Shri Guru Ram Rai Institute of Technology & Sciences

16 March 2016

EMERGENCE OF NOVEL PEPTIDE MOLECULAR CLASS AS ANTIBIOTICS

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ABOUT AUTHORS
Akansha Bhandari¹, Nitisha Bhandari^2*

1Department of Lifesciences,
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, India
² Department of Biotechnology, Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Modern era diseases bring more challenges and hurdles to the rational drug targeting. However chemotherapy is the most affected area as most reports are related to antibiotics resistance. Although some successes are accounted as new molecules and new structures are keep on synthesizing or either isolated. One such example is Teixobactin which is isolated for Eleftheria terrae, which was found to be active against Staphylococcus and Mycobacterium bacteria. The story of Teixobactin isolation could open new horizon and opportunistic ways for future designing of useful drugs against these resistance bacteria. In the similar context we tried to compile the relevant paper that was published in nature in 2015 into a commentary based critical review.
19 December 2013

International Conference on Present Trends & Future Prospects in Pharmaceutical Sciences at Shri Guru Ram Rai Institute of Technology & Science | February 14-15, 2014

Shri Guru Ram Rai Institute of Technology & Science was established in 1994 at Dehradun by Shri Guru Ram Rai Education Mission with the financial support of its parent body - Darbar Shri Guru Ram Rai JI Maharaj, a 361 year old religious and philantropic organization.
The Mission has a track record of commendable service of over five decades in providing modern education at reasonably low cost. easily affordable by middle class segment of the society. As on date, it runs 120 educational institutions in North India - a Postgraduate College, Inter-mediate Colleges affiliated with Uttarakhand Board of Education and Examination and English Medium Public Schools on CBSE pattern. In the Postgraduate and Inter-mediate Colleges free education is provided to the students and the fee in Public Schools is reasonably low.
16 December 2013

TO STUDY THE EFFICACY AND EFFECTS ON LIPID METABOLISM, ANTHROPOMETRY AND BLOOD PRESSURE OF COMBINATION TREATMENT WITH ARB+HCTZ AND ACES+HCTZ IN HYPERTENSIVE PATIENT

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About Authors:
Rajak Sandeep¹, Kothiyal Preeti², Mathur Prashant¹
¹Department of clinical pharmacy,
²Department of pharmacology,
Division of Pharmaceutical sciences,
Shri Guru Ram Rai Institute of Technology And Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, India
sandeep.rajak1886@gmail.com

Abstract
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are widely prescribed for the treatment of hypertension and heart failure, as well as for kidney disease prevention in patients with diabetes mellitus and the management of patients after myocardial infarction.Both combination therapies of an Angiotensin II receptor blocker (ARB) with the thiazide hydrochlorothiazide (HCTZ) and an Angiotensin converting enzymes (ACEs) with HCTZ are recommended to achieve blood pressure (BP) goals in antihypertensive treatment. However, although HCTZ is known to have unfavorable effects on lipid metabolism, the effects of HCTZ in the ARB+HCTZ and ACEs+HCTZ combination on lipid metabolism have not been fully elucidated. The objective of present study was To study the Efficacy and Effects on Lipid Metabolism, anthropometry and blood pressure of Combination Treatment With ARB+HCTZ and ACEs+HCTZ in hypertensive patient.

All prescription of hypertensive patients coming to the medicine OPD and IPD would be screened and those prescribed with ACE-inhibitors+HCTZ and ARBs+HCTZ combination of drugs will be selected for this study.
COMPARATIVE STUDY ON PROPHYLACTIC USE OF AMOXICILLIN AND CLAVULANIC ACID IN COMBINATION VS CEFTRIAXONE IN NEUROSURGERY WARD OF A TERTIARY CARE HOSPITAL WITH ASSESSMENT OF RESISTANCE RATE IN NEUROSURGERY TO ANTIMICROBIALS admin Mon, 11/11/2013 - 15:55
ABOUT AUTHORS:
Neehar Dixit, Arun Kumar, Prashant mathur, Preeti kothiyal
Department of clinical pharmacy
Division of Pharmaceutics
SGRRITS, Patel Nagar
Dehradun, 248001
Uttarakhand, India
neehar.dixit007@gmail.com

ABSTRACT
Antimicrobial agents are among the most commonly prescribed drugs and account for 20% of the hospital pharmacy budget. The present study was designed to observe and compare the prophylactic use of antibiotics (amoxicillin+clavulanic acid vs ceftriaxone) in neurosurgery ward of a tertiary care hospital with assessment of resistance rate in neurosurgery to antimicrobials. Total no of 250 patients were included in the study, in this study inclusion of 232 patients were receiving amoxicillin+clavulanic acid or Ceftriaxone for prophylaxis in neurosugery. The following parameters were included- reduction of fever, reduction of exudates, depression or disappearance of pathogenic bacteria, overall clinical improvement, complications and length of hospitalization stay. Test of significance of two real ratios was applied and the value of Z indicated (Z=36) which is highly significant hence two ratios are not equal. It implied that ceftriaxone was better than amoxicillin+clavulanic acid. Present study conclude that the resistance rate of penicillins is higher than ceftriaxone in neurosurgery ward. Data also shows that ceftriaxone is the better choice of treatment and it reduces the hospitalization stay of patients and lead to less burden on patient.
3 October 2013

