Shri Guru Ram Rai Institute of Technology & Sciences

EMERGENCE OF NOVEL PEPTIDE MOLECULAR CLASS AS ANTIBIOTICS

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ABOUT AUTHORS
Akansha Bhandari1, Nitisha Bhandari2*
1
Department of Lifesciences,
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, India
2 Department of Biotechnology, Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Modern era diseases bring more challenges and hurdles to the rational drug targeting. However chemotherapy is the most affected area as most reports are related to antibiotics resistance. Although some successes are accounted as new molecules and new structures are keep on synthesizing or either isolated. One such example is Teixobactin which is isolated for Eleftheria terrae, which was found to be active against Staphylococcus and Mycobacterium bacteria. The story of Teixobactin isolation could open new horizon and opportunistic ways for future designing of useful drugs against these resistance bacteria. In the similar context we tried to compile the relevant paper that was published in nature in 2015 into a commentary based critical review.

BIOLOGICAL FUNCTIONS OF VITAMIN B COMPLEX AND EFFECTS ON HUMAN HEALTH IN BOTH EXCESS AND DEFICIENCY LEVELS

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ABOUT AUTHORS:
Amarjeet Kaur
Department of Pharmacy,
Guru Ram Das (PG) Institute of Management & Technology,
Dehradun, Uttarakhand, 248009, India.
amarjeetkaur069@gmail.com

ABSTRACT:
Vitamins are micronutrients and play vital role in healthy life. Body needs them in relatively small amounts, in comparison with other nutrients. Vitamins are two types on bases of their solubility viz. lipid soluble and water soluble. B vitamins or vitamin B complex are a group of water-soluble vitamins that play important roles in cell metabolism. These vitamins are chemically distinct vitamins that often coexist in the same foods. Individual B vitamin supplements are referred to by the specific name of each vitamin (e.g., B1, B2, B3, B5, B6, B7, B8, B9, B12 etc.). In general, supplements containing all eight vitamins are referred to as a vitamin B complex. B vitamins are found in whole unprocessed foods. Processed carbohydrates such as sugar and white flour tend to have a lower B vitamin than their unprocessed counterparts. Good sources for B vitamins include legumes (pulses or beans), whole grains, potatoes, banana, chilli peppers, tempeh, nutritional yeast, brewer’s yeast, and molasses. The vitamin B12 is of note because it is not available from plant products, making B12 deficiency a legitimate concern for vegetarians. Deficiency of B vitamins causes various diseases. Their deficiency may cause diseases viz.Vit. B1-Beriberi; Vit B2-Ariboflavinosis; Vit B3-Pellagra; Vit B5-acne; Vit B6-microcytic anaemia; Vit B7-CNS disorders; Vit B9–leucopaenia, macrocytic anaemia; Vit. B12­-Macrocytic anaemia, memory loss.

International Conference on Present Trends & Future Prospects in Pharmaceutical Sciences at Shri Guru Ram Rai Institute of Technology & Science | February 14-15, 2014

Shri Guru Ram Rai Institute of Technology & Science was established in 1994 at Dehradun by Shri Guru Ram Rai Education Mission with the financial support of its parent body - Darbar Shri Guru Ram Rai JI Maharaj, a 361 year old religious and philantropic organization.
The Mission has a track record of commendable service of over five decades in providing modern education at reasonably low cost. easily affordable by middle class segment of the society. As on date, it runs 120 educational institutions in North India - a Postgraduate College, Inter-mediate Colleges affiliated with Uttarakhand Board of Education and Examination and English Medium Public Schools on CBSE pattern. In the Postgraduate and Inter-mediate Colleges free education is provided to the students and the fee in Public Schools is reasonably low.

