The results of the In vitro release studies showed that the optimized formulation F3 could sustain drug release of 92% and remain buoyant for 10h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominately Higuhci with non fickian diffusion. Finally the tablets formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.

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ECHS invites applications to engage following Staff on contractual basis in ECHS Polyclinics in Telangana & Andhra pradesh for a Period of one year, renewable for additional period:

Post: Pharmacist

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ABOUT AUTHORS
Goundla Uday Bhasker Goud¹*, Jakkampudi Sri Venu Prakash¹, Avadhanam Pranav Kumar², Gangi Reddy Sreenivas Reddy², Manikanta Sai Krishna².
¹Department of Industrial Pharmacy
²Department of Pharmaceutics
Bharat Institute Of Technology, Mangalpally, Hyd, Telangana, India.
gouds.uday04@gmail.com

ABSTRACT
Aim: The current paper was an attempt to design a extended release dosage form of Metformin hydrochloride using various grades of hydrophilic polymers, hydroxy propyl methyl cellulose (HPMC K4M, HPMC K15M, HPMC K100M and HPMC K200M) and MCC.
Materials and Methods: Laboratory scale batches of 4 tablet formulations were prepared by wet granulation technique. Precompression parameters of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in-vitro release pattern for 12 hr using Phosphate buffer of pH 6.8 at 37 ± 0.5°C.
Results and Discussion: The results obtained revealed that HPMC K100M in formulation (F3) was able to sustain the drug release for 12 h and followed the Higuchi pattern quasi-Fickian diffusion. and charged for stability testing, parameters were within the limit of acceptance. There was no chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR).
Conclusion: Hence it can be concluded that formulation F3 containing HPMC K100M is suitable for development of extended release tablets of Metformin Hydrochloride.

Post: Assistant Drugs Controller(India)

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No.of post: 10, UR-04, OBC-01, SC-04, ST-01

Eligible candidates are invited to attend WALK - IN - INTERVIEW on the following date at 9.30 a.m. sharp for the following positions on the ad hoc research project entitled “Vitamin A metabolic pathway on region – specific adipose tissue development and its relevance to insulin resistance: A proteomic approach to sexual dimorphism”. The essential qualification, experience, consolidated Fellowship and service tenure are as under: The project is funded by DBT.

Post: Junior Research Fellow- 02 nos.

The University of Hyderabad (UoH), one of the major institutions of higher education in India is largely devoted to postgraduate studies and is widely known for its excellence in research and for its distinguished faculty. Founded in 1974 with Prof. Gurbaksh Singh as its first Vice Chancellor, UoH - also known as Hyderabad Central University or HCU- has emerged as a leading centre of teaching and research. The large campus located near Gachibowli, which is the IT hub of Hyderabad, has immense bio-diversity and is home to over 75 varieties of bird, not to speak of the lakes and rock formations which give the campus a natural beauty.

Applications are invited from the eligible candidates (Indian Nationals only) on a plain paper for the following temporary posts in the research projects sponsored by DBT, New Delhi.

Post: Technical Assistant, Project Assistant

Nalanda College of Pharmacy (NCOP) was established in the year 1995 and is currently running different courses in Pharmacy ranging from Diploma to Post Graduation. NCOP is known for providing quality education in Pharmacy and recognized as the best college in the region.In the field of research, NCOP has created history in undertaking various useful research projects and published record number of research papers in the renowned journals around the globel. NCOP has also secured AICTE-MODROB and AICTE-RPS schemes for 2013-14 academic session.

Post: Professors / Associate Professor / Assistant Professor / Lecturers