Gujarat

Medical and Health Services, Dadra and Nagar Haveli invites applications for the following post on regular basis.

Post: Pharmacist Group C

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ONGC, a ‘Maha Ratna’ Public Sector Enterprise, and India’s flagship energy company is engaged in Exploration and Production of Oil and Gas in India and abroad. A Global Energy majors, it contributes to 80% of India’s Domestic Oil Production. ONGC’s annual net profit is excess of Rs. 25,123 Crores currently. ONGC, through its subsidiary ONGC Videsh Ltd.(OVL), is India’s biggest Transnational Corporate with overseas investment of over 10 Billion USD in 16 Countries.

The Gujarat Technological University was established vide Gujarat Act No. 20 of 2007. The main objective of the University is to develop the knowledge of science, engineering, technology, management and environment for the advancement of quality of life of the mankind in general. The prime objects of the University shall be to create centres and institutes of excellence is basic and applied science, engineering and technology.

Applications are invited for the position of Junior Research Fellow (JRF) in DBT sponsored project "Unravelling the cross talk between inflammation and apoptosis: Focusing on regulation of inflammatory mediators and apoptosis in cancer".

Post: Junior Research Fellow

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About Authors:
Kalpesh Ashara
Registered Pharmacist S.K.R.I.Medicines Centre, Rajkot, Gujarat, India,
M.Pharm Semester-I Student of B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics GTU, Gujarat, India.
kalpeshashara@yahoo.com, kalpeshshr5@gmail.com*

Abstract:
Spectrophotometry is an attractive method for PKa determination in very diluted aqueous solution about 10^-5 to 10^-6M provided that the compound possesses P^H dependent light absorption due to the presence of a chromospheres in proximity to the ionization centers. Traditionally 6 to 8 aliquot solutions of samples in identical concentrations but with different P^H values are prepared & their absorption spectra are registered at single wavelength. This series of solutions can be generated by either preparing the sample in buffer solutions of known P^H or titrating the sample solution e.g. alkalimetry. Then half the absorbance of maximum plotted on graph & interpolated on x-axis that will give value of P^H is Pka  & negative Antilog of that value at base 10 give value of ka i.e. Dissociation Constant (Pka=-logka). This exercise is carrying out in below assignment.

Asian Aerosol OAN Pvt. Ltd. promoted in collabration with Japanese based Daizo company; Australian based Pax company, is looking for potential team members lor new aerosol facility construction for personal care toiletries/ household/ FMCG/ Pharma manufacturing.

About Authors:
Dhirendra C. Patel^1*, Ritesh B. Patel¹, Gargi B. Patel^2
1Department of Pharmaceutics and Pharmaceutical Technology;
S.K. Patel College of Pharmaceutical Education and Research;
Ganpat University, Kherva, Mehsana, Gujarat, India.
²Pharma Management & Regulatory Affairs,
K.B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.
*dhiren.pharmacy@gmail.com

Abstract:
Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the obvious advantages of oral route of drug administration. However, there are certain conditions for which such a release pattern is not suitable like cardiovascular diseases, Diabetes mellitus, Asthma, Arthritis, Peptic ulcer etc. In such cases pulsatile drug delivery system is used in which release drug on programmed pattern i.e. at appropriate time & at appropriate site of action. Pulsatile Drug Delivery systems are basically time controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility, etc. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. In chronopharmacotherapy drug administration is synchronized with biological rhythms to produce maximal therapeutic effect & minimum harm for the patient. Technically, pulsatile drug delivery systems administered via the oral route could be divided into two distinct types, the time controlled delivery systems and the site-specific delivery systems, thus providing special and temporal delivery. In recent pharmaceutical applications involving pulsatile delivery; multiparticulate dosage forms (e.g. pellets) are gaining much favor over single-unit dosage forms. Various pulsatile technologies have been developed on the basis of methodologies, these includes ACCU-BREAK™, AQUALON,  CODAS®, PRODAS^®, SODAS®, MINITABS^®, DIFFUCAPS®, OROS® etc. Designing of proper pulsatile drug delivery will enhance the patient compliance, optimum drug delivery to the target side & minimizing the undesired effects.

About Authors:
*Kalpesh Ashara, Jignesh Solanki
B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics,GTU, Gujarat, India.
*kalpeshshr5@gmail.com

Abstract:
Microspheres are solid spherical particles containing a dispersed drug in organic solution fall in a range of 1-1000mm. Microspheres or micro particles are monolithinic device refer to a rate controlling matrix throughout the drug is dissolved or dispersed, while microcapsules are device which consists of cell-like dosage forms with the drug contain within the rate controlling membrane. Microspheres are prepared by several methods. Here Microspheres are prepared using a surface active agent SLS. Then Evaluation of Microspheres is carried out by means of several parameters. Then concluded that the diclofenac: polymer ratio of 1:2 & organic solvent (MeOH: DCM) ratio of 1:4 was found to be optimum for spherical shape of microspheres as well as Practical Yield.

Applications are invited for the position of SRF in ICMR sponsored project: "The study of mitochondrial dynamics during S aureus infection in human epithelial cells" with Dr. Rajesh Singh, Assistant Professor, Cell Biology Group, IIAR.

Post: SRF (One post)