• 24 March 2013

    DESIGN, DEVELOPMENT AND FUTURE APPLICATION OF MICROSPHERES

    About Authors:
    Divya Rawat, U.K.Singh, Faizi Muzaffar
    Kharvel Subharti College of Pharmacy,
    swami Vivekanand subharti university, Subhartipuram,
    N.H-58, Meerut By Pass Road, Meerut, Uttar Pardesh-250001, India
    *drawat05@gmail.com

    Abstract
    Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres, different methods to preparation, its applications and also various parameters to evaluate their efficiency.

  • 22 March 2013
    ORAL DELIVERY OF INSULIN AND ITS CURRENT STATUS

    About Authors:
    Kritika Rastogi, U.K. Singh, A.K. Chaturvedi
    Kharvel Subharti College of Pharmacy, (swami vivekanand subharti university) subhartipuram,
    N.H-58, Meerut By Pass Road, Meerut, Uttar pradesh-250001,India.
    *kritikarastogi6@gmail.com

    Abstract
    Insulin remains the most effective and durable hypoglycemic agent for the treatment of diabetes. Insulin is a major protein hormone secreted by beta –cells of the pancreas and is important for the control of diabetes. Insulin has an important place in drug therapies for insulin dependent diabetes mellitus (type I) and for many patients with non-insulin-dependent diabetes mellitus (type II). It would be highly advantageous if insulin could be administered orally, because the oral delivery of insulin can mimic the physiological fate of insulin and may provide better glucose homeostasis. The desire to deliver protein and peptide biopharmaceuticals conveniently and effectively has led to the intense investigation of targeted delivery systems. The goal of oral insulin delivery devices is to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.

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  • 16 January 2013
    Walk in interview for the Post of Trainee Medical Representative in Systopic Labs

    Systopic is an established pharmaceutical organization with an enterprising field force of 750, we believe in Nurturing Talent & help our people grow. A befitting remuneration package along with one of the best incentive schemes ensures that performers are appropriately rewarded.

  • 7 January 2013
    NASAL DRUG DELIVERY SYSTEM: A COMPLETE REVIEW

    About Authors:
    Dharmendra Kumar*1, Sumedha Bansal1
    1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
    Meerut, Uttar Pardesh, India, 250005
    *rvnimiet@gmail.com

    Abstract:
    In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to administration, bypass first pass metabolism, excellent penetration, low dose required, rapid absorption and gives desirable effects. So many times nasal drug delivery has been considered as alternative of parenteral route. The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in various disease. So we have expectation, that researches and others cited person get benefitted from this review.

  • 6 December 2012
    BIT Group of Institutions invites Directors, Professors, Associate Professors, Assistant Professors for Pharmacy

    BIT was established in the year 2001 to spread knowledge in the fields of Engineering &Technology, Pharmacy and management Education by a group of illustrious entrepreneurs under the name Space Age Research and Technology Foundation Charitable Trust. BIT Group of Institutions having four Schools stands amongst the renowned Management and Technical Education Centre imparting courses catering to the needs of industry and providing contribution in the field of consultancy and research.

  • 26 November 2012
    ROLE OF CHROMATOGRAPHY IN EVALUATION OF HERBAL DRUGS: A SHORT REVIEW

    About Author:
    Alimuddin Saifi
    N.K.B.R. College of Pharmacy & Research Centre,
    Meerut
    asaifi2005@gmail.com

    Abstract
    Herbal drugs are accepted as important therapeutic agents for the treatment of many diseases. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Pharmacognostical analysis of medicinal herbs remain challenging issues for analytical chemists, as herbs are a complicated system of mixtures. Analytical separation techniques for example high performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry (MS), High Performance Thin Layer Chromatography (HPTLC) etc. among the most popular methods of choice used for quality control of raw material and finished herbal product.

  • 16 October 2012
    NOVEL FAST DISSOLVING TABLETS: A COMPREHENSIVE REVIEW

    About Authors:
    Tyagi Nitin*, Singh Vikram Jeet, Mishra Santosh Kumar
    CARPS, Faculty of Pharmaceutical Sciences, Shobhit University,
    Meerut, U.P.(250110), India.
    *nitintyagi27@yahoo.in

    Abstract
    These tablets were introduced in 1980s in the market  and since their introduction in the market the fast dissolving tablets are gaining popularity regularly. Due to their rapid disintegration or dissolution in the oral cavity as they come into contact of saliva normally with in one minute, without the use of water these provides patient compliance particularly to the pediatric, geriatric ,bedridden patients and for patients who are very much busy in travelling and does not have easy access to water. The present article aims on the recent advancements in the fast dissolving tablets and provides a good information about the advantages,limitations, mechanism of action of superdisintegrants, the conventional and patented development techniques and about the evaluation parameters of the fast dissolving tablets.

