Miscellaneous Articles

ORGANOCHLORINE AND ORGANOPHOSPHOROUS PESTICIDE EXPOSURE HAZARDS IN POMEGRANATE GROWERS OF DROUGHT PRONE AREAS OF MAHARASHTRA

About Authors:
Prakash Bansode*1, Vidhin Kamble2, Raghunath Shinde1
1Department of Chemistry,
2Department of Zoology,
Sangola College, Sangola Dist.-Solapur(M.S.)
*bansode.prakash4@gmail.com

ABSTRACT
The pesticides especially organochlorines are known for their easy bioaccumulation and persistence in living systems. They are prepared on commercial scale and consumed on large amounts. In India agriculture is the backbone of economy and mean of livelihood for people living in villages. The draugthtprone areas of Maharashtra are famous for horticultural practices such as pomegranate and ber.In order to control crop pest and to improve crop yield, various synthetic agrochemicals like pesticides, fertilizers, insecticides and phytoharmones are used on large scale. Many developed countries have banned some lethal, bioaccumulative and persistence pesticides but they are still used in drought prone areas of Maharashtra and have caused   severe acute and chronic health hazards to the farmers and agricultural laborers. The present investigation was carried out to examine pesticide practices in drought prone areas and related hazards due to exposure to the organochlorine and organophosphorous pesticides.

TETRACYCLINE- FORGOTTEN ANTIBIOTICS

Presently, the name "tetracycline" refers to a number of antibiotics of either natural, or semi-synthetic origin, derived from a system of four linearly annelated six-membered rings (1,4,4a,5,5a,6,11,12a-octahydronaphthacene) with a characteristic arrangement of double bonds. The tetracycline molecule possesses five asymmetric centers: C-4, -4a, -5a, -6, and -12a.

THE HUNT FOR COUNTERFIET AND INFERIOR DRUGS

ABOUT AUTHOR
Kunal Roy
NSHM Group of Institutions Knowledge campus,
Department of Pharmaceutical Analysis & Quality Assurance
Kolkata-700053
kunal.roy17@gmail.com

ABSTRACT:
Counterfeit Culture is a one of the most important and dangerous crime in the world of drugs and its related products  and  explores the dangerous and sometimes deadly world of fake, fraudulent, and faux products. The pharmaceutical  industry has a has history of peddled knock-off  dosage forms, medical devices   but during the last 15 years, it has mushroomed into a global phenomenon.
The range of counterfeit goods now being produced includes pharmaceuticals. The traffic in counterfeit goods is now estimated at a staggering $350 billion representing nearly 10% of all global trade. This illicit and highly profitable criminal enterprise continues to grow unabated and has been linked to organized crime syndicates around the world.

MODERN METHOD OF PRESCRIBING THE DRUG WITH THE HELP OF ELECTRONIC SYSTEMS AS E-PRESCRIPTION

ABOUT AUTHORS:
Mr. Shaikh Parvej H*, Chilwant K.M., Birajdar Shivprasad M., Prof. Garad S.V.
Maharashtra College of Pharmacy,
Nilanga, dist. Latur (MS) 413521, India
*parveja2r@gmail.com

ABSTRACT
E-Prescribing is a prescriber's ability to electronically send an accurate, error-free and understandable prescription directly to a pharmacy from the point-of-care - is an important element in improving the quality of patient care. Electronic prescribing (sometimes called “eRx”),
Through e-prescribing tools, the physician has access to drug reference checking, drug-allergy interactions, and drug-drug interactions. This additional information up front ensures a safer prescription and reduces pharmacy call backs to the practice to clarify information. Also, the electronic communication is bidirectional; patients can call the pharmacy for a prescription renewal rather than the physician, and the pharmacy can then transmit an electronic message asking the physician to authorize or deny the prescription renewal.
e- Prescription has offering & cure of disease by obtaining data from the foreign expert’s clinical trials, Electronic Prescribing can save time and money. by using software skills of various software likes electronic health recordPharmacy Benefit Manager (PBM)

SOCIAL MEDIA AND IT’S INFLUENCE

We need to thanks to the new digital platforms like social media where technology is reinforcing people to create, participate, and share content on the Web, we can have meaningful conversations around events, places, people, news, brands, and products through blogs, micro-blogging sites like Twitter, Social bookmarking, and sharing sites like Digg, social networking sites such as Facebook, social forums and review sites. Virtual worlds like YouTube, Second Life, and podcasts are a few new age tools to name.

