Mehsana

Walk in interview for B.Pharm, M.Pharm, M.Sc in Operations, Quality Control, Support at Torrent Pharma

Torrent Pharma, the flagship Company of Torrent Group, with a turnover of Rs. 7673 Cr is one of the leading Pharma companies in the Country. We are the pioneers in initiating the concept of niche marketing in India and today is ranked amongst the leaders in therapeutic segment of cardiovascular (CV), central nervous system (CNS), gastro-intestinal (GI) and women healthcare (WHC). The Company also has significant presence in diabetology, pain management, gynaecology, oncology and anti-infective segments.

REVIEW ON GOOD DOCUMENTATION PRACTICE IN PHARMACEUTICAL MANUFACTURING UNIT AS PER EUROPEAN UNION GMP CHAPTER-4 ON DOCUMENTATION

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ABOUT AUTHORS
Suleman S. khoja * 1, Dr. L J. Patel 2, Sohil S. Khoja 3, Karim R. Panjwani 3, Jagdish Ray3
1 PhD. Research Scholar, Ganpat University, Mehesana, Gujarat, India
2 Faculty of Pharmacy, Ganpat University, Mehesana, Gujarat, India
3 Resource person, Pharmaceutical Quality Assurance, Audit and Compliance, Vapi, Gujarat, India

ABSTRACT
Good documentation constitutes an essential part of the quality assurance system and is key to operating in compliance with GMP requirements. Documentation requirements of maintaining complete, accurate, truthful and verifiable data in all cGXP documents that are needed to be maintained as per regulatory requirements and various Governmental regulations, laws, rules and statutes/acts. Documentation may exist in a variety of forms, including paper-based, electronic or photographic media. Ensure that the Document should be free from error and during any point if error identify then rectify with proper reason for correcting including sign and date. A system should be in place to indicate special observations and any changes to critical data. GMP Document must have predefined retention period and document must be stored in secure and easy to retrieve or easily available as and when required. Batch Processing and Packaging Instruction must be in place and Contemporaneous entry provision must be available. Instruction and procedure for using equipment; instrument must be clear and specific.  Specification with authorization should be available for analysis of Raw Material and Packing Material, Intermediate and Bulk Product, Finished Product.

Walk in interview for M.Pharm, B.Pharm in Multiple Departments at Torrent Pharma

Torrent Pharma, the flagship company of Torrent Group, is ranked amongst the top pharma companies of India It is a dominant player m the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro intestinal, diabetology.  anti infective and pain management segments Torrent Pharma has a strong international presence spanning over 70 countries across five continents with over 1200 product registrations. Today. Torrent Pharma, with its state of the art manufacturing and research facilities and a global presence, is all poised to carve a ruche for itself *1 the international pharma arena.

Walk in interview in Quality Control at Torrent Pharma | M.Pharm, B.Pharm, M.Sc

Torrent Pharma, the flagship company of Torrent Group, is ranked amongst the top pharma companies of India. It is a dominant player in the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro-intestina, diabetology, anti-infective and pain management segments. Torrent Pharma has a strong international presence spanning over 70 countries with over 1200 product registrations.

Post : Trainee / Technical Assistant / Executive

Ganpat University invites Applications for post of Assistant Professor in SKPCPER

Ganpat University as a well reputed State Private University established in 2005 through the State Legislative act no 19 of 2005, Government of Gujarat and recognized by the UGC under the section 2(f) of the UGC Act, 1956 having campus spread over more than 300 acres of land with world class infrastructure and more than 10,000 students on campus. The University offers Diplomas, Under Graduate, Post – Graduate and Research Programs under the Faculties of Engineering and Technology, Pharmacy, Management, Computer Applications, Sciences, Education.

Ganpat University invites eligible candidates for the post of Assistant Professor as undermentioned

Boehringer Ingelheim Requires Area Sales Manager

Boehringer Ingelheim is an equal opportunity employer who takes pride in maintaining a diverse and inclusive culture. We embrace all aspects of diversity and inclusion which benefit our employees, patients and communities. Minority/Female/Protected Veteran/Person with a Disability (Applicable in United States of America).

Post : Area Sales Manager - Mehsana (Diabetes)-176365

STUDY OF IN-VITRO BIOTRANSFORMATION OF PRODRUGS OF ESTER AND AMIDE LINKAGES OF IBUPROFEN, DICLOFENAC SODIUM AND PARACETAMOL IN ACIDIC AND ALKALINE MEDIUM

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ABOUT AUTHOR
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT: Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible for hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting release into free parent drug by biotransformation. The HPLC (High Performance Liquid Chromatography) study reports the retention time (Rt) and release kinetics of three Prodrugs by taking HPLC degradation datas of three samples of Prodrugs and individual HPLC datas of parent drugs separately to compare the Rt value of release of three drugs from Prodrugs in both acidic and alkaline pH. Prodrug–A (logP=4.56) releases Ibuprofen & Paracetamol, Prodrug–B (logP=4.90) releases Diclofenac & Paracetamol and Prodrug–C (logP=6.13) releases Ibuprofen & Diclofenac. This is a comparison study of drug release in in-vitro gastric as well as intestinal pH focusing on in-vivo biotransformation.  Keywords: Prodrug-A/Prodrug-B/Prodrug-C, Ibuprofen, Paracetamol, Diclofenac sodium, Molecular weight, logP, UV λmax, IR, Mobile phase, TLC-Rf value, HPLC-Rt value, LOD, LOC

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