  • 14 September 2012
    ALTERING STATE OF AFFAIRS OF PACKAGING IN PHARMACEUTICAL INDUSTRY: A REVIEW

    About Authors:
    Nishant kumar gupta, *Aadesh kumar
    Dept. of pharmacy BIT meerut
    *adesh.adi.chaudhary@gmail.com

    Abstract:
    There was a point in time when packaging in pharmaceutical industry is symbolized for substantial safeguard, for identification and for merely endowing with a piece of information to any person who agree to it. But the changing scenario has been conveyed an assortment of changes, as in this day and age packaging provides the prevention of product tampering and counterfeiting, the assurance of product dispensing accuracy, child protection and the promotion of patient compliance with product dosage schedules. In the precedent time we used packaging materials, labels, holograms and some introductory communications; but these days together with them we use mobile applications, an innovative and creative unit, altering labeling standards, luxurious packaging, a packaging development team, anti-counterfeiting packaging extravaganza, hi-tech module for packaging demonstrate and an intelligent outlook. Packaging schoolwork has such an individual place in the market of counterfeit or fake drugs as nowhere. Packaging developer has an only effort to engender a special design that can competent with both fake brands and generic brand of that drug with ‘Me-too’ names.

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  • 13 September 2012
    PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF DICLOFENAC SODIUM

    About Authors:
    Renu1*, Shashi Kant2*, Rajendra Yadav3, Amit Kumar Tyagi4
    1Faculty of Pharmacy, Shivdan Singh Institute of Technology and Management, Aligarh (U.P)
    2Jubilant Chemsys Ltd, Noida,
    3Department of Pharmaceutical Sciences, Gurukul Kangri University Haridwar, 
    4Department of Chemistry, Meerut College, Meerut (U.P)
    *shashi.pharma83@gmail.com

    ABSTRACT :
    Diclofenac is currently the eighth largest-selling drug and the most frequently used NSAID (Non-steroidal anti-inflammatory drug) in the world, since its introduction in Japan in 1974. Diclofenac is among the better tolerated NSAIDs. Only major adverse effect of Diclofenac is that it causes direct and indirect irritation of the gastrointestinal tract (GIT). To reduce the side effects on gastrointestinal tract (GIT) and to improve therapeutic efficacy of Diclofenac, it can be formulated in polymeric microspheres.
    The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled release. Diclofenac sodium (DS), is a potent drug in the NSAID group having non-steroidal, anti-inflammatory properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. In this present study, it was aimed to prepare microsphere formulations of DS using a natural biodegradable polymer as a carrier for administration to extend the duration period of the dosage form. Microsphere formulations of DS which were prepared were evaluated in vitro for particle size, yield value, encapsulation efficiency, surface morphology, and in vitro drug release.

  • 21 August 2012
    RECENT ADVANCEMENTS: MICROSPONGE DRUG DELIVERY SYSTEM; A REVIEW

    About Authors:
    Deepak Sharma*, Arunabha Banik, S k Gupta
    Department of Pharmaceutical Technology,
    MIET,Meerut
    *thakraan.southcarolina@gmail.com

    ABSTRACT
    The Microspongesdelivery system are extremely small, inert,indestructibleclusters of even tinierspherical particles of microscopic sizepatented polymeric delivery systems consisting of porous microspheres that can entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens, and anti-infective, anti-fungal, and anti-inflammatory agents and are very well tolerated, and highly efficacious, novel productsthat do not pass through the skin, capable of holding four times their weight in skin secretionsand can absorb skin secretions. Like a true sponge, each microspheres consists of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface. The size of the microsponges can be varied usually from 5-300µm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. Although the microsponge size may vary, a typical 25µm sphere can have up to 250000 pores and an internal pore structure equivalent to 10ft in length providing a total pore volume of about 1ml/g. This results in a large reservoir within each microsponge, which can be loaded with up to its own weight in active agent. The microsponge particles themselves are too large to be absorbed into the skin and this adds a measure of safety to these microsponge materials. Another safety concern is the potential bacterial contamination of the materials entrapped in the microsponge. Because the size of the pore diameter is smaller than bacteria, ranging from 0.007 to 0.2µm, bacteria cannot penetrate into the tunnel structure of the microsponges.The microsponge system can prevent excessive accumulation of ingredients within the epidermis and the dermis. Potentially, the microsponge system can reduce significantly the irritation of effective drugs without reducing their efficacy.

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