BRAIN DRUG DELIVERY OF NANOPARTICLES BY NASAL ROUTE FOR THE TREATMENT OF DEPRESSION

ABOUT AUTHORS:
Rakhi Choudhary*, Lakshmi Goswami , Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand , India
rakhichaudhary211@gmail.com

ABSTRACT
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.
CURRENT AND FUTURE TREND IN NANOTECHNOLOGY: A REVIEW admin Tue, 08/20/2013 - 11:48
ABOUT AUTHORS:
Anjali* , Lakshmi Goswami, Dr. Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology and Sciences
Patel nagar, Dehradun
anjali23mar@gmail.com

ABSTRACT
In field of nanotechnology nonmaterial are at the leading edge. Nanotechnology has received a lot of attention with enthusiasm because of its future potential. Their unique size-dependent properties make these materials greater and indispensable in many areas of human activity. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses required. This brief review tries to summarise the most recent developments in the field of applied nanomaterials, nanoparticles, solid lipid nanoparticles, nanocrystals, nanosuspensions, nanoemulsions, in particular their application in biology and medicine, and discusses their commercialisation prospect.
5 August 2013

CHRONOPHARMACEUTICS, “FOR TREATMENT OF ARTHRITIS’’

About Authors:
Rawat Smriti*, Bisht Seema, Kothi Yal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India.
*smritirawat000@gmail.com

Abstract
Many human biological processes are regulated by circadian rhythms, which follow 24-h cycles and involve the neuroendocrine and immune systems. There is strong evidence for an impact of circadian rhythms in the symptoms of Rheumatoid arthritis, and a number of pro-inflammatory cytokines that exhibit a peculiar rhythmicity in particular serum TNF- α and serum IL-6, and together with other relevant immunological parameters display an elevation in the early morning hours. The increase in nocturnal anti-inflammatory cortisol secretion is insufficient to suppress ongoing inflammation, resulting in the morning symptoms of joint stiffness, pain, and functional disability are characterized.With chronotherapeutics becoming ever more popular, more consideration is being given to the timing of therapy for a number of chronic diseases. The recent surge of interest in the field of chronobiology has highlighted the importance of optimising timing of treatment administration. In this article we discuss the chronobiology of Rheumatoid arthritis and the availability of a new programmed-release.
WAFERS TECHNOLOGY – A NEWER APPROACH TO SMART DRUG DELIVERY SYSTEM admin Tue, 07/23/2013 - 21:29
ABOUT AUTHORS:
Papola Vibhooti *, Dr. Kothiyal Preeti
Shri Guru Ram Rai Institute of Technology & Sciences
Dehradun, Uttarakhand, India
*papola.vibhooti47@gmail.com

ABSTRACTS
The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oramucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.
A REVIEW : APPROACH IN DENTAL DRUG DELIVERY SYSTEM admin Sun, 05/12/2013 - 10:19
ABOUT AUTHORS:
Badola Ashutosh,* Nishu Sharma
Shri Guru Ram Rai Institute of Technology & Science ( SGRRITS ),
Dehradun 248001, Uttarakhand , India
*ashutosh.badolam.pharma@gmail.com

ABSTRACT:
Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing drug in a non-biodegradable polymer for targeted delivery of the drug. The polymer ethyl cellulose was used in the formulation of dental films. The dental film was then evaluated for various parameters like thickness, folding endurance, and weight variation, and content uniformity, in vitro and in vivo study. Drug release profile of the dental film showed that the film exerted an initial burst release followed by a sustained release of the drug and the drug release was well above the minimum inhibitory concentration throughout the time of study. The release data obtained were subjected for release kinetics study. The study suggested that the non-biodegradable based dental film is a potential local drug delivery device for the treatment of periodontitis.
28 January 2013

Herbal Cosmetics: A safe and effective approach

About Author:
Bhuwanchandra Joshi,
Division of Pharmaceutical Science
SHRI GURU RAM RAI INSTITUTE OF TECHNOLOGY AND SCIENCES,
PATEL NAGAR, DEHRADUN, UTTARAKHAND
*bhuwan.joshi000@gmail.com

Abstract:
The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. An herbal cosmetic have growing demand in the world market and is an invaluable gift of nature. Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Herbs and spices have been used in maintaining and enhancing human beauty. Indian women have long used herbs such as Sandalwood and Turmeric for skin care, Henna to color the hair, palms and soles; and natural oils to perfume their bodies. Not too long ago, elaborate herbal beauty treatments were carried out in the royal palaces of India to heighten sensual appeal and maintain general hygiene. The herbal cosmetics manufactured and used commonly for daily purpose include herbal face wash, herbal conditioner, herbal soap, herbal shampoo etc. The industry is now focusing on the growing segment with a vast scope of manifold expansion in coming years. Herbal cosmetics are defined as the beauty products which posses desirable physiological activity such as healing, smoothing appearance, enhancing and conditioning properties because of herbal ingredient. Here we reported the introduction, classification, common herbs used in cosmetics.

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EMERGENCE OF NOVEL PEPTIDE MOLECULAR CLASS AS ANTIBIOTICS

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