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  • FLOATING DRUG DELIVERY SYSTEM AS AN APPROACH TO INCREASE THE GASTRIC RETENTION OF DRUGS

    About Authors:
    Arpit Sharma
    School of Pharmaceutical Sciences, Shoolini University
    Solan, H.P. India

    asarpitsharma1@gmail.com

    Abstract
    The gastro retentive drug delivery system is a novel approach for the drugs having narrow absorption window in the gastrointestinal tract and has poor absorption. Gastro retentive drug delivery system mainly prolongs the gastric emptying time, thereby targeting site-specific drug release. Several techniques such as floating drug delivery system, low density system, raft system, mucoadhesive system, high density system, super porous hydro gel and magnetic system, have been employed. The physiological problems like short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms which provide opportunity for both local and systemic effect. Floating drug delivery system enable prolonged and continuous input of the drug to the upper part of the gastro retentional tract and improve the bioavailability of medication that is characterized by a narrow absorption window. The present review addresses briefly about the floating drug delivery system.

  • Pharmaceutical Process Validation: A CGMP Concept

    About Authors:
    Satinder Kumar
    Manav Bharti University,
    Solan (H.P)

    skcrock87@yahoo.in

    Abstract:-
    Validation is the most recognized and important parameter of GMPs. This article provide introduction about the process validation of pharmaceutical manufacturing process and its importance according to The U.S. Food and Drug Administration (FDA). This work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process. Quality cannot be ensured by sampling, testing, release of materials and products. Quality assurance techniques must be used to build the quality into the product at every step and not just tested for at the end. Process validation of a process will ensure production of drug of reproducible quality. In pharmaceutical industry, Process Validation performs this task to build the quality into the product because according to ISO 9000:2000, it had proven to be an important tool for quality management of pharmaceuticals.

  • Stevia rebaudiana : a ray of life for diabetics

    Stevia rebaudianais a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. Leaves of this plant produce zero calorie, high potency sweetener and substitute to sucrose, being about 300 times sweeter than sucrose. The compounds, named stevioside and rebaudiocide give stevia its taste. In India number of diabetic people in the age group of 25-45 is about 15% and is also increasing at an alarming pace. In addition, India is the largest consumer of sugar in the world. So stevia is attaining attention in Indian market as a healthy alternative sweetener to sugar. Stevia has no calcium cyclamate, no saccharim, no aspartame and no calories. It is safe for diabetics, as it does not affect blood sugar levels and have no neurological or renal side effects.

  • Stomach Specific Mucoadhesive-A Review

    About Authors:
    Shalini Sharma, Manoj Prashar
    Manav Bharti University,
    Solan

    ABSTRACT
    Stomach specific mucoadhesive drug delivery system(MADDS) is one of the most prominent and latest system which sustain drug blood concentration and controlling the rate of drug delivery to the target tissue. These systems interact with mucin molecule and mucous layer covering the mucosal epithelial surface and prolong the residence time of the dosage form at the site of application or absorption and thus contribute to improve or better therapeutic performance of drug. This review article also present the polymer used for preparation of mucoadhesive tablet, mechanism of mucoadhesion, factor affecting mucoadhesion and recent developments or techniques in formulation of mucoadhesive tablet and invitro and invivo evaluation of mucoadhesive tablets.

  • Career in Colgate as a Team Leader - Analytical

    The Training and Development effort at Colgate-Palmolive is a direct outcome of the Individual Development Plan and the Business need. The business critical and individual specific needs are identified every year and a training needs inventory is drawn up.

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