The Babasaheb Bhimrao Ambedkar University

Babasaheb Bhimrao Ambedkar University was established in Lucknow in 1996 as Central University (By an Act of Parliament 1994) with the objects of promoting advance knowledge by instructional and research facilities in science, key and frontier areas of technology and other allied disciplines. This University is the Post-Graduate and research niversity & main objective of this University is to promote professional studies, Inter-disciplinary studies, research and development activities.

With reference to Advertisement no. 02/BBAU/2016 dated 24.06.2016, exceptionally qualified candidates are invited to attend Walk-in-Interview for Assistant Professor (on contract) for BBAU, Lucknow and Assistant Professor (on contract) / Guest Faculty for Satellite Campus of BBAU at Amethi for the following courses / subjects as per date and time mentioned below:

Post: Guest Faculty

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ABOUT AUTHORS:
Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
*raj.vinit24@gmail.com

ABSTRACT
Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca⁺⁺ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca⁺⁺ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca⁺⁺ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of  novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand  produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.

The Babasaheb Bhimrao Ambedkar University, Lucknow is one of  the youngest central universities in the country. The jurisdiction of this residential University is over the entire state of Uttar Pradesh. The campus Vidya Vihar is located off Rae Bareli Road, about 10 kms south of the Charbagh Railway Station, Lucknow. The objects of the University IS to promote advanced knowledge by providing instructional and research facilities in such branches of learning as it may deem fit.

Online applications are invited from exceptionally qualified candidates for the following Teaching positions of the University in the following Schools/Departments/Centre. The University currently offering Graduate/Post Graduate and Doctoral programmes.

Post: Associate Professor – 2 (SC-1, ST-1), Assistant Professor -1 (UR)

The Babasaheb Bhimrao Ambedkar University, Lucknow is one of  the youngest central universities in the country. The jurisdiction of this residential University is over the entire state of Uttar Pradesh. The campus Vidya Vihar is located off Rae Bareli Road, about 10 kms south of  the Charbagh Railway Station, Lucknow.

The Babasaheb Bhimrao Ambedkar University, Lucknow is one of  the youngest central universities in the country. The jurisdiction of this residential University is over the entire state of Uttar Pradesh. The campus Vidya Vihar is located off Rae Bareli Road, about 10 kms south of  the Charbagh Railway Station, Lucknow. The objects of the University IS to promote advanced knowledge by providing instructional and research facilities in such branches of learning as it may deem fit