Madhya Pradesh

NOOTROPICS- THE MEMORY INHANCEMENT DRUGS- A REVIEW

About Author:
Rahul Singh
M.PHARMA (Pharmaceutics)
Shri Rawatpura Sarkar Institute Of Pharmacy
Kumhari, Distt-Durg , Chhatisgarh, India
rahulbaba92@yahoo.in

ABSTRACT-
This century will see the arrival of lifestyle drugs to enhance the power of our minds. These ‘smart’ drugs, or nootropics, will be substances that increase the speed of our learning and the capacity of our memory. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or by stimulating nerve growth. Nootropics has proved to be a very successful pharmacological means of raising academic performance in children with attention deficit disorder and it is therefore regarded as a nootropic. Motivation and attention are aspects of cognition that vary particularly with wakefulness. Research into learning and memory is yielding a wide range of targets for drug companies in search of the perfect nootropic.

EVALUATION OF ANTIDOTE ACTIVITY OF LEAVES OF MUSA SAPIENTUM LINN. ON RATS

About Authors:
Vishnu Dev 1*, Rajiv saxena 2
1 Truba Institute of pharmacy, Bhopal.
2 Assoc. Professor, Truba Institute of pharmacy, Bhopal
*vishnudev2007@rediffmail.com

Abstract
The present study was designed to investigate the anti-dote activity of the methanolic and aqueous extract of musa sapientum. The extract was evaluated by physical and serum biochemical parameters as TC and TG. Anti-dote activity of both extract was determined by acute and chronic codeine poisoning,
Acute opioid intoxication and overdose are common causes of presentation to emergency departments. Although naloxone, a pure opioid antagonist, has been available for many years, there is still confusion over the appropriate dose and route of administration. This article looks at the reasons for this uncertainty and undertakes a literature review from which a treatment algorithm is presented.
The anti-dote activity of musa sapientum leaves against codeine induced acute and chronic poisoning was studied in Wistar albino rats. The various fractions of the leaf extract were administered orally (200 mg/kg) simultaneously with codeine (32m g/kg) for 5-10 days. At the end of the experiment, levels of triglycerides, total cholesterol content were measured. Administration of codeine produced a CNS depressant activity and causes poisioning. There was a significant increase in total cholesterol and triglycerides when compared to normal control. physical observation indicated that simultaneous administration of the fractions delayed the onset of toxicity. All the fractions prevented the poisoning damage caused codeine overdose. The leaves of musa sapientum protected the CNS against codeine damage which may be due to its antagonist activity of codeine.

STUDY OF ANTI INFLAMMATORY ACTIVITIES OF CALOTROPIS GIGANTIA & CALOTROPIS PROCERA IN FLOWER EXTRACT

About Authors:
*1Krishna Das Gupta, 2Dileep Bharti
1M.Pharm(P'cology), NRI Institute of Pharmaceutical Sciences(NIPS), Bhopal
2Asst professor, NIPS, Bhopal(MP)
*krishna.gupta384@gmail.com

1.INTRODUCTION
Inflammation is defined as the local response of living mammalian to injury due to agent. It is a body reaction in order to eliminate or limit the spread of injurious agent as well as to remove the consequent necroses cells and tissues.
Inflammation is protective and defensive mechanism of the body. During inflammatory conditions various pathological changes are take place. The production of active inflammatory mediators is triggered by microbial products or by host proteins such as proteins of the complement, kinins and coagulation systems that are themselves are activated by microbes and damaged tissues.

The inflammatory process is closely intertwined with the process of repair. Both of these processes proceed simultaneously; however the repair activities of either tissue regeneration or scarring predominate after the injurious agent has been eliminated. The inflammatory process may be destructive to tissues when activated repeatedly or in appropriately such as in autoimmune diseases in which native antigens are recognized as foreign by the individual’s immune system.

A REVIEW ON: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET

About Authors:
Nishtha Tiwari
Department of pharmacy,
b.u Bhopal (m.p.), India
Nishthatiwari.18@gmail.com

ABSTRACT
The oral route of drug administration is the most important method for administering drugs for systemic effects. Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. The parenteral route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route.

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS

About Author:
ABHISHAK SINGH PARMAR,
M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
B.R.NAHATA COLLEGE OF PHARMACY,
MANDSAUR (M.P).
*abhishakparmar@gmail.com

1. INTRODUCTION
1.1 Medicinal and Pharmaceutical chemistry

It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1

PHARMACEUTICAL INDUSTRIES: WHAT NEXT?

About Author:
Dr. Amit Gangwal
Pharmacy college as a Lecture,
Smriti college of pharmaceutical education, Indore
gangwal.amit@gmail.com

The pharmaceutical industries world over, are in a period of crisis due to the poor number of approved drug molecules relative to the high levels of R&D investment. The drug industry is facing major scientific and strategic challenges. Conversion of genomics knowledge into new molecules seems to be unimpressive and futile. Moreover competition from generic giants is giving tough competitions to established products. Indian companies are no exception; rather, hardly any molecule has been delivered by Indian companies since time immemorial (readers are kindly requested to correct/update me, if I am not acknowledging some discovered molecule).

FORMULATION AND CHARACTERIZATION OF THEOPHYLLINE MICROSPHERE

About Authors:
Sofiya Verma*, Dipak V, Ashok A, Neha C, Jagruti R, Ashutosh. M
Shri ram institute of pharmacy
Jabalpur M.P
*sofiyavermamph@gmail.com

ABSTRACT:
The purpose of this research was to prepare and characterize theophylline microsphere of guar gum polymer for the application of nocturnal asthma. The microsphere were prepared by using emulsification method using sodium borate as a cross linking agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and   drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs and XRD spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The prepared theopylline microsphere has the potential for delaying the release of drug.

Tropical Forest Research Institute invites Junior Research Fellow, Field Assistant, Project Staff | 6 Posts

Indian Council of Forestry Research and Education (ICFRE), an apex body in the national forestry research system, has been undertaking the holistic development of forestry research through need based planning, promoting, conducting and coordinating research, education and extension covering all aspects of forestry.

A MAJOR APPROACH- 2-CHLOROPYRIDINE-5-TRIFLUOROMETHYL DERIVATIVE AS ANTIAMNESIC AGENTS

About Author:
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
ravindratomar16@gmail.com

ABSTRACT-
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-

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