TO ASSESS THE HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH OSTEOARTHRITIS

About Author:
Nishith Sheth
M.Sc in Clinical Research
Cranfield university
sheth10687@gmail.com

Abstract
Osteoarthritis is one type of degenerative joint disease and also known as chronic musculoskeletal disease and it occurs mainly in elderly patients with the severe cause of disability. There are approximately 30 million persons affected with severe osteoarthritis and about 26 million persons are affected with severe osteoarthritis in United States only. The approximate annual cost to the public society in medical care is expected to reach 100 billion dollars by the end of 2020. From this much of cost, most of the cost is spent only in finding out the new diagnosis and treatment for this severe disease and also for the prevention of side effects. Today till 2010, 50% of the persons with the age over 75 suffer from the knee osteoarthritis. 80% of the aged persons with knee osteoarthritis feel difficulty in daily routine activities, while 20 % of the aged persons with mild osteoarthritis feel no difficulty in their daily routine activities.
In this disorder, the joint loses the slippery cartilage those results from ‘wear and tear’ on a joint. Thus the joint becomes large, thick and painful. Thus the bone near the cartilage tries to change and produce overgrowth of the bone.  That’s why the tissue near the bone becomes inflamed and ligaments lose and joint muscle becomes weak. So the people with osteoarthritis feel pain when they are doing their normal routine activities.

CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY: A COMPREHENSIVE APPROACH

ABOUT AUTHORS:
Sharma A*, Vaghela J.S, Sharma P, Sharma B, Agrawal M, Jagiwala S
Department of Quality Assurance, Bhupal Nobles’ College of Pharmacy,
Udaipur- 313002, Rajasthan, India
*life4abhishek@gmail.com

ABSTRACT
Pharmaceutical manufacturers must validate their cleaning process to ensure compliance with standard regulatory authorities. Manufacturing and cleaning equipment must be designed for effective and consistent cleaning to avoid cross-contamination and the cleaning processes must be verified as effective. An effective cleaning shall be in place to provide documented evidence that the cleaning methods employed within a facility consistently controls potential carryover of product including intermediates and impurities), cleaning agents and extraneous material into subsequent product to a level which is below predetermined levels. This article provide introduction on cleaning validation and the associated regulations, level/degree of cleaning, approaches to cleaning validation, elements of cleaning validation, acceptance criteria, validation protocols, validation reports.


Pharmaceutical product pricing policies in India: A simplified view on latest amendments

When the domestic pharmacy market is forecasted to touch US$20 billion by 2015, it was essential to do amendments in previous laws directly affecting pharmaceutical market in India. Amendment regulations are drafted by parliamentary counsel’s office for the purpose of excellence in regulation and only published in gazettes. Major change experienced by Indian pharmaceutical market recently is in pharmaceutical pricing policies.

COMPARATIVE STUDY OF DRUG PRODUCT RECALL REGULATIONS IN USA, UK AND AUSTRALIA AND DRAFT GUIDELINES FOR INDIA

About Authors: 
Bane Singh Rajput*
Research Scholar of Lachoo Memorial College of Science & Technology
Pharmacy Wing, Jodhpur (Raj.)
*bnsingh29@gmail.com

Abstract
Drug product recall is an action taken to withdraw or remove a batch or an entire production run of a drug product from distribution or use and return them to the manufacturer. It is usually done due to the discovery of deficiencies in quality, efficacy or safety in the marketed drug products. Defective drug products related to quality includes adulterated or spurious drugs. Safety and efficacy related recalls include serious adverse reactions and death. Recalls also include drugs prohibited under the law and also those products for which product licenses are suspended/ cancelled. In USA, guidelines for drug product recall are described under 21 CFR Parts 7, 107 and 1270.  In Australia, guidelines for drug product recall are described under section 65F of the Trade Practices Act 1974. Sections 2(2), 4, 5 and 7 of the European Communities Act 1972 and Directive 2001/95/EC on general product safety are followed in UK for drug product recall. In India, references for drug product recalls, complaint and adverse reactions are mentioned in Para 27, 28 of Schedule M and conditions of license for defective product recall in Rule 74(j) and Rule 78(i) of the Drugs and Cosmetics Act, 1940 and Rules there under. But no effective and uniform recall procedure and guidelines are formulated yet in India. This paper presents a comparative study of drug product recall guidelines in USA, UK and Australia. Based on this comparative study suggestions are provided to develop regulatory guidelines for drug product recall in India.

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