Uttar Pradesh

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  • PharmaTutor
    1 August 2012

    Job as Group Product Manager, Product Specialist, Area Sales Manager & Medical Representives Synokem Pharmaceuticals

    Synokem Pharmaceuticals, founded in 1982 is an emerging pharmaceutical company with proven capabilities in the areas of manufacturing and marketing. It’s among the fast growing pharmaceutical company in India, which has grown from strength to strength and diversified its activities.
    Synokem Pharmaceuticals Ltd., a 100 crore, progressive, 28 years old organization with all India operations requires for its different

  • 29 July 2012
    FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF ATENOLOL USING SUPER DISINTEGRANT - CROSS POVIDONE AND SWEETENING AGENT - SUCRALOSE

    About Authors:
    Mizna Nigarish*, Vandana Arora Sethi
    Lloyd Institute of Management and Technology
    Plot no.2 knowledge park-2,
    Greater Noida-201306 (U.P)
    *mnigarish2@gmail.com

    ABSTRACT
    The present study has been undertaken to prepare fast dissolving tablets of atenolol by direct compression method with a view to enhance patient compliance. The superdisintegrant used in this study was crosspovidone and sucralose as a sweetening agent. A new formulation of atenolol tablet was designed and compressed by direct compressionmethod. Then its physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test were performed for evaluation and characterization of this new formulation. It was observed in the result that the tablet formulation F-4 was found to have maximum drug release at the end of 6 minutes and considered as the most effective formulation. It was also concluded that direct compression technique is a useful method for preparing fast dissolving tablets.

  • 29 July 2012
    Government career for Pharmacist, Engineer & other in North Eastern Railway - Total 65 posts

    North Eastern Railway has issued notification against recruitment of 65 various vacancies under Special Recruitment Drive against Physically Handicapped Quota. Eligible candidates may apply through prescribed application format on or before 06-08-2012. Other details like age limit, educational qualification, application fee details, selection process and how to apply are given below

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  • 27 July 2012
    TASTE MASKING OF BITTER DRUGS USING DIFFERENT TECHNIQUES FOR BETTER PATIENT COMPLIANCE: AN OVERVIEW

    About Authors:
    MIZNA NIGARISH*, VANDANA ARORA, SAVITA BHATI
    LLYOD INSTITUTE OF MANAGEMENT AND TECHNOLOGY
    PLOT NO.2 KNOWLEDGE PARK-2
    GREATER NOIDA-201306
    (U.P)
    *mnigarish2@gmail.com

    ABSTRACT:
    Taste is an important parameter in administering drugs orally, unwanted or bitter taste is one of the most important formulation problems that are encountered with many drugs and it becomes very necessary for bitter drugs to improve the patient compliance especially in the pediatric and geriatric patients. To overcome with this problem certain taste masking techniques are used in this article, the main aim is to combat with the bitterness using various technologies so as to obtain the desired drug.

  • 25 July 2012
    Application for the Post of Manager - Marketing in PharmaSecure PAS India Pvt. Ltd.

    PharmaSecure is a software and technology company based in the US and India with partners located around the world. A leader in pharmaceutical serialisation, authentication, and e-health, PharmaSecure protects trusted products and enhances consumer access to health information and services.

  • 18 July 2012
    Work as Director in National Institute of Nutrition and NJIL&OMD

    National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu.

  • 16 July 2012
    SELECTIVE ESTROGEN RECEPTOR MODULATORS: ANTIBREAST CANCER AGENTS

    About Authors:
    Rawat Pinki1*, Rawat Preeti2, Kumar Piyush3 Kanoujia Jovita3, Singh Sangeeta 1
    1. Institute of Pharmaceutical Science and Research, Unnao, U.P., India.
    2.  L.T.R. College Of Technology, Meerut, U.P., India.
    3. Curadev Pharmaceuticals Ltd., Kanpur, U.P., India.
    *pnkrawat@gmail.com

    Abstract:
    Selective estrogen receptor modulators, called SERMs for short, blocks the naturally circulating estrogen in breast tissues and other estrogen-sensitive tissues in the body. Each estrogen receptor has a slightly different structure, depending on the kind of cell it is in. If a SERM binds to a estrogen receptor, there is no site available for estrogen to bind and it can't attach to the cell. SERMs are called "selective" because they bind to particular estrogen receptors. This selective binding action is sometimes called estrogen inhibition, or estrogen suppression.

  • 12 July 2012
    REVIEW ARTICLE: Solid Dispersions

    ABOUT AUTHORS:
    D.PRAVEEN KUMAR*, Vandana Arora
     M.Pharm (Pharmaceutics)
    Lloyd Institute of Management & Technology,
    Greater Noida,
    U.P., India
    * praveen_73a@yahoo.co.in

    ABSTRACT
    The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Currently only 8% of the new drug molecules have high solubility and permeability. The solubility behaviour of a drug is key determinant to its oral bioavailability and it is the rate limiting step to absorption of drugs from the gastrointestinal tract. This results in important products not reaching the market or not achieving their full potential. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion, types of solid dispersions based on molecular arrangement and other aspects such as selection of carriers and methods of characterization and their applications have been discussed.

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  • 11 July 2012
    Opportunity for freshers to work in Olefia Biopharma as Marketing Executives - 13 posts

    Olefia Biopharma Limited, We would like to introduce ourselves as one of the most rapidly emerging FMCG Company in various fields of Pharmaceutical, Cosmetics, Ayurvedics / herbals and biotech.

  • 6 July 2012
    PRONIOSOMAL POWDERED DRUG DELIVERY SYSTEM OF FLURBIPROFEN :FORMULATION AND EVALUATION

    About Authors:
    *Sunil kumar, Amit kumar shahi, Ravi shanker, R. singh, Dr. R. ParthSarthy, Dr S.K. Prajapati
    Kamla Nehru institute of technology and management, Sultanpur.
    Bundelkhand university, Department of pharmacy, Jhansi
    *sunil.sunilpharma.kumar@gmail.com

    ABSTRACT
    The purpose of this research is to design proniosomal powder drug delivery system of flurbiprofen in a trial to overcome the adverse effects associated with oral administration of the drug. Conventional chemotherapy for the treatment of intracellular infection is no more effective due to limited permeation of drug into cell. This can be overcome by the use of vesicular drug delivery system. Encapsulation of a drug in vesicular structure can be predicted to prolong the existence of the drug in the systemic circulation and thus enhance penetration into target tissue and reduce toxicity.Proniosomal powder are generally present in transparent, translucent or white texture, which makes them physically stable during storage and transport. Due to the limited solvent system present, the proniosomes formed were the mixture of many phases of liquid crystal, viz. lamellar, hexagonal and cubic phase liquid crystals.The potential of proniosomes as a transdermal drug delivery system for flurbiprofenwas investigated by encapsulating the drug in various formulations of proniosomal powder composed of various ratios of sorbitan fatty acid esters, cholesterol, prepared by slurry method. The formulated systems were characterized in vitro for size, vesicle count, drug entrapment, drug release profiles and vesicular stability at different storage conditions. Stability studies for proniosomal powder were carried out for 4 weeks. The method of proniosome loading resulted in an encapsulation yield of 30.6 – 75.4%. Proniosomes were characterised by transmission electron microscopy. In vitro studies showed prolonged release of entrapped flurbiprofen. At refrigerated conditions, higher drug retention was observed. It is evident from this study that proniosomes are a promising prolonged delivery system for captopril and have reasonably good stability characteristics.

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