Uttar Pradesh

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  • PharmaTutor
    6 January 2013

    SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES

    About Authors:
    Aditya Dixit1, Gyanendra Kumar Sharma2, Devender Pathak*3
    1M. Pharmacy (Pharmaceutical Chemistry)
    2Associate Professor (Pharmaceutical chemistry)
    3Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
    Rajiv Academy for Pharmacy, Mathura,
    Delhi-Mathura Highway, Chhattikara, 281006, India
    dev_15@rediffmail.com*, adixit70@gmail.com

    ABSTRACT
    A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, 1H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.

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  • 4 January 2013
    Opening for M.Pharm as Project Associate in Indian Institute of Technology Kanpur

  • 1 January 2013
    DENDRIMERS FOR NOVEL DRUG DELIVERY: AN OVERVIEW

    About Authors:
    Roopesh Sachan    *1, Prof. Satyanand Tyagi2, Tarun Parashar1, Soniya1, Patel Chirag J*3,Patel Pinkesh3, Rishikesh Gupta4
    1    *Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
    2    President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
    3    Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
    4    Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
    *roopeshsachan@gmail.com, +91-9557469989, 9236167104

    ABSTRACT:
    Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimer such as Polyester dendrimer, Citric acid dendrimer, Arginine dendrimer, Glycodendrimers, PEGylated dendrimers, etc.The field of Dendrimers has recently emerged as the most commercially viable technology of this century because of its wide-ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, engineering products, pharmaceuticals, drug delivery, catalysis, electronic devices, environmental issues and nanotechnologies. Dendrimer as a drug delivery agent is a promising, safe and selective drug delivery option.

  • 31 December 2012
    Application are invited form Lecturer ( Pharmacy) in Public Service Commission, Uttar Pradesh | Government Job

    Applications will be accepted only when fee is deposited in the Bank upto prescribed last date for fee submission. If the fee is deposited in bank after prescribed last date for fee submission, the candidature of the candidatewill be rejected and application will not be accepted. Once fee deposited in the bank will not be refunded to the candidate in any condition.

  • 28 December 2012
    Workshop on Applications of Mass & NMR Techniques in Central Drug Research Institute

    CSIR-Central Drug Research Institute, Lucknow is a premier R&D Institute under the aegis of the Council of Scientific and Industrial Research (CSIR), New Delhi which is an autonomous body under Department of Scientific and Industrial Research, Government of India.

  • 28 December 2012
    Advertisement for Program Coordinator, Project Assistant in Central Drug Research Institute

    In order to harness the bioactive principles from the vast marine biota occurring in Indian waters for human therapeutic purposes, Ministry of Earth Sciences, Government of India, has been implementing a multidisciplinary and multi-institutional Research and Development programme on “Development of potential drugs from ocean (Short title : Drugs from the Sea)”

  • 23 December 2012
    Multiple vacancies for B.Pharm, M.Pharm at Shri Ram Murti Smarak College of Engineering & Technology

    Shri Ram Murti Smarak College of Engineering & Technology, Bareilly & Lucknow are the self financed institutes managed and run by SRMS Trust. It is founded in 1996 and the college has demonstrated perennial evidence of merit and quality by achieving a respectable position among all parallel private and govt. colleges of UP Technical University.

  • 23 December 2012
    Walk in interview for M.Pharm, M.Sc in CDRI | 9 Posts

    CSIR-Central Drug Research Institute, Lucknow is a premier R&D Institute under the aegis of the Council of Scientific and Industrial Research (CSIR), New Delhi which is an autonomous body under Department of Scientific and Industrial Research, Government of India.

  • 21 December 2012
    ANTIANXIETY ACTIVITY OF EMBELIN ISOLATED FROM EMBELIA RIBES

    About Authors:
    Mukesh Bansal1*, Indrajeet Singhvi2, Santosh Gupta2
    1Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, U.P., India.
    2Pacific College of Pharmacy, Pacific University, Udaipur, Rajasthan, India.
    *bansalpharma1987@gmail.com

    Abstract:
    Object:
    To investigate the effect of embelin  on anxiety   was studied  by using standard test such as Elevated zero-maze test and Novelty induced suppressed feeding latency test in a dose dependent manner.
    Material & methods:
    This portion include extraction and isolation of embelin, animals were obtained from the animal house IMS, BHU, Varanasi, India, and methods for anxiety were Elevated zero-maze test and Novelty induced suppressed feeding latency test.
    Result & conclusion:
    The  anxiolytic  activity was found at 20mg/kg. The observed anxiolytic effect of this compound seems to be regulated through monoaminergic system in the brain and the activity was comparable to diazepam.

  • 19 December 2012
    Work as Professor, Associate Professor, Assistant Professor in Noida Institute of Engg.&Tech | Walk in

    The Department of Pharmaceutical Technology of Noida Institute of Engineering and Technology was established in 2005. Pharmacy education in India has advanced to the global standards. Recent GATT agreement and patent rules have given a thrust to the research and development activities leading to search for newer and active drug molecules.

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