Andhra Pradesh

Virchow Biotech Private Limited (VBPL), an innovative biotechnology company headquartered at Hyderabad, India. VBPL also has offices located in the United States of America ( at Nashville, Tennessee)

Wockhardt today, is distinguished by a strong and growing presence in the world's leading markets, with more than 65% of its revenue oming from Europe and the United States. Wockhardt's market presence covers formulations, biopharmaceuticals, nutrition products, vaccines and active pharmaceutical ingredients (APIs).

VJ's college of pharmacy was established in the year 2007 by pharmcy professionals at Rajahmundry in East Godavari District, Andhrapradesh. the college is offering B.Pharm, M.Pharm (Pharmaceutics, Pharmaceutical Analysis & Pharmacology)

Applications are invited from qualified individuals for Research Specialist position, sponsored by the National Institute of Animal Biotechnology (NIAB-DBT) project entitled “Studies on epigenetic regulation during lactation and its impact on milk biosynthesis” (NIAB/CP/107/2012).

Post: Senior Research Fellow

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About Authors:
YASWANTH ALLAMNENI^1*, PAVAN POTTURI¹, RAJKUMAR NULU², RAVADA RAMESH³, P DAYANANDA CHARY¹, ARUN KALEKAR¹.
¹Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh, India-509228.
²Research and Development Department, Aurobindo Pharma Ltd., Hyderabad, Andhra Pradesh, India.
³HOD, Dept. of Pharmaceutics, Dr. H.L.T. College of pharmacy, Kengal, Channapatna, Banglore(R).
*yaswanthallamneni@gmail.com

ABSTRACT
The aim of this study was to investigate the influence of superdisintegrants on the dissolution properties of a poorly water-soluble drug from complexes prepared by kneading method. Ketoprofen was employed as a model drug. Solid dispersions prepared by kneading method exhibited higher dissolution rate and DE30 values in each case. Ketoprofen tablets were prepared by direct compression technique using microcrystalline cellulose as a directly compressible vehicle. The formulated tablets were evaluated by different In Process Quality Control tests, content uniformity and in vitro drug release study. The FTIR spectra’s study revealed that there were no interaction between polymers and drug. All the tablets formulated employing solid dispersions in superdisintegrants gave rapid and higher dissolution of Ketoprofen when compared to that of Ketoprofen plain tablets. Ketoprofen dissolution from all the tablets followed first order kinetic with correlation coefficient ‘r’ above 0.9470. All dissolution parameters (k₁, DE₃₀ and T₃₀) indicated rapid and higher dissolution of Ketoprofen from tablets formulated employing its solid dispersions in superdisintegrants when compared to plain tablets.

Government of India has set up six new National Institutes of Pharmaceutical Education and Research (NIPERs) under the aegis of Ministry of Chemicals and Fertilizers, Department of Pharmaceuticals, at Rae Bareli, Hajipur, Guwahati, Kolkata, Ahmedabad and Hyderabad. These are presently being run with the help of Mentor Institutes. The Institutes are required to be established on their own.

About Author:
K. Sravan Kumar*
Department of Pharmaceutics,
Seshachala College of Pharmacy,
Puttur-517 583, 
Chittoor (dist), A.P., India
*sravank681@gmail.com

Abstract:
In this study, transdermal patches containing Nimesulide were prepared using different ratios of polyvinylpyrrolidone (PVP) and Hydroxy propyl methyl cellulose (HPMC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and HPMC was casted on a polyvinylalcohol backing membrane that was previously dried at 60⁰C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by IR spectroscopy have absence of any incompatibility. In vitro permeation studies were performed across  skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/HPMC, 5:1) and F5 (PVP/HPMC, 1:5) were chosen for further in vivo experiments. The anti inflammatory effect and a sustaining action of Nimesulide from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. Hence, it can be reasonably concluded that Nimesulide can be formulated into the transdermal matrix type patches to sustain its release characteristics.

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