TO STUDY THE EFFICACY AND EFFECTS ON LIPID METABOLISM, ANTHROPOMETRY AND BLOOD PRESSURE OF COMBINATION TREATMENT WITH ARB+HCTZ AND ACES+HCTZ IN HYPERTENSIVE PATIENT

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About Authors:
Rajak Sandeep1, Kothiyal Preeti2, Mathur Prashant1
1Department of clinical pharmacy,
2Department of pharmacology,
Division of Pharmaceutical sciences,
Shri Guru Ram Rai Institute of Technology And Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, India
sandeep.rajak1886@gmail.com

Abstract
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are widely prescribed for the treatment of hypertension and heart failure, as well as for kidney disease prevention in patients with diabetes mellitus and the management of patients after myocardial infarction.Both combination therapies of an Angiotensin II receptor blocker (ARB) with the thiazide hydrochlorothiazide (HCTZ) and an Angiotensin converting enzymes (ACEs) with HCTZ are recommended to achieve blood pressure (BP) goals in antihypertensive treatment. However, although HCTZ is known to have unfavorable effects on lipid metabolism, the effects of HCTZ in the ARB+HCTZ and ACEs+HCTZ combination on lipid metabolism have not been fully elucidated. The objective of present study was “To study the Efficacy and Effects on Lipid Metabolism, anthropometry and blood pressure of Combination Treatment With ARB+HCTZ and ACEs+HCTZ in hypertensive patient.”

All prescription of hypertensive patients coming to the medicine OPD and IPD would be screened and those prescribed with  ACE-inhibitors+HCTZ and ARBs+HCTZ combination of  drugs will be selected for this study.

COMPARATIVE STUDY ON PROPHYLACTIC USE OF AMOXICILLIN AND CLAVULANIC ACID IN COMBINATION VS CEFTRIAXONE IN NEUROSURGERY WARD OF A TERTIARY CARE HOSPITAL WITH ASSESSMENT OF RESISTANCE RATE IN NEUROSURGERY TO ANTIMICROBIALS

ABOUT AUTHORS:
Neehar Dixit, Arun Kumar, Prashant mathur, Preeti kothiyal
Department of clinical pharmacy
Division of Pharmaceutics
SGRRITS, Patel Nagar
Dehradun, 248001
Uttarakhand, India
neehar.dixit007@gmail.com

ABSTRACT
Antimicrobial agents are among the most commonly prescribed drugs and account for 20% of the hospital pharmacy budget. The present study was designed to observe and compare the prophylactic use of antibiotics (amoxicillin+clavulanic acid vs ceftriaxone) in neurosurgery ward of a tertiary care hospital with assessment of resistance rate in neurosurgery to antimicrobials. Total no of 250 patients were included in the study, in this study inclusion of 232 patients  were receiving amoxicillin+clavulanic acid or Ceftriaxone for prophylaxis in neurosugery. The following parameters were included- reduction of fever, reduction of exudates, depression or disappearance of pathogenic bacteria, overall clinical improvement, complications and length of hospitalization stay. Test of significance of two real ratios was applied and the value of Z indicated (Z=36) which is highly significant hence two ratios are not equal. It implied that ceftriaxone was better than amoxicillin+clavulanic acid. Present study conclude that the resistance rate of penicillins is higher than ceftriaxone in neurosurgery ward. Data  also shows that ceftriaxone is the better choice of treatment and it reduces the hospitalization stay of patients and lead to less burden on patient.

THYROID DYSFUNCTIONS AND ITS MONITORING

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About Authors:
Pathak Namita*, Kothiyal Preeti, Dr. Prashant Mathur
Department of Clinical Pharmacy,
Shri Guru Ram Rai Institute of Technology and Sciences,
Dehradun, Uttarakhand, India, 248001
pathak_namita@ymail.com

Abstract
The prevalence of hypothyroidism is three times higher among women than men. The prevalence in an unselect­ed community population of young, middle aged and elderly individuals is about 1.4 percent and the estimated annual incidence rate is one to two per 1,000 women. Surveys of geriatric populations have yielded estimated prevalence rates for overt hypothyroidism of 0.2 percent to 3 percent. The presentation of symptoms in the elderly may be atypical or absent. The prevalence of subclinical hypothyroidism is estimated to be between 4.0–8.5% of the adult US population without known thyroid disease, and the prevalence increases with age. Up to 20% of women over the age of 60 are estimated to have subclinical hypothyroidism. Caucasians are more likely to have subclinical hypothyroidism than non-Caucasians. The risk is highest in those with type I diabetes mellitus, a family history of thyroid disease or head/neck cancers treated with external beam radiation. Other risk factors include previous radioactive iodine treatment or thyroid surgery. Interestingly, about 20% of patients on thyroid medications are both over re­placed and under replaced. Because of the high incidence of thyroid disease, The American Thyroid Association recommends measuring thyroid function on all adults beginning at age 35 years and every 5 years thereafter noting that more frequent screening may be appropriate in high risk groups. The treatment of subclinical hypothyroidism has been controversial but more recent data suggest there are increased risks of ischemic heart disease in untreated patients and that a more aggressive approach to treat­ ment would be appropriate.7 In contrast, subclinical hyperthyroidism has more well understood risks of atrial fibrillation and flutter and so should be more ag­gressively treated.

BRAIN DRUG DELIVERY OF NANOPARTICLES BY NASAL ROUTE FOR THE TREATMENT OF DEPRESSION

ABOUT AUTHORS:
Rakhi Choudhary*, Lakshmi Goswami , Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand , India
rakhichaudhary211@gmail.com

ABSTRACT
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.

ADDITIVES IN PHARMACEUTICAL GELS: A REVIEW

ABOUT AUTHORS:
Bhatt Preeti *, Gnanaranjan. G , kothiyal Preeti
Department of pharmaceutics,
Shri Guru Ram Rai Institute Of Pharmacy,
Dehradun-248001, India
*preetibhatt03@gmail.com

ABSTRACT
The motto of writing this review on additives in pharmaceutical gel was to compile the recent literature with special focus on rational approach to topical formulation and basic components used in gel for topical drug delivery systems. Topical drug delivery systems involve the introduction of a drug to the surface of the body, in a formulation which can be absorbed. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action as they show better potential as a vehicle to administered drug topically in comparison to ointment. Additives are inactive ingredients used for structuring dosage form. Selection of topical vehicles depends on various dermatological factors and pharmaceutical factors. Dermatological factors are absorption penetration, skin condition, compatibility, emollient properties. Pharmaceutical factors are stability, solvent properties, emulsifying property.  The choice of suitable exepient for a formulation development is made on the basis of the drug delivery requirements and the particular need to impart sufficient emolliency or other quasi-medicinal qualities in the formulation.

REVIEW ON BETA- CYCLODEXTRIN INCLUSION COMPLEX: A MORDEN APPROACH FOR DRUG DELIVERY

ABOUT AUTHORS:
Bhatt Anjali*, Goshwami Lakshmi,  Papola Vibhooti, Pathak Namita, Rawat Shuveksha
Shri Guru Ram Rai Institute of Technology and Science,
Dehradun 248001, Uttrakhand India
*anjali23mar@gmail.com

ABSTRACT
Cyclodextrins were first described by Villiers in 1891. Schardinger laid the foundation of the cyclodextrin chemistry in 1903 and identified cyclodextrin. In the 1930s, Freudenberg identified cyclodextrin and suggested that larger cyclodextrins could exist. Freudenberg and co-workers showed that cyclodextrins were cyclic oligosaccharides formed by glucose units and somewhat later Cramer and co-workers described their ability to form inclusion complexes. By the early 1950s the basic physicochemical characteristics of cyclodextrins had been discovered, including their ability to solubilize and stabilize drugs. The first cyclodextrin-related patent was issued in 1953 to Freudenberg, Cramer and Plieninger. However, pure cyclodextrins that were suitable for pharmaceutical applications did not come available until about 25 years later and at the same time the first cyclodextrin-containing pharmaceutical product was marketed in Japan. Later cyclodextrin-containing products appeared on the European market and in 1997 also in the US. This review aims to assess the use of cyclodextrin in newer drug delivery system such as nanosponges, nanoparticles, nanospheres, liposomes and other drug delivery system.

CURRENT AND FUTURE TREND IN NANOTECHNOLOGY: A REVIEW

ABOUT AUTHORS:
Anjali* , Lakshmi Goswami, Dr. Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology and Sciences
Patel nagar, Dehradun
anjali23mar@gmail.com

ABSTRACT
In field of nanotechnology nonmaterial are at the leading edge. Nanotechnology has received a lot of attention with enthusiasm because of its future potential. Their unique size-dependent properties make these materials greater and indispensable in many areas of human activity. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. This brief review tries to summarise the most recent developments in the field of applied nanomaterials, nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions, in particular their application in biology and medicine, and discusses their commercialisation prospect.

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